A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions

Human Molecular Genetics

Volumn 21, Issue 23, 2012, Pages 5066-5077

  Diaz, Francisca ^a   Garcia, Sofia ^a   Padgett, Kyle R ^a   Moraes, Carlos T ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE 1; CYTOCHROME C OXIDASE 10; IRON SULFUR PROTEIN; MITOCHONDRIAL PROTEIN; REACTIVE OXYGEN METABOLITE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; BRAIN DAMAGE; BRAIN REGION; CINGULATE GYRUS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME SUBUNIT; GENE DELETION; GENETIC CODE; MITOCHONDRIAL DNA DISORDER; MOUSE; NERVE DEGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PYRIFORM CORTEX; RESPIRATORY CHAIN; SOMATOSENSORY CORTEX; SUDDEN DEATH;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BRAIN; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; FEMALE; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NEURODEGENERATIVE DISEASES; NEURONS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES;

EID: 84869003478     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds350     Document Type: Article

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