Natural antibody to apoptotic cell membranes inhibits the proinflammatory properties of lupus autoantibody immune complexes

Arthritis and Rheumatism

Volumn 64, Issue 10, 2012, Pages 3388-3398

  Vas, Jaya ^a   Grönwall, Caroline ^a   Marshak Rothstein, Ann ^b   Silverman, Gregg J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; DNA; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 38; RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVATION; CELL MEMBRANE; CHROMATIN; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOFLUORESCENCE MICROSCOPY; INFLAMMATION; MOUSE; MYELOID DENDRITIC CELL; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; APOPTOSIS; AUTOANTIBODIES; CELL MEMBRANE; DENDRITIC CELLS; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE;

EID: 84869018101     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34537     Document Type: Article

References (22)

1. Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of Toll-like receptors in the development of chronic inflammatory disease. Ann Rev Immunol 2007; 25: 419-41. (Pubitemid 46697913)
2. Ronnblom L, Pascual V. The innate immune system in SLE: type I interferons and dendritic cells. Lupus 2008; 17: 394-9. (Pubitemid 351798715)
3. Sokolove J, Zhao X, Chandra PE, Robinson WH. Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fc-receptor. Arthritis Rheum 2011; 63: 53-62.
4. Shaw PX, Goodyear CS, Chang MK, Witztum JL, Silverman GJ. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis- associated neo-antigens and apoptotic cells. J Immunol 2003; 170: 6151-7. (Pubitemid 36682598)
5. Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, et al. Regulation of dendritic cells and macrophages by an antiapoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol 2009; 183: 1346-59.
6. Chen Y, Park YB, Patel E, Silverman GJ. IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J Immunol 2009;182: 6031-43.
7. Ehrenstein MR, Notley CA. The importance of natural IgM: scavenger, protector and regulator. Nat Rev Immunol 2010;10: 778-86.
8. Silverman GJ. Regulatory natural autoantibodies to apoptotic cells: pallbearers and protectors. Arthritis Rheum 2011; 63: 597-602.
9. Silverman GJ, Srikrishnan R, Germar K, Goodyear CS, Andrews KA, Ginzler EM, et al. Genetic imprinting of autoantibody repertoires in systemic lupus erythematosus patients. Clin Exp Immunol 2008; 153: 102-16. (Pubitemid 351809346)
10. Griffin DO, Holodick NE, Rothstein TL. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20-CD27-CD43-CD70- [published erratum appears in J Exp Med 2011;208:67, 409, 871]. J Exp Med 2011;208: 67-80.
11. Su J, Hua X, Concha H, Svenungsson E, Cederholm A, Frostegard J. Natural antibodies against phosphorylcholine as potential protective factors in SLE [published erratum appears in Rheumatology (Oxford) 2008;47:1593]. Rheumatology (Oxford) 2008;47: 1144-50. (Pubitemid 352038217)
12. Gronwall C, Akhter E, Oh C, Burlingame RW, Petri M, Silverman GJ. IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE. Clin Immunol 2012; 142: 390-8.
13. Shaw PX, Horkko S, Chang MK, Curtiss LK, Palinski W, Silverman GJ, et al. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin Invest 2000; 105: 1731-40. (Pubitemid 30421754)
14. Monestier M, Novick KE. Specificities and genetic characteristics of nucleosome-reactive antibodies from autoimmune mice. Mol Immunol 1996; 33: 89-99. (Pubitemid 26079218)
15. Eilat D, Fischel R. Recurrent utilization of genetic elements in V regions of antinucleic acid antibodies from autoimmune mice. J Immunol 1991; 147: 361-8.
16. Vicari AP, Chiodoni C, Vaure C, Ait-Yahia S, Dercamp C, Matsos F, et al. Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody. J Exp Med 2002; 196: 541-9.
17. Boule MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med 2004; 199: 1631-40. (Pubitemid 38821996)
18. Weinshank RL, Luster AD, Ravetch JV. Function and regulation of a murine macrophage-specific IgG Fc receptor, Fc-R-. J Exp Med 1988; 167: 1909-25.
19. Lotze MT, Zeh HJ, Rubartelli A, Sparvero LJ, Amoscato AA, Washburn NR, et al. The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity. Immunol Rev 2007; 220: 60-81. (Pubitemid 350045579)
20. Radic M, Marion T, Monestier M. Nucleosomes are exposed at the cell surface in apoptosis. J Immunol 2004; 172: 6692-700. (Pubitemid 38669105)
21. Kawai T, Akira S. TLR signaling. Semin Immunol 2007; 19: 24-32. (Pubitemid 46498752)
22. Chaturvedi A, Dorward D, Pierce SK. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 2008;28: 799-809.