Antiepileptic drugs in women with epilepsy during pregnancy

Therapeutic Advances in Drug Safety

Volumn 3, Issue 2, 2012, Pages 71-87

  Gedzelman, Evan ^a   Meador, Kimford J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antiepileptic drugs; congenital malformations; epilepsy; neurodevelopment; pregnancy

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE; CARBAMAZEPINE; ETIRACETAM; FOLIC ACID; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; TOPIRAMATE; VALPROIC ACID;

APGAR SCORE; BIRTH DEFECT; CESAREAN SECTION; CLEFT LIP; CLEFT PALATE; COGNITION; CONGENITAL MALFORMATION; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; EPILEPSY; FIRST TRIMESTER PREGNANCY; GENETIC PREDISPOSITION; HUMAN; INTELLIGENCE QUOTIENT; LOCOMOTION; MATERNAL CARE; NERVE CELL DIFFERENTIATION; NEURAL TUBE DEFECT; PATIENT COUNSELING; PERINATAL DEATH; PREECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; PROTEIN BINDING; PUERPERAL DEPRESSION; REVIEW; RISK REDUCTION; SMALL FOR DATE INFANT; SPINAL DYSRAPHISM; TERATOGENESIS; TERATOGENICITY; VITAMIN SUPPLEMENTATION;

EID: 84868664257     PISSN: 20420986     EISSN: 20420994     Source Type: Journal    
DOI: 10.1177/2042098611433192     Document Type: Review

References (108)

1. Adab N. Jacoby A. Smith D. Chadwick D. (2001) Additional educational needs in children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 70: 15–21.
2. Adab N. Kini U. Vinten J. Ayres J. Baker G. Clayton-Smith J. (2004) The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 75: 1575–1583.
3. Alder J. Fink N. Bitzer J. Hösli I. Holzgreve W. (2007) Depression and anxiety during pregnancy: a risk factor for obstetric, fetal and neonatal outcome? A critical review of the literature. J Matern Fetal Neonatal Med 20: 189–209.
4. Artama M. Auvinen A. Raudaskoski T. Isojärvi I. Isojärvi J. (2005) Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 64: 1874–1878.
5. Asimiadou S. Bittigau P. Felderhoff-Mueser U Manthey D. Sifringer M. Pesditschek S. (2005) Protection with estradiol in developmental models of apoptotic neurodegeneration. Ann Neurol 58: 266–276.
6. Betts T. Fox C. (1999). Proactive preconception counseling for women with epilepsy: is it effective? Seizure 8: 322–327.
7. Bittigau P. Sifringer M. Ikonomidou C. (2003) Antiepileptic drugs and apoptosis in the developing brain. Ann N Y Acad Sci 993: 103-14; discussion 123–4.
8. Bittigau P. Sifringer M. Genz K. Manthey D. Sifringer M. Pesditschek S. (2002) Antiepileptic drugs and apoptotic neurodegeneration in the developing brain. Proc Natl Acad Sci U S A 99: 15089–15094.
9. Borthen I. Eide M. Daltveit A. Gihus N. (2011) Obstetric outcome in women with epilepsy: a hospital-based, retrospective study. BJOG 118: 956–965.
10. Bromley R.L. Mawer G. Clayton-Smith J. Baker G.A. (2008) Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology 71: 1923–1924.
11. Chen Y.H. Chiou H.Y. Lin H.C. Lin H.L. (2009) Affect of seizures during gestation on pregnancy outcomes in women with epilepsy. Arch Neurol 66: 979–984.
12. Craciunescu C.N. Brown E.C. Mar M.H. Albright C.D. Nadeau M.R. Zeisel S.H. (2004) Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain. J Nutr 134: 162–166.
13. Deave T. Heron J. Evans J. Emond A. (2008) The impact of maternal depression in pregnancy on early child development. BJOG 115: 1043–1051.
14. Dolk H. Jentink J. Loane M. Morris J. de Jong-van den Berg L.T. (2008) EUROCAT Antiepileptic Drug Working Group. Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 71: 714–722.
15. Dolovich L.R. Addis A. Vaillancourt J.M. Power J.D. Koren G. Einarson T.R. (1998) Benzodiazepine use in pregnancy and major malformations or oral clefts: meta-analysis of cohort and case-control studies. BMJ 317: 839–843.
16. Eriksson K. Viinikainen K. Mönkkönen A. Îikiä M. Nieminen P. Heinonen S. Kälviäinen R. (2005) Children exposed to valproate in utero – population based evaluation of risks and confounding factors for long-term neurocognitive development. Epilepsy Res 65: 189–200.
17. Eros E. Czeizel A.E. Rockenbauer M. Sorensen H.T. Olsen J. (2002) A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolam and clonazepam treatment during pregnancy. Eur J Obstet Gynaecol Reprod Biol 101: 147–154.
18. Ettinger A. Reed M. Cramer J. (2004) Epilepsy Impact Project Group. Depression and comorbidity in community-based patients with epilepsy or asthma. Neurology 63: 1008–1014.
19. EURAP (2006) Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology 66: 354–360.
20. Farwell J.R. Young J.L. Hirtz D.G. Sulzbacher S.I. Ellenberg J.H. Nelson K.B. (1990) Phenobarbital for febrile seizures – effects on intelligence and on seizure recurrence. N Engl J Med 322: 364–369.
21. Finnell R.H. Chernoff G.F. (1987) Gene-teratogen interactions. An approach to understanding the metabolic basis of birth defects. In: Nau H. Scott W.J. (eds), Pharmacokinetics in Teratogenesis. Boca Raton, FL: CRC Press, pp. 97–109.
22. Gaily E. Kantola-Sorsa E. Granstrom M.L. (1988) Intelligence of children of epileptic mothers. J Pediatr 113: 677–684.
23. Gaily E. Kantola-Sorsa E. Hiilesmaa V. Isoaho M. Matila R. Kotila M. (2004) Normal intelligence in children with prenatal exposure to carbamazepine. Neurology; 62(1):28-32.
24. Galanti M. Newport D.J. Pennell P.B. Titchner D. Newman M. Knight B.T. (2009) Postpartum depression in women with epilepsy: influence of antiepileptic drugs in a prospective study. Epilepsy Behav 16: 426–430.
25. Glier C. Dzietko M. Bittigau P. Jarosz B. Korobowicz E. Ikonomidou C. (2004) Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol 187: 403–409.
26. Hanson J.W. Myrianthopoulos N.C. Harvey M.A. Smith D.W. (1976) Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome. J Pediatr 89: 662–668.
27. Harden C.L. Hopp J. Ting T.Y. Pennell P.B. French J.A. Allen Hauser W. (2009a) Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency. Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 73: 126–132.
28. Harden C.L. Meador K.J. Pennell P.B. Hauser W.A. Gronseth G.S. French J.A. (2009b) Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes. Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 73: 133–141.
29. Harden C.L. Pennell P.B. Koppel B.S. Hovinga C.A. Gidal B. Meador K.J. (2009c) Practice parameter update: management issues for women with epilepsy – focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 73: 142–149.
30. Hay D.F. Pawlby S. Waters C.S. Sharp D. (2008) Antepartum and postpartum exposure to maternal depression: different effects on different adolescent outcomes. J Child Psychol Psychiatry 49: 1079–1088.
31. Hirtz D. Thurman D.J. Gwinn-Hardy K. Mohamed M. Chaudhuri A.R. Zalutsky R. (2007) How common are the “common” neurologic disorders? Neurology 68: 326–337.
32. Hiilesman V. (1996) Effects of maternal seizures on the fetus. In: Tomson T. Gram L. Sillanpää M. Johannesen S. (eds), Epilepsy and Pregnancy. Peterfield, UK and Bristol, PA, USA: Wrightson Biomedical Publishing Ltd, pp. 135–141.
33. Holmes L.B. Mittendorf R. Shen A. Smith C.R. Hernandez-Diaz S. Fetal effects of anticonvulsant polytherapies: different risks from different drug combinations (2011). Arch Neurol 68(10):1275-81. Epub 2011 Jun 13.
34. Holmes L.B. Wyszynski D.F. (2004) North American antiepileptic drug pregnancy registry. Epilepsia 45: 1465.
35. Holmes L.B. Wyszynski D.F. Baldwin E.J. (2006) Increased risk for non-syndromic cleft palate among infants exposed to lamotrigine during pregnancy. Birth Def Res (Part A): Clin Mol Teratol 76: 318.
36. Holmes L.B. Wyszynski D.F. Lieberman E. (2004) The AED (antiepileptic drug) pregnancy registry: a 6-year experience. Arch Neurol 61: 673–678.
37. Holmes L.B. Rosenberger P.B. Harvey E.A. Khoshbin S. Ryan L. (2000) Intelligence and physical features of children of women with epilepsy. Teratology 61(3):196–202.
38. Horwitz S.M. Briggs-Gowan M.J. Storfer-Isser A. Carter A.S. (2007) Prevalence, correlates, and persistence of maternal depression. J Womens Health (Larchmt) 16: 678–691.
39. Hunt S. Craig J. Russell A. Guthrie E. Parsons L. Robertson I. (2006) Levetiracetam in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology 67: 1876–1879.
40. Hunt S. Russell A. Smithson W.H. Parsons L. Robertson I. Waddell R. (2008) UK Epilepsy and Pregnancy Register. Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology 71: 272–276.
41. Hvas C.L. Henriksen T.B. Ostergaard J.R. Dam M. (2000) Epilepsy and pregnancy: effect of antiepileptic drugs and lifestyle on birth weight. Br J Obstet Gynaecol 107: 896–902.
42. Ikonomidou C. Bittigau P. Ishimaru M.J. Wozniak D.F. Koch C. Genz K. (2000) Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 287: 1056–1060.
43. Ikonomidou C. Turski L. (2010) Antiepileptic drugs and brain development. Epilepsy Res 88: 11–22.
44. Jentink J. Bakker M.K. Nijenhuis C.M. Wilffert B. de Jong-van den Berg L.T. (2009) Dose folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid? Pharmacoepidemiol Drug Saf 19: 803–807.
45. Jentink J. Dolk H. Loane M.A. Morris J.K. Wellesley D. Garne E. de Jong-van den Berg L. (2010a) EUROCAT Antiepileptic Study Working Group. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ 341: c6581.
46. Jentink J. Loane M.A. Dolk H. Barisic I. Garne E. Morris J.K. de Jong-van den Berg L.T. (2010b) EUROCAT Antiepileptic Study Working Group. Valproic acid monotherapy in pregnancy and major congenital malformations. N Engl J Med 362: 2185–2193.
47. Kaaja E. Kaaja R. Hiilesmaa V. (2003) Major malformations in offspring of women with epilepsy. Neurology 60: 575–579.
48. Katz I. Kim J. Gale K. Kondratyev A. (2007) Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain. J Pharmacol Exp Ther 322: 494–500.
49. Kelly V.M. Nelson L.M. Chakravarty E.F. (2009) Obstetric outcomes in women with multiple sclerosis and epilepsy. Neurology 73: 1831–1836.
50. Kim J. Kondratyev A. Gale K. (2007) Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy. J Pharmacol Exp Ther 323: 165–173.
51. Koch S. Titze K. Zimmermann R.B. Schröder M. Lehmkuhl U. Rauh H. (1999) Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents. Epilepsia 40: 1237–1243.
52. Laegreid L. Olegard R. Conradi N. Hagberg G. Wahlström J. Abrahamsson L. (1990) Congenital malformations and maternal consumption of benzodiazepines: a case-control study. Dev Med Child Neurol 32: 432–441.
53. Laegreid L. Olegard R. Walstrom J. Conradi N. (1989) Teratogenic effects of benzodiazepine use during pregnancy. J Pediatr 114: 126–131.
54. Loring D.W. Meador K.J. Thompson W.O. (1994) Neurodevelopment effects of phenytoin and carbamazepine. JAMA 272: 850–851.
55. Lösche G. Steinhausen H.C. Koch S. Helge H. (1994) The psychological development of children of epileptic parents. II. The differential impact of intrauterine exposure to anticonvulsant drugs and further influential factors. Acta Paediatr 83: 961–966.
56. Lundgren E.M. Tuvemo T. (2008) Effects of being born small for gestational age on long-term intellectual performance. Best Pract Res Clin Endocrinol Metab 22(3):477–88. Review.
57. Manent J.B. Jorquera I. Mazzucchelli I. Depaulis A. Perucca E. Ben-Ari Y. (2007) Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. Epilepsia 48: 684–693.
58. Manthey D. Asimiadou S. Stefovska V. Kaindl A.M. Fassbender J. Ikonomidou C. (2005) Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain. Exp Neurol 193: 497–503.
59. Mawer G. Briggs M. Baker G.A. Bromley R. Coyle H. Eatock J. (2010) Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study. Seizure 19: 112–119.
60. Meador K.J. Baker G.A. Browning N. Cohen M.J. Clayton-Smith J. Kalayjian L.A. (2011) Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age. Brain 134: 396–404.
61. Meador K.J. Baker G.A. Browning N. Clayton-Smith J. Coombs-Cantrell D.T. Cohen M. for the NEAD Study Group (2009) Fetal antiepileptic drug exposure and cognitive function at age 3. New Eng J Med 360: 1597–1605.
62. Meador K.J. Baker G. Cohen M.J. Gaily E. Westerveld M. (2007) Cognitive/behavioral teratogenetic effects of antiepileptic drugs. Epilepsy Behav 11: 292–302.
63. Meador K.J. Pennell P.B. Harden C.L. Gordon J.C. Tomson T. Kaplan P.W. (2008a) Pregnancy registries in epilepsy: a consensus statement on health outcomes. Neurology 71: 1109–1117.
64. Meador K.J. Reynolds R.W. Crean S. Fahrbach K. Probst C. (2008b) Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res 81: 1–13.
65. Meadow S.R. (1968) Anticonvulsant drugs and congenital abnormalities. Lancet 292: 1296.
66. Medina A.E. Krahe T.E. Coppola D.M. Ramoa A.S. (2003) Neonatal alcohol exposure induces long-lasting impairment of visual cortical plasticity in ferrets. J Neurosci 23: 10002–10012.
67. Mølgaard-Nielsen D. Hviid A. (2011) Newer-generation antiepileptic drugs and the risk of major birth defects. JAMA 305(19):1996–2002.
68. Morrow J.I. Hunt S.J. Russell A.J. Smithson W.H. Parsons L. Robertson I. (2009) Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 80: 506–511.
69. Morrow J. Russell A. Guthrie E. Parsons L. Robertson I. Waddell R. (2006) Malformations risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 77: 193–198.
70. Nadebaum C. Anderson V. Vajda F. Reutens D. Barton S. Wood A. (2011) The Australian Brain and Cognition and Antiepileptic Drugs Study: IQ in school-aged children exposed to sodium valproate and polytherapy. J Int Neuropsychol Soc 17: 133–142.
71. Newport D.J. Levey L.C. Pennell P.B. Ragan K. Stowe Z.N. (2007) Suicidal ideation in pregnancy: assessment and clinical implications. Arch Womens Ment Health 10: 181–187.
72. O–Connor T.G. Heron J. Golding J. Glover V. (2003) Maternal antenatal anxiety and behavioural/emotional problems in children: a test of a programming hypothesis. J Child Psychol Psychiatry 44: 1025–1036.
73. Ogura H. Yasuda M. Nakamura S. Yamashita H. Mikoshiba K. Ohmori H. (2002) Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice. J Neuropathol Exp Neurol 61: 956–967.
74. Palac S. Meador K.J. (2011) Antiepileptic drugs and neurodevelopment: an update. Curr Neurol Neurosci Rep 11 (in press).
75. Pennell P.B. Hovinga C.A. (2008) Antiepileptic drug therapy in pregnancy I: gestation-induced effects on AED pharmacokinetics. Int Rev Neurobiol 83: 227–240.
76. Pennell P.B. Peng L. Newport D.J. Ritchie J.C. Koganti A. Holley D.K. (2008) Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology 70: 2130–2136.
77. Pennell P.B. Newport D.J. Stow Z.N. Helmers S.L. Montgomery J.Q. Henry T.R. (2004) The impact of pregnancy and childbirth on the metabolism of lamotrigine. Neurology 62: 292–295.
78. Petrenaite V. Sabers A. Hansen-Schwartz J. (2005) Individual changes in lamotrigine plasma concentrations during pregnancy. Epilepsy Res 65: 185–188.
79. Petrenaite V. Sabers A. Hansen-Schwartz J. (2009) Seizure deterioration in women treated with oxcarbazepine during pregnancy. Epilepsy Res 84: 245–249.
80. Rasalam A.D. Hailey H. Williams L.H.G. Moore S.J. Turnpenny P.D. Lloyd D.J. (2005) Characteristics of fetal anticonvulsant syndrome associated autistic disorder. Dev Med Child Neurol 47: 551–555.
81. Reinisch J.M. Sanders S.A. Mortensen E.L. Rubin D.B. (1995) In utero exposure to phenobarbital and intelligence deficits in adult men. JAMA 274: 1518–1525.
82. Sabers A. (2009) Influences on seizure activity in pregnant women with epilepsy. Epilepsy Behav 15: 230–234.
83. Sabers A. Petrenaite V. (2009) Seizure frequency in pregnant women treated with lamotrigine monotherapy. Epilepsia 50: 2163–2166.
84. Scolnik D. Nulman I. Rovet J. Gladstone D. Czuchta D. Gardner H.A. (1994) Neurodevelopment of children exposed in utero to phenytoin and carbamazepine monotherapy. JAMA 271: 767–770.
85. Shallcross R. Bromley R.L. Irwin B. Bonnett L.J. Morrow J. Baker G.A. (2011) Liverpool Manchester Neurodevelopment Group; UK Epilepsy and Pregnancy Register. Child development following in utero exposure: levetiracetam vs. sodium valproate. Neurology 76: 383–399.
86. Shapiro S. Hartz S.C. Siskind V. Mitchell A.A. Slone D. Rosenberg L. (1976) Anticonvulsants and parental epilepsy in the development of birth defects. Lancet 1: 272–275.
87. Stefovska V.G. Uckermann O. Czuczwar M. Smitka M. Czuczwar P. Kis J. (2008) Sedative and anticonvulsant drugs suppress postnatal neurogenesis. Ann Neurol 64: 434–445.
88. St Louis E.K. (2009) Monitoring antiepileptic drugs: a level-headed approach. Curr Neuropharmacol 7: 115–119.
89. Tamura T. Goldenberg R.L. Chapman V.R. Johnston K.E. Ramey S.L. Nelson K.G. (2005) Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age. Pediatrics 116: 703–708.
90. Tomson T. Battino D. Bonizzoni E. Craig J. Lindhout D. Sabers A. (2011) Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 7: 609–617.
91. Tran T.A. Leppik I.E. Blesi K. Sathanandan S.T. Remmel R. (2002) Lamotrigine clearance during pregnancy. Neurology 59: 252–255
92. Turner K. Piazzini A. Franza A. Fumarola C. Chifari R. Marconi A.M. (2006) Postpartum depression in women with epilepsy versus women without epilepsy. Epilepsy Behav 9: 293–297.
93. Turner K. Piazzini A. Franza A. Marconi A.M. Canger R. Canevini M.P. (2009) Epilepsy and postpartum depression. Epilepsia 50(Suppl. 1): 24–27.
94. Vajda F. Solinas C. Graham J. Hitchcock A. Eadie M. (2006b) The case for lamotrigine monitoring in pregnancy. J Clin Neurosci 13: 103–104.
95. Vajda F.J. Hitchcock A.A. Graham J. O–Brien T.J. Lander C.M. Eadie M.J. (2010) The teratogenic risk of antiepileptic drug polytherapy. Epilepsia 51: 805–810.
96. Vajda F.J. Hitchcock A.A. Graham J. O–Brien T. Lander C. Eadie M. (2007a) The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies. Aust N Z J Obstet Gynaecol 76: 468–474.
97. Vajda F.J. Hitchcock A. Graham J. Solinas C. O–Brien T.J. Lander C.M. (2006a) Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J Neurol 13: 645–654.
98. Vajda F.J. Lander C.M. Hitchcock A. Graham J. Solinas C. O–Brien T. Eadie M.J. (2007b) Changing Australian prescribing patterns for antiepileptic drugs in pregnancy and their possible consequences. J Clin Neurosci 14: 611–617.
99. Van den Bergh B.R. Mennes M. Oosterlaan J. Stevens V. Stiers P. Marcoen A. (2005) High antenatal maternal anxiety is related to impulsivity during performance on cognitive tasks in 14- and 15-year-olds. Neurosci Biobehav Rev 29: 259–269.
100. Vanoverloop D. Schnell R.R. Harvey E.A. Holmes L.B. (1992) The effects of prenatal exposure to phenytoin and other anticonvulsants on intellectual function at 4 to 8 years of age. Neurotoxicol Teratol 14: 329–335.
101. Veiby G. Daltveit A.K. Engelsen B.A. Gilhus N.E. (2009) Pregnancy, delivery, and outcome for the child in maternal epilepsy. Epilepsia 50: 2130–2139.
102. Viinikainen K. Heinonen S. Eriksson K. Kälviäinen R. (2006) Community-based, prospective, controlled study of obstetric and neonatal outcomes of 179 pregnancies in women with epilepsy. Epilepsia 47: 185–192.
103. Vinten J. Bromley R.L. Taylor J. Adab N. Kini U. Baker G.A. (2009) The behavioral consequences of exposure to antiepileptic drugs in utero. Epilepsy Behav 14: 197–201.
104. Wide K. Hening E. Tomson T. Winbladh B. (2002) Psychomotor development in preschool children exposed to antiepileptic drugs in utero. Acta Paediatr 91: 409–414.
105. Wikner B.N. Stiller C.O. Bergman U. Asker C. Källén B. (2007) Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: neonatal outcome and congenital malformations. Pharmacoepidemiol Drug Saf 16: 1203–1210.
106. Wong W.T. Wong R.O. (2001) Changing specificity of neurotransmitter regulation of rapid dendritic remodeling during synaptogenesis. Nat Neurosci 4: 351–352.
107. Wyszynski D.F. Nambisan M. Surve T. Alsdorf R.M. Smith C.R. Holmes L.B. (2005) Increased rate of major malformations in offspring exposed to valproate during pregnancy. Neurology 64: 961–965.
108. Yerby M.S. (2000) Quality of life, epilepsy advances, and the evolving role of anticonvulsants in women with epilepsy. Neurology 55: S23–S31.