A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 12, 2012, Pages 2204-2211

  Jetzt, Amanda E ^a   Cheng, Ju Shun ^a   Li, Xiao Ping ^b   Tumer, Nilgun E ^b   Cohick, Wendie S ^a  

^a RUTGERS UNIVERSITY   (United States)

^b Rutgers University   (United States)

Author keywords

Apoptosis; Mammalian cells; Mutants; Ribosome depurination; Ricin toxin A chain; Signal transduction

Indexed keywords

CASPASE 3; CASPASE 7; MUTANT PROTEIN; PLASMID VECTOR; RICIN A; SIGNAL PEPTIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MAMMAL CELL; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; TRANSIENT TRANSFECTION; WILD TYPE;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 7; CATTLE; CELL LINE; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; NUCLEOSOMES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BIOSYNTHESIS; PROTEIN SORTING SIGNALS; RIBOSOMES; RICIN; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 84869078124     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.09.004     Document Type: Article

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