Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 485-492

  Ribone, Sergio R ^a   Leen, Volker ^b   Madrid, Marcela ^c   Dehaen, Wim ^b   Daelemans, Dirk ^d   Pannecouque, Christophe ^d   Briñón, Margarita C ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^b PITTSBURGH SUPERCOMPUTING CENTER   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

4,6 Diarylpyrimidines; Diarylbenzenes; HIV 1; Molecular modeling; NNRTIs; SAR

Indexed keywords

2,6 DIMETHYL 4 [4 (2,4,6 TRIMETHYLANILINE)PYRIMIDIN 6 YLOXY]BENZONITRILE; 4 [3 (2,4,6 TRIMETHYLANILINE)PHENYL 1 YLAMINO]BENZONITRILE; 4 [3 (2,4,6 TRIMETHYLPHENOXY)PHENYL 1 YLAMINO]BENZONITRILE; 4 [4 (2,4,6 TRIMETHYLPHENOXY)PYRIMIDIN 6 YLAMINO]BENZONITRILE; 4 [4 (4 CYANO 2,6 DIMETHYLPHENOXY)PYRIMIDIN 6 YLAMINO]BENZONITRILE; 6 (2,4,6 TRIMETHYLANILINE) 4 (2,4,6 TRIMETHYLPHENOXY)PYRIMIDINE; ANTIVIRUS AGENT; BENZENE DERIVATIVE; DAPIVIRINE; DELAVIRDINE; ETRAVIRINE; LYSINE; N [3 (2,4,6 TRIMETHYLPHENOXY)PHENYL] N (2,4,6 TRIMETHYLPHENYL)AMINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIMIDINE DERIVATIVE; R 185545; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; WILD TYPE;

ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HIV REVERSE TRANSCRIPTASE; HIV-1; HIV-2; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84868683149     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.036     Document Type: Article

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