Adrenal inhibition following a single dose of etomidate in intubated traumatic brain injury victims

Canadian Journal of Emergency Medicine

Volumn 14, Issue 5, 2012, Pages 270-282

  Archambault, Patrick ^a,b   Dionne, Clermont E ^b   Lortie, Gilles ^c,d   LeBlanc, François ^b   Rioux, Anik ^e   Larouche, Geneviève ^b  

^a Centre Hospitalier Affilié Universitaire de Lévis   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c UNIVERSITÉ LAVAL   (Canada)

^d Hotel Dieu de Levis Hospital   (Canada)

^e Hô pital de Gatineau   (Canada)

Author keywords

Adrenal insufficiency; Etomidate; Traumatic brain injury

Indexed keywords

ANESTHETIC AGENT; CORTICOTROPIN; ETOMIDATE; HYDROCORTISONE;

ADOLESCENT; ADRENAL INSUFFICIENCY; AGE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG FATALITY; DRUG MEGADOSE; EMERGENCY CARE; EMERGENCY WARD; FEMALE; HORMONAL REGULATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; INCIDENCE; INTUBATION; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; RISK FACTOR; SEPTIC SHOCK; SINGLE DRUG DOSE; TRAUMATIC BRAIN INJURY;

ADRENAL GLANDS; ADRENAL INSUFFICIENCY; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; ANESTHETICS, INTRAVENOUS; BRAIN INJURIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOMIDATE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; INTUBATION, INTRATRACHEAL; MALE; MIDDLE AGED; QUEBEC; RISK FACTORS; YOUNG ADULT;

EID: 84869048667     PISSN: 14818035     EISSN: None     Source Type: Journal    
DOI: 10.2310/8000.2012.110560     Document Type: Article

References (42)

1. Bergen JM, Smith DC. A review of etomidate for rapid sequence intubation in the emergency department. J Emerg Med 1997;15:221-30, doi:10.1016/S0736-4679(96)00350-2.
2. SagarinMJ, Barton ED, Chng YM, et al. Airway management by US and Canadian emergency medicine residents: a multicenter analysis of more than 6,000 endotracheal intubation attempts. Ann Emerg Med 2005;46:328-36, doi:10.1016/j.annemergmed.2005.01.009.
3. Sakles JC, Laurin EG, Rantapaa AA, et al. Airway management in the emergency department: a one-year study of 610 tracheal intubations. Ann Emerg Med 1998;31:325-32, doi:10.1016/S0196-0644(98)70342-7.
4. Walls RM. Manual of emergency airway management. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2004.
5. Marx JA, Hockberger RS, Walls RM, et al. Rosen's emergency medicine: concepts and clinical practice. 6th ed. Philadelphia: Mosby/Elsevier; 2006.
6. Allolio B, Dö rr H, Stuttmann R, et al. Effect of a single bolus of etomidate upon eight major corticosteroid hormones and plasma ACTH. Clin Endocrinol (Oxf) 1985;22: 281-6, doi:10.1111/j.1365-2265.1985.tb03241.x.
7. Wagner RL, White PF. Etomidate inhibits adrenocortical function in surgical patients. Anesthesiology 1984;61:647-51, doi:10.1097/00000542-198412000-00003.
8. Fragen RJ, Shanks CA, Molteni A, et al. Effects of etomidate on hormonal responses to surgical stress. Anesthesiology 1984; 61:652-6, doi:10.1097/00000542-198412000-00004.
9. Duthie DJ, Fraser R, Nimmo WS. Effect of induction of anaesthesia with etomidate on corticosteroid synthesis in man. Br J Anaesth 1985;57:156-9, doi:10.1093/bja/57.2.156.
10. Crozier TA, Beck D, Schlaeger M, et al. Endocrinological changes following etomidate, midazolam, or methohexital for minor surgery. Anesthesiology 1987;66:628-35, doi:10.1097/00000542-198705000-00006.
11. Absalom A, Pledger D, Kong A. Adrenocortical function in critically ill patients 24 h after a single dose of etomidate. Anaesthesia 1999;54:861-7, doi:10.1046/j.1365-2044.1999.01003.x.
12. Schenarts CL, Burton JH, Riker RR. Adrenocortical dysfunction following etomidate induction in emergency department patients. Acad Emerg Med 2001;8:1-7, doi: 10.1111/j.1553-2712.2001.tb00537.x.
13. Vinclair M, Broux C, Faure P, et al. Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. Intensive Care Med 2008;34:714-9, doi:10.1007/s00134-007-0970-y.
14. Bloomfield R, Noble DW. Etomidate and fatal outcome-even a single bolus dose may be detrimental for some patients. Br J Anaesth 2006;97:116-7, doi:10.1093/bja/ael124.
15. Annane D. ICU physicians should abandon the use of etomidate! Intensive Care Med 2005;31:325-6, doi:10.1007/s00134-005-2560-1.
16. Morris C, McAllister C. Etomidate for emergency anaesthesia; mad, bad and dangerous to know? Anaesthesia 2005; 60:737-40, doi:10.1111/j.1365-2044.2005.04325.x.
17. JacksonWLJr. Shouldwe use etomidate as an induction agent for endotracheal intubation in patients with septic shock? A critical appraisal. Chest 2005;127:1031-8, doi:10.1378/chest.127.3.1031.
18. Hildreth AN, Mejia VA, Maxwell RA, et al. Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study. J Trauma 2008;65:573-9, doi:10.1097/TA.0b013e31818255e8.
19. Jabre P, Combes X, Lapostolle F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet 2009;374: 293-300, doi:10.1016/S0140-6736(09)60949-1.
20. Hohl CM, Kelly-Smith CH, Yeung TC, et al. The effect of a bolus dose of etomidate on cortisol levels, mortality, and health services utilization: a systematic review. Ann Emerg Med 2010;56:105-13 e5.
21. Bruns J Jr, Hauser WA. The epidemiology of traumatic brain injury: a review. Epilepsia 2003;44 Suppl 10:2-10, doi:10.1046/j.1528-1157.44.s10.3.x.
22. Fleminger S, Ponsford J. Long term outcome after traumatic brain injury. BMJ 2005;331:1419-20, doi:10.1136/bmj.331.7530.1419.
23. Agha A, Phillips J, Thompson CJ. Hypopituitarism following traumatic brain injury (TBI). Br J Neurosurg 2007;21: 210-6, doi: 10.1080/02688690701253331.
24. Dimopoulou I, Tsagarakis S, Kouyialis AT, et al. Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levels. Crit Care Med 2004;32:404-8, doi:10.1097/01.CCM.0000108885.37811.CA.
25. Tanriverdi F, Senyurek H, Unluhizarci K, et al. High risk of hypopituitarism after traumatic brain injury: a prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma. J Clin EndocrinolMetab 2006;91: 2105-11, doi:10.1210/jc.2005-2476.
26. Cohan P, Wang C, McArthur DL, et al. Acute secondary adrenal insufficiency after traumatic brain injury: a prospective study. Crit Care Med 2005;33:2358-66, doi:10.1097/01.CCM.0000181735.51183.A7.
27. Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003;348:727-34, doi:10.1056/NEJMra020529.
28. Edwards P, Arango M, Balica L, et al. Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet 2005;365:1957-9, doi:10.1016/S0140-6736(05)66552-X.
29. Roberts I, Yates D, Sandercock P, et al. Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004;364:1321-8, doi:10.1016/S0140-6736(04)17188-2.
30. SanoFi Diagnostics Pasteur. Access immunoassay system manual of operation. SanoFi Pasteur Diagnostics; 1995.
31. Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288:862-71, doi:10.1001/jama.288.7.862.
32. Marik PE. Critical illness-related corticosteroid insufficiency. Chest 2009;135:181-93, doi:10.1378/chest.08-1149.
33. Annane D, Sebille V, Troche G, et al. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000;283:1038-45, doi:10.1001/jama.283.8.1038.
34. Weant KA, Sasaki-Adams D, Dziedzic K, et al. Acute relative adrenal insufficiency after aneurysmal subarachnoid hemorrhage. Neurosurgery 2008;63:645-50, doi:10.1227/01.NEU.0000325728.S0939.15.
35. Price KA, Allen U, Mandersloot G, et al. Effect of a single dose of etomidate on adrenal function in patients with trauma. Crit Care 2005;9 Suppl 1:P392, doi:10.1186/cc3455.
36. Bernard F, Outtrim J, Menon DK, et al. Incidence of adrenal insufficiency after severe traumatic brain injury varies according to definition used: clinical implications. Br J Anaesth 2006;96:72-6, doi:10.1093/bja/aei277.
37. Hoen S, Asehnoune K, Brailly-Tabard S, et al. Cortisol response to corticotropin stimulation in trauma patients: influence of hemorrhagic shock. Anesthesiology 2002;97:807-13, doi:10.1097/00000542-200210000-00010.
38. McCarney R, Warner J, Iliffe S, et al. The Hawthorne effect: a randomised, controlled trial. BMC Med Res Methodol 2007; 7:30, doi:10.1186/1471-2288-7-30.
39. Himmelseher S, Durieux ME. Revising a dogma: ketamine for patients with neurological injury? Anesth Analg 2005;101: 524-34, doi:10.1213/01.ANE.0000160585.43587.5B.
40. Sehdev RS, Symmons DA, Kindl K. Ketamine for rapid sequence induction in patients with head injury in the emergency department. Emerg Med Australas 2006;18:37-44, doi:10.1111/j.1742-6723.2006.00802.x.
41. Payen JF, Dupuis C, Trouve-Buisson T, et al. Corticosteroid after etomidate in critically ill patients: a randomized controlled trial. Crit Care Med 2012;40:29-35, doi:10.1097/CCM.0b013e31822d7938.
42. Roquilly A, Mahe PJ, Seguin P, et al. Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study. JAMA 2011;305:1201-9, doi:10.1001/jama.2011.360.