Natural Variation in the Drosophila melanogaster Clock Gene Period Modulates Splicing of Its 3′-Terminal Intron and Mid-Day Siesta

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Low, Kwang Huei ^a   Chen, Wen Feng ^a,b   Yildirim, Evrim ^a   Edery, Isaac ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR CLOCK;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DARKNESS; DNA SEQUENCE; DROSOPHILA MELANOGASTER; ENVIRONMENTAL TEMPERATURE; GENE DELETION; GENE INSERTION; GENOTYPE; HAPLOTYPE; INTRON; LOCOMOTION; NONHUMAN; OSCILLATION; PROTEIN FUNCTION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP WAKING CYCLE; TEMPERATURE ACCLIMATIZATION; TRANSGENIC ORGANISM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOLOGICAL CLOCKS; CELLS, CULTURED; CIRCADIAN RHYTHM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENES, INSECT; HAPLOTYPES; INBREEDING; INTRONS; MALE; PERIOD CIRCADIAN PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA SPLICING; SLEEP; TIME FACTORS;

DROSOPHILA MELANOGASTER;

EID: 84869028981     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049536     Document Type: Article

References (19)

1. Rosato E, Kyriacou CP, (2006) Analysis of locomotor activity rhythms in Drosophila. Nat Protoc 1: 559-568.
2. Collins BH, Rosato E, Kyriacou CP, (2004) Seasonal behavior in Drosophila melanogaster requires the photoreceptors, the circadian clock, and phospholipase C. Proc Natl Acad Sci U S A. 101: 1945-1950.
3. Low KH, Lim C, Ko HW, Edery I, (2008) Natural variation in the splice site strength of a clock gene and species-specific thermal adaptation. Neuron 60: 1054-1067.
4. Majercak J, Chen WF, Edery I, (2004) Splicing of the period gene 3′-terminal intron is regulated by light, circadian clock factors, and phospholipase C. Mol Cell Biol. 24: 3359-3372.
5. Majercak J, Sidote D, Hardin PE, Edery I, (1999) How a circadian clock adapts to seasonal decreases in temperature and day length. Neuron 24: 219-230.
6. Petersen G, Hall JC, Rosbash M, (1988) The period gene of Drosophila carries species-specific behavioral instructions. EMBO J 7: 3939-3947.
7. Sawyer LA, Hennessy JM, Peixoto AA, Rosato E, Parkinson H, et al. (1997) Natural variation in a Drosophila clock gene and temperature compensation. Science 278: 2117-2120.
8. Wheeler DA, Kyriacou CP, Greenacre ML, Yu Q, Rutila JE, et al. (1991) Molecular transfer of a species-specific behavior from Drosophila simulans to Drosophila melanogaster. Science 251: 1082-1085.
9. Verrelli BC, Eanes WF, (2001) Clinal variation for amino acid polymorphisms at the Pgm locus in Drosophila melanogaster. Genetics 157: 1649-1663.
10. Hamblen-Coyle MJ, Wheeler DA, Rutila JE, Rosbash M, Hall JC, (1992) Behavior of period-altered circadian rhythm mutants of Drosophila in light:dark cycles (Diptera: Drosophilidae). J Insect Beh 5: 417-446.
11. Wheeler DA, Hamblen-Coyle MJ, Dushay MS, Hall JC, (1993) Behavior in light-dark cycles of Drosophila mutants that are arrhythmic, blind, or both. J Biol Rhythms 8: 67-94.
12. Tomioka K, Sakamoto M, Harui Y, Matsumoto N, Matsumoto A, (1998) Light and temperature cooperate to regulate the circadian locomotor rhythm of wild type and period mutants of Drosophila melanogaster. J Insect Physiol 44: 587-596.
13. Kim EY, Ko HW, Yu W, Hardin PE, Edery I, (2007) A DOUBLETIME kinase binding domain on the Drosophila PERIOD protein is essential for its hyperphosphorylation, transcriptional repression, and circadian clock function. Mol Cell Biol 27: 5014-5028.
14. Lee C, Bae K, Edery I, (1998) The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex. Neuron 21: 857-867.
15. Padgett RA, (2012) New connections between splicing and human disease. Trends Genet 28: 147-154.
16. Citri Y, Colot HV, Jacquier AC, Yu Q, Hall JC, et al. (1987) A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene. Nature 326: 42-47.
17. Graveley BR, (2000) Sorting out the complexity of SR protein functions. RNA 6: 1197-1211.
18. Vanin S, Bhutani S, Montelli S, Menegazzi P, Green EW, et al. (2012) Unexpected features of Drosophila circadian behavioural rhythms under natural conditions. Nature 484: 371-375.
19. Chiu JC, Low KH, Pike DH, Yildirim E, Edery I (2010) Assaying locomotor activity to study circadian rhythms and sleep parameters in Drosophila. J Vis Exp.