Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial

The Lancet

Volumn 374, Issue 9686, 2009, Pages 293-300

  Jabre, Patricia ^a,b,c   Combes, Xavier ^b   Lapostolle, Frederic ^a   Dhaouadi, Mohamed ^d   Ricard Hibon, Agnes ^e   Vivien, Benoit ^f   Bertrand, Lionel ^g   Beltramini, Alexandra ^h   Gamand, Pascale ⁱ   Albizzati, Stephane ^j   Perdrizet, Deborah ^k   Lebail, Gaelle ^l   Chollet Xemard, Charlotte ^b   Maxime, Virginie ^l   Brun Buisson, Christian ^b   Lefrant, Jean Yves ^m   Bollaert, Pierre Edouard ^j   Megarbane, Bruno ⁿ   Ricard, Jean Damien ^o   Anguel, Nadia ^p   Vicaut, Eric ^q   Adnet, Frederic ^a   more..

^a AVICENNE HOSPITAL   (France)

^b HENRI MONDOR HOSPITAL   (France)

^c INSERM   (France)

^d NÎMES UNIVERSITY HOSPITAL   (France)

^e BEAUJON HOSPITAL   (France)

^f HÔPITAL NECKER ENFANTS MALADES   (France)

^g Centre Hospitalier de Montauban   (France)

^h CENTRE HOSPITALIER INTERCOMMUNAL   (France)

ⁱ CENTRE HOSPITALIER DE MEAUX   (France)

^j UNIVERSITY HOSPITAL OF NANCY   (France)

^k CHD de la Roche sur Yon   (France)

^l RAYMOND POINCARÉ HOSPITAL   (France)

^m Hôpital de Nîmes   (France)

ⁿ HÔPITAL LARIBOISIÈRE   (France)

^o HÔPITAL LOUIS MOURIER   (France)

^p BICÊTRE HOSPITAL   (France)

^q HÔPITAL FERNAND WIDAL   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; ETOMIDATE; FENTANYL; HYDROCORTISONE; KETAMINE; LIPURO; MIDAZOLAM; SUFENTANIL; SUXAMETHONIUM; SUXAMETHONIUM IODIDE; UNCLASSIFIED DRUG;

ADRENAL INSUFFICIENCY; ADULT; ARTICLE; BOLUS INJECTION; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOTROPIN TEST; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DRUG MECHANISM; EMERGENCY PATIENT; ENDOTRACHEAL INTUBATION; FEMALE; FRANCE; HUMAN; HYDROCORTISONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEPSIS; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; TREATMENT OUTCOME;

EID: 67651011893     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(09)60949-1     Document Type: Article

References (30)

1. de Jong F.H., Mallios C., Jansen C., Scheck P.A., and Lamberts S.W. Etomidate suppresses adrenocortical function by inhibition of 11 beta-hydroxylation. J Clin Endocrinol Metab 59 (1984) 1143-1147
2. Malerba G., Romano-Girard F., Cravoisy A., et al. Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. Intensive Care Med 31 (2005) 388-392
3. Ledingham I.M., and Watt I. Influence of sedation on mortality in critically ill multiple trauma patients. Lancet 321 (1983) 1270
4. Annane D., Sebille V., Troche G., Raphael J.C., Gajdos P., and Bellissant E. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 283 (2000) 1038-1045
5. de Jong M.F., Beishuizen A., Spijkstra J.J., and Groeneveld A.B. Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock. Crit Care Med 35 (2007) 1896-1903
6. Lipiner-Friedman D., Sprung C.L., Laterre P.F., et al. Adrenal function in sepsis: the retrospective Corticus cohort study. Crit Care Med 35 (2007) 1012-1018
7. den Brinker M., Hokken-Koelega A.C., Hazelzet J.A., de Jong F.H., Hop W.C., and Joosten K.F. One single dose of etomidate negatively influences adrenocortical performance for at least 24 h in children with meningococcal sepsis. Intensive Care Med 34 (2008) 163-168
8. Hildreth A.N., Mejia V.A., Maxwell R.A., Smith P.W., Dart B.W., and Barker D.E. Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study. J Trauma 65 (2008) 573-579
9. Annane D. ICU physicians should abandon the use of etomidate!. Intensive Care Med 31 (2005) 325-326
10. Zed P.J., Abu-Laban R.B., and Harrison D.W. Intubating conditions and hemodynamic effects of etomidate for rapid sequence intubation in the emergency department: an observational cohort study. Acad Emerg Med 13 (2006) 378-383
11. Adnet F., and Lapostolle F. International EMS systems: France. Resuscitation 63 (2004) 7-9
12. Vincent J.L., Moreno R., Takala J., et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22 (1996) 707-710
13. Ferreira F.L., Bota D.P., Bross A., Melot C., and Vincent J.L. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 286 (2001) 1754-1758
14. Moreno R., Vincent J.L., Matos R., et al. The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM. Intensive Care Med 25 (1999) 686-696
15. Marik P.E., Pastores S.M., Annane D., et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 36 (2008) 1937-1949
16. Sprung C.L., Annane D., Keh D., et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 358 (2008) 111-124
17. Adnet F., Borron S.W., Racine S.X., et al. The intubation difficulty scale (IDS): proposal and evaluation of a new score characterizing the complexity of endotracheal intubation. Anesthesiology 87 (1997) 1290-1297
18. Patila T., Kukkonen S., Vento A., Pettila V., and Suojaranta-Ylinen R. Relation of the Sequential Organ Failure Assessment score to morbidity and mortality after cardiac surgery. Ann Thorac Surg 82 (2006) 2072-2078
19. Riche F.C., Boutron C.M., Valleur P., et al. Adrenal response in patients with septic shock of abdominal origin: relationship to survival. Intensive Care Med 33 (2007) 1761-1766
20. Ray D.C., and McKeown D.W. Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. Crit Care 11 (2007) R56
21. Mohammad Z., Afessa B., and Finkielman J.D. The incidence of relative adrenal insufficiency in patients with septic shock after the administration of etomidate. Crit Care 10 (2006) R105
22. Cooper M.S., and Stewart P.M. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 348 (2003) 727-734
23. de Jong M.F., Beishuizen A., Spijkstra J.J., et al. Predicting a low cortisol response to adrenocorticotrophic hormone in the critically ill: a retrospective cohort study. Crit Care 11 (2007) R61
24. Oltmanns K.M., Fehm H.L., and Peters A. Chronic fentanyl application induces adrenocortical insufficiency. J Intern Med 257 (2005) 478-480
25. Verborgh C., De Coster R., D'Haese J., Camu F., and Meert T.F. Effects of chlordiazepoxide on opioid-induced antinociception and respiratory depression in restrained rats. Pharmacol Biochem Behav 59 (1998) 663-670
26. Sivilotti M.L., Filbin M.R., Murray H.E., Slasor P., and Walls R.M. Does the sedative agent facilitate emergency rapid sequence intubation?. Acad Emerg Med 10 (2003) 612-620
27. Sivilotti M.L., and Ducharme J. Randomized, double-blind study on sedatives and hemodynamics during rapid-sequence intubation in the emergency department: The SHRED Study. Ann Emerg Med 31 (1998) 313-324
28. Arts D.G., de Keizer N.F., Vroom M.B., and de Jonge E. Reliability and accuracy of Sequential Organ Failure Assessment (SOFA) scoring. Crit Care Med 33 (2005) 1988-1993
29. Antonelli M., Moreno R., Vincent J.L., et al. Application of SOFA score to trauma patients. Sequential Organ Failure Assessment. Intensive Care Med 25 (1999) 389-394
30. Vincent J.L., de Mendonca A., Cantraine F., et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 26 (1998) 1793-1800