Constitutive expression of IGF-binding protein-3 by mammary epithelial cells alters signaling through Akt and p70S6 kinase

Journal of Molecular Endocrinology

Volumn 29, Issue 1, 2002, Pages 153-162

  Grill, C J ^a   Sivaprasad, U ^a   Cohick, W S ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEUCINE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S6 KINASE; SERINE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CELL GROWTH; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENETIC TRANSFECTION; GROWTH REGULATION; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REACTION TIME; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CATTLE; CYTOLOGY; ENZYME ACTIVATION; METABOLISM; PHOSPHORYLATION; UDDER;

ANIMAL; BLOTTING, WESTERN; CATTLE; CELL LINE; ENZYME ACTIVATION; EPITHELIAL CELLS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MAMMAE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; ANIMALS; MAMMARY GLANDS, ANIMAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 0036668576     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0290153     Document Type: Article

References (41)

1. Insulin signal transduction through protein kinase cascades
2. Regulation of insulin-like growth factor binding protein-3 messenger ribonucleic acid expression by insulin-like growth factor I
3. Antiproliferative and pro-apoptotic activities of insulin-like growth factor-binding protein-3
4. Structural analogs of human insulin-like growth factor I with reduced affinity for serum binding proteins and the Type 2 insulin-like growth factor receptor
5. Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells
6. Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line
7. Insulin-like growth factor binding proteins and their role in controlling IGF actions
8. Competition for binding to insulin-like growth factor (IGF) binding protein-2, 3, 4, and 5 by the IGFs and IGF analogs
9. Enhanced expression of dihydrofolate reductase by bovine kidney epithelial cells results in altered cell morphology, IGF-I responsiveness, and IGF binding protein-3 expression
10. Regulation of insulin-like growth factor binding protein synthesis by a bovine mammary epithelial cell line
11. Potentiation of insulin-like growth factor (IGF) action by IGF-binding protein-3: Studies of underlying mechanism
12. Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the phosphatidylinositol-3-kinase pathway and is associated with alteration in protein kinase B/AKT sensitivity
13. Phosphorylation of insulin-like growth factor binding proteins
14. Cellular survival: A play in three Akts
15. Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-1 stimulated DNA synthesis in human skin fibroblasts
16. Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling
17. Signaling through the smad pathway by insulin-like growth factor-binding protein-3 in breast cancer cells
18. Cellular actions of insulin-like growth factor binding proteins
19. Insulin-like growth factor binding protein-3 mediates IGF-I action in a bovine mammary epithelial cell line independent of an IGF interaction
20. Identification of the major sites of phosphorylation in IGF binding protein-3
21. Establishment of bovine mammary epithelial cells (MAC-T): An in vitro model for bovine lactation
22. Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions
23. Nuclear localization of insulin-like growth factor binding protein-3 in a lung cancer cell line
24. Molecular and cellular aspects of the insulin-like growth factor I receptor
25. Nuclear transport of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in opossum kidney cells
26. Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis
27. Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells
28. Insulin-like growth factor binding protein-3 is secreted as a phosphoprotein by human breast cancer cells
29. The expression of the IGF family and GH receptor in the bovine mammary gland
30. Role of growth hormone and insulin-like growth factor-I in mammary development
31. The modular phosphorylation and activation of p70s6k
32. Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-B1 on programmed cell death through a p53-and IGF-independent mechanism
33. The insulin-like growth factors (IGF) and IGF type I receptor during postnatal growth of the murine mammary gland: Sites of messenger ribonucleic acid expression and potential functions
34. Insulin-like growth factor (IGF) binding protein-3 inhibits type 1 IGF receptor activation independently of its IGF binding affinity
35. Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development
36. Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development
37. Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid
38. Insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cells
39. Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors
40. Expression of ovine insulin-like growth factor-1 (IGF-1) stimulates alveolar bud development in mammary glands of transgenic mice
41. Intranuclear localization of insulin-like growth factor binding protein-3 (IGFBP-3) during cell division in human keratinocytes