Synthesis and SAR studies of fused oxadiazines as γ-secretase modulators for treatment of Alzheimer's disease

ACS Medicinal Chemistry Letters

Volumn 3, Issue 11, 2012, Pages 931-935

  Huang, Xianhai ^a   Zhou, Wei ^a   Liu, Xiaoxiang ^a   Li, Hongmei ^a   Sun, George ^a   Mandal, Mihirbaran ^a   Vicarel, Monica ^a   Zhu, Xiaohong ^a   Bennett, Chad ^a   McCraken, Troy ^a   Pissarnitski, Dmitri ^a   Zhao, Zhiqiang ^a   Cole, David ^a   Gallo, Gioconda ^a   Zhu, Zhaoning ^a   Palani, Anandan ^a   Aslanian, Robert ^a   Clader, John ^a   Czarniecki, Michael ^a   Greenlee, William ^a   Burnett, Duane ^a   Cohen Williams, Mary ^a   Hyde, Lynn ^a   Song, Lixin ^a   Zhang, Lili ^a   Chu, Inhou ^a   Buevich, Alexei ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

secreatase modulator; Alzheimer's disease; amyloid precursor protein; morpholine; Notch processing; oxadiazine

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE INHIBITOR; NOTCH1 RECEPTOR; OXADIAZINE DERIVATIVE; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CONFORMATION; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 84868696562     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300209g     Document Type: Article

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