Identification of a novel functional domain of ricin responsible for its potent toxicity

Journal of Biological Chemistry

Volumn 286, Issue 14, 2011, Pages 12166-12171

  Dai, Jianxing ^a,b   Zhao, Lei ^a   Yang, Haiou ^a,c   Guo, Huaizu ^c   Fan, Kexing ^a,b   Wang, Huaqing ^a,b   Qian, Weizhu ^a,b   Zhang, Dapeng ^a,b   Li, Bohua ^a,b   Wang, Hao ^a,b   Guo, Yajun ^a,b,c,d  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b National Engineering Research Center for Antibody Medicine   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOLOGICAL ACTIVITIES; BIOMEDICAL RESEARCH; CATALYTIC ACTIVITY; CELL KILLING; CLINICAL USE; DEPURINATION; FUNCTIONAL DOMAINS; GLYCOSIDASES; HUMAN CELLS; IMMUNOTOXINS; IN-VIVO; NEUTRALIZING ANTIBODIES; PROTEIN SYNTHESIS; RIBOSOME-INACTIVATING PROTEIN; RICIN A CHAINS; TERTIARY STRUCTURES;

ANIMALS; ENZYME INHIBITION; TOXICITY;

CATALYST ACTIVITY;

MONOCLONAL ANTIBODY; RICIN;

ALPHA CHAIN; ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DEPURINATION; PROTEIN DOMAIN; PROTEIN SYNTHESIS INHIBITION; PROTEIN TERTIARY STRUCTURE; REGULATORY MECHANISM;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL-FREE SYSTEM; CERCOPITHECUS AETHIOPS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; MOLECULAR DYNAMICS SIMULATION; RICIN; RNA, RIBOSOMAL; VERO CELLS;

ANIMALIA;

EID: 79953308083     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.196584     Document Type: Article

References (32)

1. Stirpe, F., and Battelli, M. G. (2006) Cell Mol. Life Sci. 63, 1850-1866
2. Hartley, M. R., and Lord, J. M. (2004) Mini. Rev. Med. Chem. 4, 487-492
3. Motto, M., and Lupotto, E. (2004) Mini. Rev. Med. Chem. 4, 493-503
4. Endo, Y., Mitsui, K., Motizuki, M., and Tsurugi, K. (1987) J. Biol. Chem. 262, 5908-5912
5. Day, P. J., Ernst, S. R., Frankel, A. E., Monzingo, A. F., Pascal, J. M., Molina-Svinth, M. C., and Robertus, J. D. (1996) Biochemistry 35, 11098-11103
6. Morris, K. N., and Wool, I. G. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 4869-4873
7. Kim, Y., Mlsna, D., Monzingo, A. F., Ready, M. P., Frankel, A., and Robertus, J. D. (1992) Biochemistry 31, 3294-3296
8. Ready, M. P., Kim, Y., and Robertus, J. D. (1991) Proteins 10, 270-278
9. Ho, M. C., Sturm, M. B., Almo, S. C., and Schramm, V. L. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 20276-20281
10. Wang, Y., Zhang, X., Yuan, L., Xu, T., Rao, Y., Li, J., and Dai, H. (2008) Biochem. Biophys. Res. Commun. 372, 902-906
11. Conti-Fine, B. M., Lei, S., and Mclane, K. E. (1996) Annu. Rev. Biophys. Biomol. Struct. 25, 197-229
12. Kim, Y., and Robertus, J. D. (1992) Protein Eng. 5, 775-779
13. Rutenber, E., Katzin, B. J., Ernst, S., Collins, E. J., Mlsna, D., Ready, M. P., and Robertus, J. D. (1991) Proteins 10, 240-250
14. Maddaloni, M., Cooke, C., Wilkinson, R., Stout, A. V., Eng, L., and Pincus, S. H. (2004) J. Immunol. 172, 6221-6228
15. Sturm, M. B., and Schramm, V. L. (2009) Anal Chem. 81, 2847-2853
16. Case, D. A., Cheatham, T. E., 3rd, Darden, T., Gohlke, H., Luo, R., Merz, K. M., Jr., Onufriev, A., Simmerling, C., Wang, B., and Woods, R. J. (2005) J. Comput. Chem. 26, 1668-1688
17. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
18. Kyte, J., and Doolittle, R. F. (1982) J. Mol. Biol. 157, 105-132
19. Hopp, T. P., and Woods, K. R. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 3824-3828
20. Montfort, W., Villafranca, J. E., Monzingo, A. F., Ernst, S. R., Katzin, B., Rutenber, E., Xuong, N. H., Hamlin, R., and Robertus, J. D. (1987) J. Biol. Chem. 262, 5398-5403
21. Závodszky, P., Kardos, J., Svingor, and Petsko, G. A. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 7406-7411
22. Daniel, R. M., Dunn, R. V., Finney, J. L., and Smith, J. C. (2003) Annu. Rev. Biophys. Biomol. Struct. 32, 69-92
23. Pan, Y., and Nussinov, R. (2010) PLoS Comput. Biol. 6
24. Karginov, A. V., Ding, F., Kota, P., Dokholyan, N. V., and Hahn, K. M. (2010) Nat. Biotechnol. 28, 743-747
25. Kitaoka, Y. (1998) Eur. J. Biochem. 257, 255-262
26. Bowler, B. E. (2007) Mol. Biosyst. 3, 88-99
27. Rose, G. D., Fleming, P. J., Banavar, J. R., and Maritan, A. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 16623-16633
28. Pace, C. N., Shirley, B. A., McNutt, M., and Gajiwala, K. (1996) FASEB J. 10, 75-83
29. Pace, C. N. (1995) Methods Enzymol. 259, 538-554
30. Olsnes, S., Fernandez-Puentes, C., Carrasco, L., and Vazquez, D. (1975) Eur. J. Biochem. 60, 281-288
31. Chang, Q., Zhong, Z., Lees, A., Pekna, M., and Pirofski, L. (2002) Infect. Immun. 70, 4977-4986
32. Zolla-Pazner, S., and Cardozo, T. (2010) Nat. Rev. Immunol. 10, 527-535