Autoimmunogenicity of the human sperm protein Sp17 in vasectomized men and identification of linear B cell epitopes

Fertility and Sterility

Volumn 67, Issue 2, 1997, Pages 355-361

  Lea, Isabel A ^a   Adoyo, Pius ^b   O'Rand, Michael G ^c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b INSTITUTE OF PRIMATE RESEARCH   (Kenya)

^c NONE

Author keywords

antisperm antibodies; autoantigen; HSp17

Indexed keywords

AUTOANTIBODY; EPITOPE; SPERM ANTIBODY; SPERM PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOGENICITY; PRIORITY JOURNAL; VASECTOMY;

EID: 0031026505     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0015-0282(97)81923-1     Document Type: Article

References (23)

1. Hendry WF. The significance of antisperm antibodies measurement and management. Clin Endocrinol (Oxf) 1992; 36:219-21.
2. Hjort T, Meinertz H. Anti-sperm antibodies and immune subfertility. Hum Reprod 1988;3:59-62.
3. Bronson R, Cooper G, Rosenfeld D. Sperm antibodies: their role in infertility. Fertil Steril 1984;42:171-83.
4. Fuchs EF, Alexander NJ. Immunologie considerations before and after vasovasostomy. Fertil Steril 1983;40:497-9.
5. Meinertz H, Linnet L, Fogh-Anderson P, Hjort T. Antisperm antibodies and fertility after vasovasostomy: a follow-up study of 216 men. Fertil Steril 1990;54:315-21.
6. Barratt CLR, Harrison PE, Robinson A, Cooke ID. Antisperm antibodies and lymphocyte subsets in semen - not a simple relationship. J Androl 1990;13:50-8.
7. Clarke GN. Immunoglobulin class and regional specificity of antispermatozoal autoantibodies blocking cervical mucus penetration. Am J Reprod Immunol Microbiol 1988;16: 135-8.
8. Barratt CLR, Dunphy BC, McLead I, Cooke ID. The poor prognostic value of low to moderate levels of sperm surface-bound antibodies. Hum Reprod 1992;7:95-8.
9. Wang C, Baker HWG, Jennings MG, Burger HG, Lutjen P. Interaction between human cervical mucus and sperm surface antibodies. Fertil Steril 1985;44:484-8.
10. Kremer J, Jager S. Characteristics of anti-spermatozoal antibodies responsible for the shaking phenomenon with special regard to the immunoglobulin class and antigen reactive sites. Int J Androl 1980;3:143-52.
11. Gupta SK, Alexander NJ. Characterization of spermatozoa antigens by monoclonal and polyclonal antibodies. In: Alexander NJ, Griffin D, Spieler JM, GMH, editors. Gamete interaction: prospects for immunocontraception. New York: Wiley-Liss, 1990:345-57.
12. Paradisi R, Pession A, Bellavia E, Focacci M, Flamigni C. Characterization of human sperm antigens reacting with antisperm antibodies from autologous sera and seminal plasma in a fertile population. J Reprod Immunol 1995;28: 61-73.
13. Snow K, Ball GD. Characterization of human sperm antigens and antisperm antibodies in infertile patients. Fertil Steril 1992;58:1011-9.
14. Primakoff P, Lathrop W, Bronson R. Identification of human sperm surface glycoproteins recognized by autoantisera from immune infertile men, women and vasectomized men. Biol Reprod 1990;42:929-42.
15. Auer J, Pignot I, De Almeida M. Identification of human sperm surface glycoproteins by sperm membrane-specific autoantibodies. Hum Reprod 1995;10:551-7.
16. Richardson RT, Yamasaki N, O'Rand MG. Sequence of a rabbit sperm zona pellucida binding protein and localization during the acrosome reaction. Dev Biol 1994;165:688-701.
17. O'Rand MG, Porter JP. Isolation of a sperm membrane sialoglycoprotein autoantigen from rabbit testis. J Immunol 1979; 122:1248-54.
18. O'Rand MG, Porter JP. Purification of rabbit sperm autoantigens by preparative SDS gel electrophoresis: amino acid and carbohydrate content of RSA-1. Biol Reprod 1982;27:713-21.
19. Lea IA, Richardson RT, Widgren EE, O'Rand MG. Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. Biochim Biophys Acta 1996;1307:263-6.
20. Kong M, Richardson RT, Widgren EE, O'Rand MG. Sequence and localization of the mouse autoantigenic protein, Sp17. Biol Reprod 1995;53:579-90.
21. Batova I, O'Rand MG. Histone-binding domains in a nuclear autoantigenic sperm protein. Biol Reprod 1996;54:1238-44.
22. O'Rand MG, Widgren EE. Identification of sperm antigen targets for immuno-contraception: B-cell epitope analysis of Sp17. Reprod Fertil Dev 1994;6:289-96.
23. Pauls JD, Edworthy SM, Fitzler MJ. Epitope mapping of histone (H5) with systemic lupus erythematosus, procainamideinduced lupus and hydralazine-induced lupus sera. Mol Immunol 1993;30:709-19.