Structural and kinetic effects on changes in the CO2 binding pocket of human carbonic anhydrase II

Biochemistry

Volumn 51, Issue 45, 2012, Pages 9156-9163

  West, Dayne ^a   Kim, Chae Un ^c   Tu, Chingkuang ^b   Robbins, Arthur H ^a   Gruner, Sol M ^c,d   Silverman, David N ^a,b   McKenna, Robert ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c Department of Obstetrics Gynecology   (United States)

^d Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING POCKETS; CATALYTIC EFFICIENCIES; DISSOCIATION RATES; HUMAN CARBONIC ANHYDRASE II; HYDROPHOBIC RESIDUES; KINETIC EFFECT; ORDERED WATER; SIDE-CHAINS; STERIC CROWDING; STRUCTURAL DATA; TRANSITION STATE; WILD TYPES;

AMINO ACIDS; CARBONIC ANHYDRASE; CATALYSIS; DISSOCIATION; EFFICIENCY; HYDROPHOBICITY; MASS SPECTROMETRY; X RAY CRYSTALLOGRAPHY;

CARBON DIOXIDE;

ALANINE; BICARBONATE; CARBON DIOXIDE; CARBONATE DEHYDRATASE II; ISOLEUCINE; LEUCINE; OXYGEN 18; SOLVENT; VALINE; ZINC;

ARTICLE; BIOTRANSFORMATION; CATALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ESCHERICHIA COLI; HYDRATION; HYDROPHOBICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ALANINE; CARBON DIOXIDE; CARBONIC ANHYDRASE II; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOLEUCINE; KINETICS; LEUCINE; MUTAGENESIS, SITE-DIRECTED; VALINE;

EID: 84869007839     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301155z     Document Type: Article

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