Limited SP17 expression within tumors diminishes its therapeutic potential

Tissue Antigens

Volumn 80, Issue 6, 2012, Pages 523-527

  Gjerstorff, M F ^a   Ditzel, H J ^a,b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cancer antigen; G antigen; Immunotherapy; Melanoma associated antigen A; Sperm protein 17

Indexed keywords

GAGE ANTIGEN; MELANOMA ANTIGEN 1; TUMOR ANTIGEN; TUMOR ANTIGEN SPERM PROTEIN 17; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY REACTION; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CANCER IMMUNOLOGY; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; DRUG TARGETING; ENDOMETRIUM CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL;

ANTIGENS, NEOPLASM; ANTIGENS, SURFACE; CANCER VACCINES; CARRIER PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; MALE; MELANOMA-SPECIFIC ANTIGENS; NEOPLASMS;

EID: 84869074730     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/tan.12015     Document Type: Article

References (23)

1. Gjerstorff MF, Burns J, Ditzel HJ. Cancer-germline antigen vaccines and epigenetic enhancers: future strategies for cancer treatment. Expert Opin Biol Ther 2010: 10: 1061-75.
2. Grizzi F, Chiriva-Internati M, Franceschini B et al. Immunolocalization of sperm protein 17 in human testis and ejaculated spermatozoa. J Histochem Cytochem 2003: 51: 1245-8.
3. McLeskey SB, Dowds C, Carballada R, White RR, Saling PM. Molecules involved in mammalian sperm-egg interaction. Int Rev Cytol 1998: 177: 57-113.
4. Grizzi F, Gaetani P, Franceschini B et al. Sperm protein 17 is expressed in human nervous system tumours. BMC Cancer 2006: 6: 23.
5. Lim SH, Wang Z, Chiriva-Internati M, Xue Y. Sperm protein 17 is a novel cancer-testis antigen in multiple myeloma. Blood 2001: 97: 1508-10.
6. Straughn JM Jr, Shaw DR, Guerrero A et al. Expression of sperm protein 17 (Sp17) in ovarian cancer. Int J Cancer 2004: 108: 805-11.
7. Gupta G, Sharma R, Chattopadhyay TK, Gupta SD, Ralhan R. Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer. Int J Cancer 2007: 120: 1739-47.
8. Li FQ, Liu Q, Han YL, Wu B, Yin HL. Sperm protein 17 is highly expressed in endometrial and cervical cancers. BMC Cancer 2010: 10: 429.
9. Grizzi F, Chiriva-Internati M, Franceschini B et al. Sperm protein 17 is expressed in human somatic ciliated epithelia. J Histochem Cytochem 2004: 52: 549-54.
10. Grizzi F, Franceschini B, Hermonat PL, Liu Y, Chiriva-Internati M. Some remarks on the somatic expression of sperm protein 17. Int J Cancer 2004: 111: 972-3 author reply 4.
11. Lea IA, Adoyo P, O'Rand MG. Autoimmunogenicity of the human sperm protein Sp17 in vasectomized men and identification of linear B cell epitopes. Fertil Steril 1997: 67: 355-61.
12. Chiriva-Internati M, Wang Z, Xue Y, Bumm K, Hahn AB, Lim SH. Sperm protein 17 (Sp17) in multiple myeloma: opportunity for myeloma-specific donor T cell infusion to enhance graft-versus-myeloma effect without increasing graft-versus-host disease risk. Eur J Immunol 2001: 31: 2277-83.
13. Chiriva-Internati M, Wang Z, Salati E, Wroblewski D, Lim SH. Successful generation of sperm protein 17 (Sp17)-specific cytotoxic T lymphocytes from normal donors: implication for tumour-specific adoptive immunotherapy following allogeneic stem cell transplantation for Sp17-positive multiple myeloma. Scand J Immunol 2002: 56: 429-33.
14. Chiriva-Internati M, Wang Z, Salati E, Bumm K, Barlogie B, Lim SH. Sperm protein 17 (Sp17) is a suitable target for immunotherapy of multiple myeloma. Blood 2002: 100: 961-5.
15. Dadabayev AR, Wang Z, Zhang Y, Zhang J, Robinson WR, Lim SH. Cancer immunotherapy targeting Sp17: when should the laboratory findings be translated to the clinics? Am J Hematol 2005: 80: 6-11.
16. Nakazato T, Kanuma T, Tamura T, Faried LS, Aoki H, Minegishi T. Sperm protein 17 influences the tissue-specific malignancy of clear cell adenocarcinoma in human epithelial ovarian cancer. Int J Gynecol Cancer 2007: 17: 426-32.
17. Li FQ, Han YL, Liu Q, Wu B, Huang WB, Zeng SY. Overexpression of human sperm protein 17 increases migration and decreases the chemosensitivity of human epithelial ovarian cancer cells. BMC Cancer 2009: 9: 323.
18. Gjerstorff MF, Johansen LE, Nielsen O, Kock K, Ditzel HJ. Restriction of GAGE protein expression to subpopulations of cancer cells is independent of genotype and may limit the use of GAGE proteins as targets for cancer immunotherapy. Br J Cancer 2006: 94: 1864-73.
19. Vermeij R, Daemen T, de Bock GH et al. Potential target antigens for a universal vaccine in epithelial ovarian cancer. Clin Dev Immunol 2010.
20. Wang Z, Zhang Y, Ramsahoye B, Bowen D, Lim SH. Sp17 gene expression in myeloma cells is regulated by promoter methylation. Br J Cancer 2004: 91: 1597-603.
21. Bazhin AV, Wiedemann N, Schnolzer M, Schadendorf D, Eichmuller SB. Expression of GAGE family proteins in malignant melanoma. Cancer Lett 2007: 251: 258-67.
22. Wischnewski F, Pantel K, Schwarzenbach H. Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. Mol Cancer Res 2006: 4: 339-49.
23. Lacy HM, Sanderson RD. Sperm protein 17 is expressed on normal and malignant lymphocytes and promotes heparan sulfate-mediated cell-cell adhesion. Blood 2001: 98: 2160-5.