Construction of recombinant lactobacilli expressing the core neutralizing epitope (COE) of porcine epidemic diarrhea virus and a fusion protein consisting of COE and Escherichia coli heat-labile enterotoxin B, and comparison of the immune responses by orogastric immunization

Canadian Journal of Microbiology

Volumn 58, Issue 11, 2012, Pages 1258-1267

  Ge, Jun Wei ^a   Liu, Di Qiu ^b   Li, Yi Jing ^a,c  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c NONE   (China)

Author keywords

Core neutralizing epitope; Immunogenicity; lactobacillus; Orogastric administration; Porcine epidemic diarrhea virus

Indexed keywords

CORE NEUTRALIZING EPITOPE; ENTEROTOXIN; ENTEROTOXIN B; EPITOPE; GAMMA INTERFERON; HYBRID PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 4; UNCLASSIFIED DRUG;

BACTERIUM; DIARRHEAL DISEASE; DISEASE CONTROL; EPIDEMIC; IMMUNE RESPONSE; IMMUNIZATION; RECOMBINATION; VACCINATION; VIRUS;

ARTICLE; CONTROLLED STUDY; ELECTROTRANSFORMATION; ESCHERICHIA COLI; IMMUNE RESPONSE; IMMUNIZATION; LACTOBACILLUS CASEI; NONHUMAN; PORCINE EPIDEMIC DIARRHEA VIRUS; PRIORITY JOURNAL;

EID: 84869002719     PISSN: 00084166     EISSN: 14803275     Source Type: Journal    
DOI: 10.1139/w2012-098     Document Type: Article

References (30)

1. Cavanagh, D., Brian, D.A., Brinton, M.A., Enjuanes, L., Holmes, K.V., Horzinek, M.C., et al. 1993. The Coronaviridae now comprises two genera, Coronavirus and Torovirus: report of the Coronaviridae Study Group. Adv. Exp. Med. Biol. 342: 255-257. PMID:8209739.
2. Chang, S.H., Bae, J.L., Kang, T.J., Kim, J., Chung, G.H., Lim, C.W., et al. 2002. Identification of the epitope region capable of inducing neutralizing antibodies against the porcine epidemic diarrhea virus. Mol. Cells, 14(2): 295-299. PMID:12442904.
3. Chasey, D., and Cartwright, S.F. 1978. Virus-like particles associated with porcine epidemic diarrhoea. Res. Vet. Sci. 25(2): 255-256. PMID:103154.
4. Cheun, H.I., Kawamoto, K., Hiramatsu, M., Tamaoki, H., Shirahata, T., Igimi, S., and Makino, S.I. 2004. Protective immunity of SpaA-antigen producing Lactococcus lactis against Erysipelothrix rhusiopathiae infection. J. Appl. Microbiol. 96(6): 1347-1353. doi:10.1111/j.1365-2672.2004.02283.x. PMID:15139928.
5. Duarte, M., and Laude, H. 1994. Sequence of the spike protein of the porcine epidemic diarrhoea virus. J. Gen. Virol. 75(5): 1195-1200. doi:10.1099/0022-1317-75-5-1195. PMID:8176382.
6. Egberink, H.F., Ederveen, J., Callebaut, P., and Horzinek, M.C. 1988. Characterization of the structural proteins of porcine epizootic diarrhea virus, strain CV777. Am. J. Vet. Res. 49(8): 1320-1324. PMID:3140695.
7. Elson, C.O., Ealding, W., and Lefkowitz, J. 1984. A lavage technique allowing repeated measurement of IgA antibody in mouse intestinal secretions. J. Immunol. Methods, 67(1): 101-108. doi:10.1016/ 0022-1759(84)90089-9. PMID:6366063.
8. Friedman, R.S., Frankel, F.R., Xu, Z., and Lieberman, J. 2000. Induction of human immunodeficiency virus (HIV)-specific CD8 T-cell responses by Listeria monocytogenes and a hyperattenuated Listeria strain engineered to express HIV antigens. J. Virol. 74(21): 9987-9993. doi:10.1128/JVI.74.21.9987-9993.2000. PMID:11024127.
9. Fujinaga, Y. 2006. Transport of bacterial toxins into target cells: pathways followed by cholera toxin and botulinum progenitor toxin. J. Biochem. 140(2): 155-160. doi:10.1093/jb/mvj161. PMID:16954533.
10. Ho, P.S., Kwang, J., and Lee, Y.K. 2005. Intragastric administration of Lactobacillus casei expressing transmissible gastroentritis coronavirus spike glycoprotein induced specific antibody production. Vaccine, 23(11): 1335-1342. doi:10.1016/j.vaccine.2004.09.015. PMID:15661381.
11. Hou, X.L., Yu, L.Y., Liu, J., and Wang, G.H. 2007. Surfacedisplayed porcine epidemic diarrhea viral (PEDV) antigens on lactic acid bacteria. Vaccine, 26(1): 24-31. doi:10.1016/j.vaccine. 2007.10.065. PMID:18054413.
12. Huy, N.X., Yang, M.S., and Kim, T.G. 2010. Expression of a cholera toxin B subunit-neutralizing epitope of the porcine epidemic diarrhea virus fusion gene in transgenic lettuce (Lactuca sativa L.). Mol. Biotechnol. 48(3): 201-209. doi:10.1007/s12033-010-9359-1.
13. Kang, T.J., Kim, Y.S., Jang, Y.S., and Yang, M.S. 2005. Expression of the synthetic neutralizing epitope gene of porcine epidemic diarrhea virus in tobacco plants without nicotine. Vaccine, 23 (17-18): 2294-2297. doi:10.1016/j.vaccine.2005.01.027. PMID: 15755614.
14. Kang, T.J., Han, S.C., Yang, M.S., and Jang, Y.S. 2006. Expression of synthetic neutralizing epitope of porcine epidemic diarrhea virus fused with synthetic B subunit of Escherichia coli heat-labile enterotoxin in tobacco plants. Protein Expr. Purif. 46(1): 16-22. doi:10.1016/j.pep.2005.07.026. PMID:16174563.
15. Lee, J.S., Shin, K.S., Pan, J.G., and Kim, C.J. 2000. Surfacedisplayed viral antigens on Salmonella carrier vaccine. Nat. Biotechnol. 18(6): 645-648. doi:10.1038/76494. PMID:10835603.
16. Liu, D., Wang, X., Ge, J., Liu, S., and Li, Y. 2011. Comparison of the immune responses induced by oral immunization of mice with Lactobacillus casei-expressing porcine parvovirus VP2 and VP2 fused to Escherichia coli heat-labile enterotoxin B subunit protein. Comp. Immunol. Microbiol. Infect. Dis. 34(1): 73-81. doi: 10.1016/j.cimid.2010.02.004. PMID:20226529.
17. Liyun, Y., Zhigang, Z., Xilin, H., Hongwei, C., and Guihua, W. 2008. Study on the surface displayed porcine epidemic diarrhea viral (PEDV) S1 on lactic acid bacteria. Journal of Heilongjiang August First Land Reclamation University, 4: 45-47. [In Chinese.]
18. Maassen, C., Laman, J., Heijne den Bak-Glashouwer, M., Tielen, F., van Holten-Neelen, J., Hoogteijling, L., et al. 1999. Instruments for oral disease-intervention strategies: recombinant Lactobacillus casei expressing tetanus toxin fragment C for vaccination or myelin proteins for oral tolerance induction in multiple sclerosis. Vaccine, 17(17): 2117-2128. doi:10.1016/S0264-410X(99)00010-9. PMID: 10367944.
19. Mercenier, A., Muller-Alouf, H., and Grangette, C. 2000. Lactic acid bacteria as live vaccines. Curr. Issues Mol. Biol. 2(1): 17-25. PMID:11464916.
20. Pensaert, M.B., and de Bouck, P. 1978. A new coronavirus-like particle associated with diarrhea in swine. Arch. Virol. 58(3): 243-247. doi:10.1007/BF01317606. PMID:83132.
21. Puranaveja, S., Poolperm, P., Lertwatcharasarakul, P., Kesdaengsakonwut, S., Boonsoongnern, A., Urairong, K., et al. 2009. Chineselike strain of porcine epidemic diarrhea virus, Thailand. Emerg. Infect. Dis. 15(7): 1112-1115. doi:10.3201/eid1507.081256. PMID:19624933.
22. Reveneau, N., Geoffroy, M.C., Locht, C., Chagnaud, P., and Mercenier, A. 2002. Comparison of the immune responses induced by local immunizations with recombinant Lactobacillus plantarum producing tetanus toxin fragment C in different cellular locations. Vaccine, 20(13-14): 1769-1777. doi:10.1016/S0264-410X(02) 00027-0. PMID:11906764.
23. Robinson, K., Chamberlain, L.M., Schofield, K.M., Wells, J.M., and Le Page, R.W. 1997. Oral vaccination of mice against tetanus with recombinant Lactococcus lactis. Nat. Biotechnol. 15(7): 653-657. doi:10.1038/nbt0797-653. PMID:9219268.
24. Shata, M.T., and Hone, D.M. 2001. Vaccination with a Shigella DNA vaccine vector induces antigen-specific CD8+ T cells and antiviral protective immunity. J. Virol. 75(20): 9665-9670. doi:10.1128/ JVI.75.20.9665-9670.2001. PMID:11559798.
25. Shata, M.T., Reitz, M.S., Jr, DeVico, A.L., Lewis, G.K., and Hone, D.M. 2001. Mucosal and systemic HIV-1 Env-specific CD8(+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector. Vaccine, 20(3-4): 623-629. doi: 10.1016/S0264-410X(01)00330-9. PMID:11672930.
26. Song, D., and Park, B. 2012. Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines. Virus Genes J. 44(2): 167-175. doi:10.1007/s11262-012-0713-1.
27. Song, D.S., Oh, J.S., Kang, B.K., Yang, J.S., Moon, H.J., Yoo, H.S., et al. 2007. Oral efficacy of Vero cell attenuated porcine epidemic diarrhea virus DR13 strain. Res. Vet. Sci. 82(1): 134-140. doi: 10.1016/j.rvsc.2006.03.007. PMID:16730762.
28. Turgeon, D.C., Morin, M., Jolette, J., Higgins, R., Marsolais, G., and DiFranco, E. 1980. Coronavirus-like particles associated with diarrhea in baby pigs in Quebec. Can. Vet. J. 21(3): 100-xxiii. PMID:7363267
29. van Ginkel, F.W., Nguyen, H.H., and McGhee, J.R. 2000. Vaccines for mucosal immunity to combat emerging infectious diseases. Emerg. Infect. Dis. 6(2): 123-132. doi:10.3201/eid0602.000204. PMID:10756145.
30. Yeo, S.G., Hernandez, M., Krell, P.J., and Nagy, É. É. 2003. Cloning and sequence analysis of the spike gene of porcine epidemic diarrhea virus Chinju99. Virus Genes, 26(3): 239-246. doi: 10.1023/A:1024443112717. PMID:12876452.