Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus

Veterinary Immunology and Immunopathology

Volumn 142, Issue 3-4, 2011, Pages 170-178

  Wang, Gang ^a,b   Song, Tengfei ^a,b   Yu, Ying ^a   Liu, Yonggang ^b   Shi, Wenda ^b   Wang, Shujie ^b   Rong, Fulong ^b   Dong, Jianguo ^b   Liu, He ^b   Cai, Xuehui ^b   Zhou, En Min ^a,c  

^a SHANDONG AGRICULTURAL UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c NORTHWEST A F UNIVERSITY   (China)

Author keywords

Highly pathogenic PRRSV; IL 10; IL 4; Immune responses; PRRSV

Indexed keywords

ARTERIVIRUS VACCINE; CH 1R; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOREXIA; ANTIBODY RESPONSE; ARTERIVIRUS; ARTERIVIRUS INFECTION; ARTICLE; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; HISTOPATHOLOGY; IMMUNE RESPONSE; INGUINAL LYMPH NODE; LETHARGY; LUNG; LUNG HILUS LYMPH NODE; LYMPH NODE; MESENTERY LYMPH NODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGLET; PROTEIN BLOOD LEVEL; PROVOCATION TEST; RECTUM TEMPERATURE; SPLEEN; SPLEEN INJURY; SUBMANDIBULAR LYMPH NODE; SUPPURATION; SWINE DISEASE; THYMUS; THYMUS ATROPHY; TISSUE LEVEL; TONSIL; TONSIL DISEASE; TREMOR; VACCINATION; VIREMIA; VIRUS DETECTION; VIRUS LOAD; VIRUS STRAIN; WEIGHT REDUCTION; WHEEZING;

ANIMALS; ANTIBODIES, VIRAL; BODY TEMPERATURE; HISTOCYTOCHEMISTRY; IMMUNIZATION; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-4; LYMPHOID TISSUE; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SWINE; VACCINES, ATTENUATED; VIRAL VACCINES; VIREMIA;

ANIMALIA; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS;

EID: 79960041123     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.05.004     Document Type: Article

References (39)

1. Aasted B., Bach P., Nielsen J., Lind P. Cytokine profiles in peripheral blood mononuclear cells and lymph node cells from piglets infected in utero with porcine reproductive and respiratory syndrome virus. Clin. Diagn. Lab. Immunol. 2002, 9:1229-1234.
2. Allende R., Laegreid W.W., Kutish G.F., Galeota J.A., Wills R.W., Osorio F.A. Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection. J. Virol. 2000, 74:10834-10837.
3. Charerntantanakul W., Platt R., Roth J.A. Effects of porcine reproductive and respiratory syndrome virus-infected antigen-presenting cells on T cell activation and antiviral cytokine production. Viral Immunol. 2006, 19:646-661.
4. Darwich L., Diaz I., Mateu E. Certainties, doubts and hypotheses in porcine reproductive and respiratory syndrome virus immunobiology. Virus Res. 2010, 154:123-132.
5. Diaz I., Darwich L., Pappaterra G., Pujols J., Mateu E. Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 2005, 86:1943-1951.
6. Diaz I., Darwich L., Pappaterra G., Pujols J., Mateu E. Different European-type vaccines against porcine reproductive and respiratory syndrome virus have different immunological properties and confer different protection to pigs. Virologie 2006, 351:249-259.
7. Done S.H., Paton D.J. Porcine reproductive and respiratory syndrome: clinical disease, pathology and immunosuppression. Vet. Rec. 1995, 136:32-35.
8. Feng W.H., Tompkins M.B., Xu J.S., Brown T.T., Laster S.M., Zhang H.X., McCaw M.B. Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus. Virologie 2002, 302:363-372.
9. Feng W.H., Tompkins M.B., Xu J.S., Zhang H.X., McCaw M.B. Analysis of constitutive cytokine expression by pigs infected in-utero with porcine reproductive and respiratory syndrome virus. Vet. Immunol. Immunopathol. 2003, 94:35-45.
10. Fickenscher H., Hor S., Kupers H., Knappe A., Wittmann S., Sticht H. The interleukin-10 family of cytokines. Trends Immunol. 2002, 23:89-96.
11. Galina L., Pijoan C., Sitjar M., Christianson W.T., Rossow K., Collins J.E. Interaction between Streptococcus suis serotype 2 and porcine reproductive and respiratory syndrome virus in specific pathogen-free piglets. Vet. Rec. 1994, 134:60-64.
12. Hu S.P., Zhang Z., Cai X.H., Tian Z.J., An T.Q., Wu D.L. Valuation of protective efficacy of PRRS attenuated vaccine and inactivated mutant PRRSV strains. Chinese J. Prev. Vet. Med. 2009, 31:392-396.
13. Kim W.I., Yoon K.J. Molecular assessment of the role of envelope-associated structural proteins in cross neutralization among different PRRS viruses. Virus Genes 2008, 37:380-391.
14. Kimman T.G., Cornelissen L.A., Moormann R.J., Rebel J.M., Stockhofe-Zurwieden N. Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology. Vaccine 2009, 27:3704-3718.
15. Labarque G.G., Nauwynck H.J., Van Reeth K., Pensaert M.B. Effect of cellular changes and onset of humoral immunity on the replication of porcine reproductive and respiratory syndrome virus in the lungs of pigs. J. Gen. Virol. 2000, 81:1327-1334.
16. Labarque G.G., Reeth K.V., Nauwynck H.J., Drexler C., Van Gucht S., Pensaert M. Impact of genetic diversity of European-type porcine reproductive and respiratory syndrome virus strains on vaccine efficacy. Vaccine 2004, 22:4183-4190.
17. Lauw F.N., Pajkrt D., Hack C.E., Kurimoto M., van Deventer S.J., van der Poll T. Proinflammatory effects of IL-10 during human endotoxemia. J. Immunol. 2000, 165:2783-2789.
18. Lawson S., Lunney J., Zuckermann F., Osorio F., Nelson E., Welbon C., Clement T., Fang Y., Wong S., Kulas K., Christopher-Hennings J. Development of an 8-plex Luminex assay to detect swine cytokines for vaccine development: assessment of immunity after porcine reproductive and respiratory syndrome virus (PRRSV) vaccination. Vaccine 2010, 28:5356-5364.
19. Li Y., Wang X., Bo K., Wang X., Tang B., Yang B., Jiang W., Jiang P. Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China. Vet. J. 2007, 174:577-584.
20. Liu Y., Shi W., Zhou E., Wang S., Hu S., Cai X., Rong F., Wu J., Xu M., Xu M., Li L. Dynamic changes in inflammatory cytokines in pigs infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Clin. Vaccine Immunol. 2010, 17:1439-1445.
21. Lopez O.J., Osorio F.A. Role of neutralizing antibodies in PRRSV protective immunity. Vet. Immunol. Immunopathol. 2004, 102:155-163.
22. Murtaugh M.P., Xiao Z., Zuckermann F. Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection. Viral Immunol. 2002, 15:533-547.
23. Meier W.A., Galeota J., Osorio F.A., Husmann R.J., Schnitzlein W.M., Zuckermann F.A. Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination. Virologie 2003, 309:18-31.
24. Nilubol D., Platt K.B., Halbur P.G., Torremorell M., Harris D.L. The effect of a killed porcine reproductive and respiratory syndrome virus (PRRSV) vaccine treatment on virus shedding in previously PRRSV infected pigs. Vet. Microbiol. 2004, 102:11-18.
25. Peng Y.T., Chaung H.C., Chang H.L., Chang H.C., Chung W.B. Modulations of phenotype and cytokine expression of porcine bone marrow-derived dendritic cells by porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 2009, 136:359-365.
26. Pesch S., Meyer C., Ohlinger V.F. New insights into the genetic diversity of European porcine reproductive and respiratory syndrome virus (PRRSV). Vet. Microbiol. 2005, 107:31-48.
27. Qiu H.J., Tian Z.J., Tong G.Z., Zhou Y.J., Ni J.Q., Luo Y.Z., Cai X.H. Protective immunity induced by a recombinant pseudorabies virus expressing the GP5 of porcine reproductive and respiratory syndrome virus in piglets. Vet. Immunol. Immunopathol. 2005, 106:309-319.
28. Rossow K.D., Bautista E.M., Goyal S.M., Molitor T.W., Murtaugh M.P., Morrison R.B., Benfield D.A., Collins J.E. Experimental porcine reproductive and respiratory syndrome virus infection in one-, four-, and 10-week-old pigs. J. Vet. Diagn. Invest. 1994, 6:3-12.
29. Shi K.C., Guo X., Ge X.N., Liu Q., Yang H.C. Cytokine mRNA expression profiles in peripheral blood mononuclear cells from piglets experimentally co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2. Vet. Microbiol. 2010, 140:155-160.
30. Suradhat S., Thanawongnuwech R. Upregulation of interleukin-10 gene expression in the leukocytes of pigs infected with porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 2003, 84:2755-2760.
31. Thanawongnuwech R., Thacker E.L. Interleukin-10, interleukin-12, and interferon-gamma levels in the respiratory tract following mycoplasma hyopneumoniae and PRRSV infection in pigs. Viral Immunol. 2003, 16:357-367.
32. Tian K., Yu X., Zhao T., Feng Y., Cao Z., Wang C., Hu Y., Chen X., Hu D., Tian X., Liu D., Zhang S., Deng X., Ding Y., Yang L., Zhang Y., Xiao H., Qiao M., Wang B., Hou L., Wang X., Yang X., Kang L., Sun M., Jin P., Wang S., Kitamura Y., Yan J., Gao G.F. Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PloS One 2007, 2:e526.
33. Tian Z.J., An T.Q., Zhou Y.J., Peng J.M., Hu S.P., Wei T.C., Jiang Y.F., Xiao Y., Tong G.Z. An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS. Vet. Microbiol. 2009, 138:34-40.
34. Tong G.Z., Zhou Y.J., Hao X.F., Tian Z.J., An T.Q., Qiu H.J. Highly pathogenic porcine reproductive and respiratory syndrome. China Emerg. Infect. Dis. 2007, 13:1434-1436.
35. Tschoeke S.K., Oberholzer C., LaFace D., Hutchins B., Moldawer L.L., Oberholzer A. Endogenous IL-10 regulates sepsis-induced thymic apoptosis and improves survival in septic IL-10 null mice. Scand. J. Immunol. 2008, 68:565-571.
36. Unanue E.R. Studies in listeriosis show the strong symbiosis between the innate cellular system and the T-cell response. Immunol. Rev. 1997, 158:11-25.
37. Wei T.C., Tian Z.J., An T.Q., Zhou Y.J., Xiao Y., Jiang Y.F., Hao X.F., Zhang S.R., Peng J.M., Qiu H.J., Tong G.Z. Development and application of Taq Man-MGB fluorescence quantitative RT-PCR assay for detection of porcine reproductive and respiratory syndrome virus. Chinese J. Prev. Vet. Med. 2008, 30:944-948.
38. Wesley R.D., Lager K.M., Kehrli M.E. Infection with Porcine reproductive and respiratory syndrome virus stimulates an early gamma interferon response in the serum of pigs. Can. J. Vet. Res. 2006, 70:176-182.
39. Xiao Z., Batista L., Dee S., Halbur P., Murtaugh M.P. The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load. J. Virol. 2004, 78:5923-5933.