Systemic alterations in phospholipid concentrations of blood plasma in patients with thyroid carcinoma: An in-vitro 31P high-resolution NMR study

NMR in Biomedicine

Volumn 13, Issue 1, 2000, Pages 8-13

  Raffelt, Klaus ^a   Moka, Detlef ^a   Süllentrop, Frauke ^a   Dietlein, Markus ^a   Hahn, Josef ^a   Schicha, Harald ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Blood plasma; Hypothyroidism; In vitro 31P high resolution NMR; Phospholipids; Thyroid cancer

Indexed keywords

LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; SPHINGOMYELIN;

ADULT; ARTICLE; CANCER REGRESSION; CLINICAL ARTICLE; CONTROLLED STUDY; EUTHYROIDISM; FEMALE; HUMAN; HYPOTHYROIDISM; MALE; METASTASIS; PHOSPHOLIPID BLOOD LEVEL; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; THYROID CARCINOMA; WHOLE BODY SCINTISCANNING;

EID: 0034093624     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1492(200002)13:1<8::AID-NBM602>3.0.CO;2-X     Document Type: Article

References (23)

1. Barclay, M., Skipski, V. P., Terebus-Kekish, O., Greene, E. M., Kaufman, R. J. and Stock, C. C. Effects of cancer upon high-density and other lipoproteins. Cancer Res. 30, 2420-2430 (1970).
2. Nydegger, U. E. and Butler, R. E. Serum lipoprotein levels in patients with cancer. Cancer Res. 32, 1756-1760 (1972).
3. Ruiz-Cabello, J. and Cohen, J. S. Phospholipid metabolites as indicators of cancer cell function. NMR Biomed. 5, 226-233 (1992).
4. Das, S. C. and Isichei, U. P. Serum and thyroid tissue lipids in patients with thyroid tumors in euthyroidism. Ind. J. Exp. Biol. 27, 538-544 (1989).
5. Russel, P., Lean, C. L., Delbridge, L., May, G. L., Dowd, S. and Mountford, C. E. Proton magnetic resonance and human thyroid neoplasia I. discrimination between benign and malignant neoplasms. Am. J. Med. 96, 383-388 (1994).
6. 31P magnetic resonance spectroscopy. Nuklearmed. 30(3), 77-83 (1991).
7. Engler, H. and Riesen, W. F. Effect of thyroid function on concentrations of lipoprotein(a). Clin. Chem. 39, 2466-2469 (1993).
8. Hylander, B. and Rosenqvist, U. Time course effect of thyroxine on serum lipoprotein concentrations in hypothyroid subjects. Acta Med. Scand. 211, 287-291 (1982).
9. Franklyn, J. A., Daykin, J., Betteridge, J., Hughes, E. A., Holder, R., Jones, S. R. and Sheppard, M. C. Thyroxine replacement therapy and circulating lipid concentrations. Clin. Endocrinol. 38, 453-459 (1993).
10. Pazos, F., Alvarez, J. J., Rubies-Prat, J., Varela, C. and Lasuncion, M. A. Long term thyroid hormone replacement therapy and levels of lipoprotein(a) and other lipoproteins. J. Clin. Endocrinol. Metab. 80, 562-566 (1995).
11. 31P NMR spectroscopy to monitor chemotherapy-associated changes of serum phospholipids in patients with malignant lymphomas. Magn. Reson. Med. 35, 449-456 (1996).
12. 31P MRS spectra of sera from patients with multiple myeloma. NMR Biomed. 8, 127-132 (1995).
13. 31P-MRS (magnetic resonance spectroscopy) spectra of sera from patients with acute leukemia. Biochim. Biophvs. Acta, 1360, 71-83 (1997).
14. 31P NMR spectroscopy in clinical analysis of changes of serum phospholipids in leukemia, lymphoma and some other non-haematological cancers. Anticancer Res. 16, 1587-1594 (1996).
15. Podo, F. and de Certaines, J. D. Magnetic resonance spectroscopy in cancer: phospholipid, neutral lipid and lipoprotein metabolism and function. Anticancer Res. 16, 1305-1316 (1996).
16. Engan, T. Magnetic resonance spectroscopy of blood plasma lipoproteins in malignant disease: methological aspects and clinical relevance. Anticancer Res. 16, 1461-1472 (1996).
17. de Certaines, J. D., Nadal, L., Leray, G., Serrai, H. and Lewa, C. J. Proton nuclear magnetic resonance spectroscopy of plasma lipoprotein: technical problems and potential interest in cancer disease. Anticancer Res. 16, 1451-1460 (1996).
18. 31P NMR spectroscopy. Anal. Biochem. 185, 299-303 (1990).
19. Valente, W. A., Vitti, P., Kohn, L. D., Brandi, M. L., Rotella, C. M., Toccafondi, R., Tramontano, D., Aloi, S. M. and Amtesi-Impiombato, F. S. The relationship of growth and adenylate cyclase activity in cultured thyroid cells: separate bioeffects of thyrotropin. Endocrinology 112, 71-79 (1983).
20. 13C enriched metabolites from cell suspensions incubated in deuterated media. Magn. Reson. Med., 36, 359-365 (1996).
21. 31P MRS studies on experimental tumors treated with tumor necrosis factor. Acta Med. Rom. 30, 295-299 (1992).
22. Benvenga, S. and Robbins, J. Altered thyroid hormone binding to plasma lipoproteins in hypothyroidism. Thyroid 6, 595-600 (1996).
23. Arem, R., Escalante, D. A., Arem, N., Morrisett, J. D. and Patsch, W. Lipoprotein fractions in patients with grade I hypothyroidism: the effect of levothyroxine therapy. Thyroidol. Clin. Exp. 8, 15-20 (1996).