메뉴 건너뛰기




Volumn 7, Issue 11, 2012, Pages

Induced Tauopathy in a Novel 3D-Culture Model Mediates Neurodegenerative Processes: A Real-Time Study on Biochips

Author keywords

[No Author keywords available]

Indexed keywords

TAU PROTEIN;

EID: 84868687152     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049150     Document Type: Article
Times cited : (36)

References (43)
  • 2
    • 29144508843 scopus 로고    scopus 로고
    • Global prevalence of dementia: a Delphi consensus study
    • Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, et al. (2005) Global prevalence of dementia: a Delphi consensus study. Lancet 366: 2112-2117.
    • (2005) Lancet , vol.366 , pp. 2112-2117
    • Ferri, C.P.1    Prince, M.2    Brayne, C.3    Brodaty, H.4    Fratiglioni, L.5
  • 4
    • 78751644048 scopus 로고    scopus 로고
    • Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease
    • Ittner LM, Gotz J, (2011) Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci 12: 65-72.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 65-72
    • Ittner, L.M.1    Gotz, J.2
  • 5
    • 84856956771 scopus 로고    scopus 로고
    • Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells
    • Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, et al. (2012) Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 482: 216-220.
    • (2012) Nature , vol.482 , pp. 216-220
    • Israel, M.A.1    Yuan, S.H.2    Bardy, C.3    Reyna, S.M.4    Mu, Y.5
  • 6
    • 84859760030 scopus 로고    scopus 로고
    • Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy
    • Mondragon-Rodriguez S, Perry G, Zhu X, Boehm J, (2012) Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy. Int J Alzheimers Dis 2012: 630182.
    • (2012) Int J Alzheimers Dis , vol.2012 , pp. 630182
    • Mondragon-Rodriguez, S.1    Perry, G.2    Zhu, X.3    Boehm, J.4
  • 7
    • 79955748480 scopus 로고    scopus 로고
    • Peering inside Alzheimer's brains
    • Sinha G, (2011) Peering inside Alzheimer's brains. Nat Biotechnol 29: 384-387.
    • (2011) Nat Biotechnol , vol.29 , pp. 384-387
    • Sinha, G.1
  • 8
    • 65649128544 scopus 로고    scopus 로고
    • An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells
    • Jahnke HG, Rothermel A, Sternberger I, Mack TG, Kurz RG, et al. (2009) An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells. Lab Chip 9: 1422-1428.
    • (2009) Lab Chip , vol.9 , pp. 1422-1428
    • Jahnke, H.G.1    Rothermel, A.2    Sternberger, I.3    Mack, T.G.4    Kurz, R.G.5
  • 9
    • 84859707391 scopus 로고    scopus 로고
    • Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates
    • Loffler T, Flunkert S, Taub N, Schofield EL, Ward MA, et al. (2012) Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates. J Mol Neurosci 47: 192-203.
    • (2012) J Mol Neurosci , vol.47 , pp. 192-203
    • Loffler, T.1    Flunkert, S.2    Taub, N.3    Schofield, E.L.4    Ward, M.A.5
  • 10
    • 79251575329 scopus 로고    scopus 로고
    • Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease
    • Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, et al. (2011) Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease. Brain Pathol 21: 189-200.
    • (2011) Brain Pathol , vol.21 , pp. 189-200
    • Bose, A.1    Mouton-Liger, F.2    Paquet, C.3    Mazot, P.4    Vigny, M.5
  • 11
    • 59649109230 scopus 로고    scopus 로고
    • Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
    • Pickl M, Ries CH, (2009) Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab. Oncogene 28: 461-468.
    • (2009) Oncogene , vol.28 , pp. 461-468
    • Pickl, M.1    Ries, C.H.2
  • 13
    • 77954554335 scopus 로고    scopus 로고
    • An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons
    • Agholme L, Lindstrom T, Kagedal K, Marcusson J, Hallbeck M, (2010) An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons. J Alzheimers Dis 20: 1069-1082.
    • (2010) J Alzheimers Dis , vol.20 , pp. 1069-1082
    • Agholme, L.1    Lindstrom, T.2    Kagedal, K.3    Marcusson, J.4    Hallbeck, M.5
  • 15
    • 39649090958 scopus 로고    scopus 로고
    • Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation
    • Hinners I, Hill A, Otto U, Michalsky A, Mack TG, et al. (2008) Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation. Mol Cell Neurosci 37: 559-567.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 559-567
    • Hinners, I.1    Hill, A.2    Otto, U.3    Michalsky, A.4    Mack, T.G.5
  • 16
    • 79960454962 scopus 로고    scopus 로고
    • A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring
    • Krinke D, Jahnke HG, Mack TG, Hirche A, Striggow F, et al. (2010) A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring. Biosens Bioelectron 26: 162-168.
    • (2010) Biosens Bioelectron , vol.26 , pp. 162-168
    • Krinke, D.1    Jahnke, H.G.2    Mack, T.G.3    Hirche, A.4    Striggow, F.5
  • 17
    • 43649088478 scopus 로고    scopus 로고
    • Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction
    • Leuba G, Walzer C, Vernay A, Carnal B, Kraftsik R, et al. (2008) Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction. Neurobiol Dis 30: 408-419.
    • (2008) Neurobiol Dis , vol.30 , pp. 408-419
    • Leuba, G.1    Walzer, C.2    Vernay, A.3    Carnal, B.4    Kraftsik, R.5
  • 18
    • 77958001015 scopus 로고    scopus 로고
    • An okadaic acid-induced model of tauopathy and cognitive deficiency
    • Zhang Z, Simpkins JW, (2010) An okadaic acid-induced model of tauopathy and cognitive deficiency. Brain Res 1359: 233-246.
    • (2010) Brain Res , vol.1359 , pp. 233-246
    • Zhang, Z.1    Simpkins, J.W.2
  • 19
    • 64449085887 scopus 로고    scopus 로고
    • A microelectrode-based sensor for label-free in vitro detection of ischemic effects on cardiomyocytes
    • Krinke D, Jahnke HG, Panke O, Robitzki AA, (2009) A microelectrode-based sensor for label-free in vitro detection of ischemic effects on cardiomyocytes. Biosens Bioelectron 24: 2798-2803.
    • (2009) Biosens Bioelectron , vol.24 , pp. 2798-2803
    • Krinke, D.1    Jahnke, H.G.2    Panke, O.3    Robitzki, A.A.4
  • 20
    • 41549135210 scopus 로고    scopus 로고
    • Microcavity array (MCA)-based biosensor chip for functional drug screening of 3D tissue models
    • Kloss D, Kurz R, Jahnke HG, Fischer M, Rothermel A, et al. (2008) Microcavity array (MCA)-based biosensor chip for functional drug screening of 3D tissue models. Biosens Bioelectron 23: 1473-1480.
    • (2008) Biosens Bioelectron , vol.23 , pp. 1473-1480
    • Kloss, D.1    Kurz, R.2    Jahnke, H.G.3    Fischer, M.4    Rothermel, A.5
  • 21
    • 34547183507 scopus 로고    scopus 로고
    • Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies
    • Luo W, Dou F, Rodina A, Chip S, Kim J, et al. (2007) Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A 104: 9511-9516.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 9511-9516
    • Luo, W.1    Dou, F.2    Rodina, A.3    Chip, S.4    Kim, J.5
  • 22
    • 70349638299 scopus 로고    scopus 로고
    • Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
    • Brunden KR, Trojanowski JQ, Lee VM, (2009) Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nat Rev Drug Discov 8: 783-793.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 783-793
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.M.3
  • 23
    • 33646246733 scopus 로고    scopus 로고
    • HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
    • Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, et al. (2006) HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. FASEB J 20: 753-755.
    • (2006) FASEB J , vol.20 , pp. 753-755
    • Dickey, C.A.1    Dunmore, J.2    Lu, B.3    Wang, J.W.4    Lee, W.C.5
  • 24
    • 77952548786 scopus 로고    scopus 로고
    • Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors
    • Brunden KR, Ballatore C, Crowe A, Smith AB 3rd, Lee VM, et al (2010) Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Exp Neurol 223: 304-310.
    • (2010) Exp Neurol , vol.223 , pp. 304-310
    • Brunden, K.R.1    Ballatore, C.2    Crowe, A.3    Smith 3rd, A.B.4    Lee, V.M.5
  • 25
    • 84864301098 scopus 로고    scopus 로고
    • Hsp90 modulation for the treatment of Alzheimer's disease
    • Zhao H, Michaelis ML, Blagg BS, (2012) Hsp90 modulation for the treatment of Alzheimer's disease. Adv Pharmacol 64: 1-25.
    • (2012) Adv Pharmacol , vol.64 , pp. 1-25
    • Zhao, H.1    Michaelis, M.L.2    Blagg, B.S.3
  • 26
    • 65249128503 scopus 로고    scopus 로고
    • Challenges in the conduct of disease-modifying trials in AD: practical experience from a phase 2 trial of Tau-aggregation inhibitor therapy
    • Wischik C, Staff R, (2009) Challenges in the conduct of disease-modifying trials in AD: practical experience from a phase 2 trial of Tau-aggregation inhibitor therapy. J Nutr Health Aging 13: 367-369.
    • (2009) J Nutr Health Aging , vol.13 , pp. 367-369
    • Wischik, C.1    Staff, R.2
  • 27
    • 0027193145 scopus 로고
    • Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway
    • Jalava A, Akerman K, Heikkila J, (1993) Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway. J Cell Physiol 155: 301-312.
    • (1993) J Cell Physiol , vol.155 , pp. 301-312
    • Jalava, A.1    Akerman, K.2    Heikkila, J.3
  • 28
    • 47549110926 scopus 로고    scopus 로고
    • beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells
    • Mikami M, Goubaeva F, Song JH, Lee HT, Yang J, (2008) beta-Adrenoceptor blockers protect against staurosporine-induced apoptosis in SH-SY5Y neuroblastoma cells. Eur J Pharmacol 589: 14-21.
    • (2008) Eur J Pharmacol , vol.589 , pp. 14-21
    • Mikami, M.1    Goubaeva, F.2    Song, J.H.3    Lee, H.T.4    Yang, J.5
  • 29
    • 58749087320 scopus 로고    scopus 로고
    • Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research
    • Cheung YT, Lau WK, Yu MS, Lai CS, Yeung SC, et al. (2009) Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research. Neurotoxicology 30: 127-135.
    • (2009) Neurotoxicology , vol.30 , pp. 127-135
    • Cheung, Y.T.1    Lau, W.K.2    Yu, M.S.3    Lai, C.S.4    Yeung, S.C.5
  • 30
    • 31044451413 scopus 로고    scopus 로고
    • Artificial design of three-dimensional retina-like tissue from dissociated cells of the mammalian retina by rotation-mediated cell aggregation
    • Rothermel A, Biedermann T, Weigel W, Kurz R, Ruffer M, et al. (2005) Artificial design of three-dimensional retina-like tissue from dissociated cells of the mammalian retina by rotation-mediated cell aggregation. Tissue Eng 11: 1749-1756.
    • (2005) Tissue Eng , vol.11 , pp. 1749-1756
    • Rothermel, A.1    Biedermann, T.2    Weigel, W.3    Kurz, R.4    Ruffer, M.5
  • 31
    • 79955441814 scopus 로고    scopus 로고
    • Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles
    • Guo JL, Lee VM, (2011) Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. J Biol Chem 286: 15317-15331.
    • (2011) J Biol Chem , vol.286 , pp. 15317-15331
    • Guo, J.L.1    Lee, V.M.2
  • 32
    • 57649129018 scopus 로고    scopus 로고
    • Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation
    • Jeganathan S, Hascher A, Chinnathambi S, Biernat J, Mandelkow EM, et al. (2008) Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. J Biol Chem 283: 32066-32076.
    • (2008) J Biol Chem , vol.283 , pp. 32066-32076
    • Jeganathan, S.1    Hascher, A.2    Chinnathambi, S.3    Biernat, J.4    Mandelkow, E.M.5
  • 33
    • 78649732405 scopus 로고    scopus 로고
    • Human stem cell-derived neurons: a system to study human tau function and dysfunction
    • Iovino M, Patani R, Watts C, Chandran S, Spillantini MG, (2010) Human stem cell-derived neurons: a system to study human tau function and dysfunction. PLoS One 5: e13947.
    • (2010) PLoS One , vol.5
    • Iovino, M.1    Patani, R.2    Watts, C.3    Chandran, S.4    Spillantini, M.G.5
  • 34
    • 47849128898 scopus 로고    scopus 로고
    • Inhibition of PHF-like tau hyperphosphorylation in SH-SY5Y cells and rat brain slices by K252a
    • Hubinger G, Geis S, LeCorre S, Muhlbacher S, Gordon S, et al. (2008) Inhibition of PHF-like tau hyperphosphorylation in SH-SY5Y cells and rat brain slices by K252a. J Alzheimers Dis 13: 281-294.
    • (2008) J Alzheimers Dis , vol.13 , pp. 281-294
    • Hubinger, G.1    Geis, S.2    LeCorre, S.3    Muhlbacher, S.4    Gordon, S.5
  • 35
    • 84864615577 scopus 로고    scopus 로고
    • Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies
    • Julien C, Bretteville A, Planel E, (2012) Biochemical isolation of insoluble tau in transgenic mouse models of tauopathies. Methods Mol Biol 849: 473-491.
    • (2012) Methods Mol Biol , vol.849 , pp. 473-491
    • Julien, C.1    Bretteville, A.2    Planel, E.3
  • 36
    • 43049143027 scopus 로고    scopus 로고
    • Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy
    • Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, et al. (2008) Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest 118: 1877-1889.
    • (2008) J Clin Invest , vol.118 , pp. 1877-1889
    • Lim, J.1    Balastik, M.2    Lee, T.H.3    Nakamura, K.4    Liou, Y.C.5
  • 38
    • 58149178486 scopus 로고    scopus 로고
    • 3D cell culture opens new dimensions in cell-based assays
    • Justice BA, Badr NA, Felder RA, (2009) 3D cell culture opens new dimensions in cell-based assays. Drug Discov Today 14: 102-107.
    • (2009) Drug Discov Today , vol.14 , pp. 102-107
    • Justice, B.A.1    Badr, N.A.2    Felder, R.A.3
  • 40
    • 84878818551 scopus 로고    scopus 로고
    • Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures
    • Jahnke HG, Braesigk A, Mack TG, Ponick S, Striggow F, et al. (2011) Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures. Biosens Bioelectron.
    • (2011) Biosens Bioelectron
    • Jahnke, H.G.1    Braesigk, A.2    Mack, T.G.3    Ponick, S.4    Striggow, F.5
  • 41
    • 72949089907 scopus 로고    scopus 로고
    • Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
    • Zhang XM, Cai Y, Xiong K, Cai H, Luo XG, et al. (2009) Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur J Neurosci 30: 2271-2283.
    • (2009) Eur J Neurosci , vol.30 , pp. 2271-2283
    • Zhang, X.M.1    Cai, Y.2    Xiong, K.3    Cai, H.4    Luo, X.G.5
  • 42
    • 77957256216 scopus 로고    scopus 로고
    • Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration
    • Alonso AD, Di Clerico J, Li B, Corbo CP, Alaniz ME, et al. (2010) Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem 285: 30851-30860.
    • (2010) J Biol Chem , vol.285 , pp. 30851-30860
    • Alonso, A.D.1    Di Clerico, J.2    Li, B.3    Corbo, C.P.4    Alaniz, M.E.5
  • 43
    • 78149391828 scopus 로고    scopus 로고
    • Alzheimer disease: caspases first
    • Avila J, (2010) Alzheimer disease: caspases first. Nat Rev Neurol 6: 587-588.
    • (2010) Nat Rev Neurol , vol.6 , pp. 587-588
    • Avila, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.