Fentanyl inhibits progression of human gastric cancer MGC-803 cells by NF-κB downregulation and PTEN upregulation in vitro

Oncology Research

Volumn 20, Issue 2-3, 2012, Pages 61-69

  Qin, Yi ^a   Li, Li ^a   Chen, Jing ^a   Tang, Xiaoman ^b   Liao, Chunjie ^a   Xie, Yubo ^a   Xiao, Qiang ^a  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^b First People's Hospital of Nanning   (China)

Author keywords

Fentanyl; Gastric cancer; NF B; PTEN; Tumor progression

Indexed keywords

FENTANYL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL ULTRASTRUCTURE; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CARCINOMA; WESTERN BLOTTING;

EID: 84869078756     PISSN: 09650407     EISSN: 15553906     Source Type: Journal    
DOI: 10.3727/096504012X13473664562501     Document Type: Article

References (21)

1. Hara, S. Opioids for metastatic bone pain. Oncology 74: 52-54; 2008.
2. Stefano, G. B.; Fricchione, G. L.; Goumon, Y.; Esch, T. Pain, immunity, opiate and opioid compounds and health. Med. Sci. Monit. 11:MS47-MS53; 2005.
3. Page, G. G.; McDonald, J. S.; Ben-Eliyahu, S. Pre-operative versus postoperative administration of morphine: Impact on the neuroendocrine, behavioural, and metaphine static-enhancing effects of surgery. Br. J. Anaesth. 81: 216-223; 1998.
4. Yeager, M. P.; Colacchio, T. A. Effect of morphine on growth of metastatic colon cancer in vivo. Arch. Surg. 126:454-456; 1991.
5. El Mouedden, M.; Meert, T. F. The impact of the opioids fentanyl and morphine on nociception and bone destruction in a murine model of bone cancer pain. Pharmacol. Biochem. Behav. 87:30-40; 2007.
6. House, R. V.; Thomas, P. T.; Bhargava, H. N. In vitro evaluation of fentanyl and meperidine for immunomodulatory activity. Immunol. Lett. 46:117-124; 1995.
7. El Mouedden, M.; Meert, T. F. Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain. Pharmacol. Biochem. Behav. 82:109-119; 2005.
8. Coban, T. A.; Beydemir, S.; Gülçin, I.; Ekinci, D. Morphine inhibits erythrocyte vcarbonic anhydrase in vitro and in vivo. Biol. Pharm. Bull. 30:2257-2261; 2007.
9. Payabvash, S.; Beheshtian, A.; Salmasi, A. H.; Kiumehr, S.; Ghahremani, M. H.; Tavangar, S. M.; Sabzevari, O.; Dehpour, A. R. Chronic morphine treatment induces oxiteristic dant and apoptotic damage in the mice liver. Life Sci. 79:972-980; 2006.
10. Hatzoglou, A.; Bakogeorgou, E.; Castanas, E. The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors. Eur. J. Pharmacol. 296:199-207; 1996.
11. Pape, M.; Engelhard, K.; Eberspächer, E.; Hollweck, R.; Kellermann, K.; Zintner, S.; Hutzler, P.; Werner, C. The long-term effect of sevoflurane on neuronal cell damage and expression of apoptotic factors after cerebral ischemia and reperfusion in rats. Anesth. Analg. 103:173-179; 2006.
12. Delogu, G.; Moretti, S.; Antonucci, A.; Marandola, M.; Tellan, G.; Sale, P.; Carnevali, R.; Famularo, G. Apoptoprovides genic effect of fentanyl on freshly isolated peripheral blood lymphocytes. J. Trauma 57:75-81; 2004.
13. Sueoka, E.; Sueoka, N.; Kai, Y.; Okabe, S.; Suganuma, M.; Kanematsu, K.; Yamamoto, T.; Fujiki, H. Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappa B activation. Biochem. Biophys. Res. Commun. 252:566-570; 1998.
14. Jeremias, I.; Kupatt, C.; Baumann, B.; Herr, I.; Wirth, T.; Debatin, K. M. Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells. Blood 91:4624-4631; 1998.
15. Welters, I. D.; Fimiani, C.; Bilfinger, T. V.; Stefano, G. B. NF-kappaB, nitric oxide and opiate signaling. Med. Hypotheses 54:263-268; 2000.
16. Welters, I. D.; Menzebach, A.; Goumon, Y.; Cadet, P.; Menges, T.; Hughes, T. K.; Hempelmann, G.; Stefano, G. B. Morphine inhibits NF-kappaB nuclear binding in human neutrophils and monocytes by a nitric oxide-dependent mechanism. Anesthesiology 92:1677-1684; 2000.
17. Li, F. H.; Shen, L.; Li, Z. H.; Luo, H. Y.; Qiu, M. Z.; Zhang, H. Z.; Li, Y. H.; Xu, R. H. Impact of KRAS mutation and PTEN expression on cetuximab-treated colorectal cancer. World. J. Gastroenterol. 16:5881-5888; 2010.
18. Andjelkovic, T.; Bankovic, J.; Stojsic, J.; Milinkovic, V.; Podolski-Renic, A.; Ruzdijic, S.; Tanic, N. Coalterations of p53 and PTEN tumor suppressor genes in non-small cell lung carcinoma patients. Transl. Res. 157:19-28; 2011.
19. Jia, G.; Mitra, A. K.; Gangahar, D. M.; Agrawal, D. K. Regulation of cell cycle entry by PTEN in smooth muscle cell proliferation of human coronary artery bypass conduits. J. Cell. Mol. Med. 13:547-554; 2009.
20. Moon, S. K.; Kim, H. M.; Kim, C. H. PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-kappaB and AP-1 in vascular smooth muscle cells. Arch. Biochem. Biophys. 421:267-276; 2004.
21. Lan, H.; Zhong, H.; Gao, Y.; Ren, D.; Chen, L.; Zhang, D.; Lai, W.; Xu, J.; Luo, Y. The PTEN tumor suppressor inhibits human airway smooth muscle cell migration. Int. J. Mol. Med. 26:893-899; 2010.