Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators

Tetrahedron Letters

Volumn 53, Issue 47, 2012, Pages 6451-6455

  Huang, Xianhai ^a   Pissarnitski, Dmitri ^a   Li, Hongmei ^a   Asberom, Theodros ^a   Josien, Hubert ^a   Zhu, Xiaohong ^a   Vicarel, Monica ^a   Zhao, Zhiqiang ^a   Rajagopalan, Murali ^a   Palani, Anandan ^a   Aslanian, Robert ^a   Zhu, Zhaoning ^a   Greenlee, William ^a   Buevich, Alexei ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Alzheimer's disease; Cyclization; Gamma secretase modulator; Heterocycles; Morpholine; Oxadiazoline

Indexed keywords

GAMMA SECRETASE; MORPHOLINE DERIVATIVE; MORPHOLINE OXADIAZOLINE DERIVATIVE; NOOTROPIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS; REDUCTION; STEREOCHEMISTRY;

EID: 84867867460     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2012.09.070     Document Type: Article

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