Antiepileptic drugs and neurodevelopment: An update

Current Neurology and Neuroscience Reports

Volumn 11, Issue 4, 2011, Pages 423-427

  Palac, Susan ^a   Meador, Kimford J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiepileptic drugs; Cognition; Epilepsy; Neurodevelopment; Pregnancy

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; GABAPENTIN; HARKOSERIDE; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; PREGABALIN; RUFINAMIDE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

APOPTOSIS; ARTICLE; AUTISM; BRAIN NERVE CELL; CELL PROLIFERATION; COGNITIVE DEFECT; COGNITIVE DEVELOPMENT; COMBINATION CHEMOTHERAPY; EPILEPSY; FEBRILE CONVULSION; HUMAN; INTELLIGENCE QUOTIENT; MONOTHERAPY; NERVE CELL DIFFERENTIATION; NONHUMAN; PATHOPHYSIOLOGY; PRENATAL DRUG EXPOSURE; SYNAPTOGENESIS; ANIMAL; BEHAVIOR; CHEMICALLY INDUCED DISORDER; COGNITION; CONGENITAL MALFORMATION; DRUG EFFECT; FEMALE; NERVE CELL; PHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATION; PRENATAL EXPOSURE; REVIEW;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTICONVULSANTS; BEHAVIOR; COGNITION; COGNITION DISORDERS; EPILEPSY; FEMALE; HUMANS; NEURONS; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 80054827174     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-011-0194-y     Document Type: Article

References (47)

1. Meadow SR. Anticonvulsant drugs and congenital abnormalities. Lancet. 1968;292:1296.
2. Meador K, Reynolds MW, Crean S, et al. Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res. 2008;81:1-13.
3. Hill RM, Verniaud WM, Horning MG, et al. Infants exposed in utero to antiepileptic drugs. Am J Dis Child. 1974;127:645-53.
4. Hanson JW, Myrianthopoulos NC, Harvey MA, et al. Risks to offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome. J Pediatr. 1976;89:662-8.
5. Leavitt AM, Yerby MS, Robinson N, et al. Epilepsy in pregnancy: developmental outcome of offspring at 12 months. Neurology. 1992;42 suppl 5:141-3.
6. Losche G, Steinhausen, Koch S, et al. The psychological development of children of epileptic parents. II. The differential impact of intrauterine exposure to anticonvulsant drugs and further influential factors. Acta Paediatr. 1994;83:961-6. (Pubitemid 24298740)
7. Granstrom ML, Gaily E. Psychomotor development in children of mothers with epilepsy. Neurology. 1992;42:144-8.
8. Reinisch JM, Sanders SA, Mortensen EL, et al. In utero exposure to phenobarbital and intelligence deficits in adult men. JAMA. 1995;274:1518-25.
9. Majewski F, Steger M, Richter B, et al. The teratogenicity of hydantoins and barbiturates in humans, with considerations on the etiology of malformations and cerebral disturbances in the children of epileptic parents. Int J Biol Res Pregnancy. 1981;2:37-45. (Pubitemid 11088621)
10. Wide K, Henning E, Tomson T, et al. Psychomotor development in preschool children exposed to antiepileptic drugs in utero. Acta Paediatr. 2002;91:409-14. (Pubitemid 34478193)
11. Koch S, Titze K, Zimmermann RB, et al. Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents. Epilepsia. 1999;40:1237-43. (Pubitemid 29416392)
12. Nicolai J, Vles JSH, Aldenkamp AP. Neurodevelopmental delay in children exposed to antiepileptic drugs in utero: a critical review directed at structural study-bias. J Neurol Sci. 2008;271:1-14. In this literature review, studies of the cognitive effects of in utero exposure are summarized and critically reviewed. Methodologies that should limit interpretation of study results are highlighted.
13. Adab N, Tudur Smith C, Vinten J, et al. Common antiepileptic drugs in pregnancy in women with epilepsy (Review). Cochrane Database of Systematic Reviews 2010, Issue 1.
14. Meador KJ, Baker GA, Browning N, et al. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. NEJM. 2009;360:1597-605. This is the first prospective study of the longterm cognitive effects of in utero exposure to AEDs. It is also one of the few studies of this subject that analyzes factors that could confound the data.
15. Bromley RL, Mawer G, Love J, et al. Early cognitive development in children born to women with epilepsy: a prospective report. Epilepsia. 2010;51:2058-65.
16. Gaily E, Kantola-Sorsa MA, Hiilesmaa V, et al. Normal intelligence in children with prenatal exposure to carbamazepine. Neurology. 2004;62:28-32. (Pubitemid 38082865)
17. Adab N, Kini U, Vinten J, et al. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry. 2004;75:1575-83. (Pubitemid 39430610)
18. Thomas SV, Ajaykumar B, Sindhu K, et al. Motor and mental development of infants exposed to antiepileptic drugs in utero. Epilepsy Behav. 2008;13:229-36.
19. Titze K, Koch S, Helge H, et al. Prenatal and family risks of children born to mothers with epilepsy: effects on cognitive development. Dev Med Child Neurol. 2008;50:117-22.
20. Vinten J, Bromley RL, Taylor J, et al. The behavioral consequences of exposure to antiepileptic drugs in utero. Epilepsy Behav. 2009;14:197-2001. This study examines long-term behavior consequences of in utero exposure to AEDs. The cognitive tools used are scales that evaluate life skills and parental stress.
21. Dean JCS, Hailey H, Moore SJ, et al. Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth. J Med Genet. 2002;39:251-9. (Pubitemid 34496801)
22. Viinikainen K, Eriksson K, Monkkonen A, et al. The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children. Epilepsy Behav. 2006;9:636-40. (Pubitemid 44815279)
23. Rasalam AD, Hailey H, Williams JHG, et al. Characteristics of fetal anticonvulsant syndrome associated autistic disorder. Dev Med Child Neurol. 2005;47:551-5. (Pubitemid 41131614)
24. Bromley RL, Mawer G, Clayton-Smith J, et al. Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology. 2008;71:1923-4.
25. Stefovska VG, Uckermann O, Czuczwar M, et al. Sedative and anticonvulsant drugs suppress postnatal neurogenesis. Ann Neurol. 2008;64:434-45.
26. Manent JB, Jorquera I, Mazzucchelli I, et al. Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. Epilepsia. 2007;48:684-93. (Pubitemid 46587611)
27. Ogura H, Yasuda M, Nakamura S, et al. Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice. J Neuropathol Exp Neurol. 2002;61:956-67. (Pubitemid 35278717)
28. Wong WT, Wong RO. Changing specificity of neurotransmitter regulation of rapid dendritic remodeling during synaptogenesis. Nat Neurosci. 2001;4:351-2. (Pubitemid 32260107)
29. Bittagau P, Sifringer M, Ikonomidou C. Antiepileptic drugs and apoptosis in the developing brain. Ann NY Acad Sci. 2003;993:103-14. (Pubitemid 36808438)
30. Katz I, Kim J, Gale KN, et al. Effects of lamotrigine alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain. J Pharmacol Exp Ther. 2007;322:494-500. (Pubitemid 47105802)
31. Kim J, Kondratyev A, Gale K. Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy vs polytherapy. J Pharmacol Exp Ther. 2007;323:165-73. (Pubitemid 47443273)
32. Farwell JR, Lee YJ, Hirtz DG, et al. Phenobarbital for febrile seizures-effects on intelligence and on seizure recurrence. NEJM. 1990;322:364-9. (Pubitemid 20042741)
33. Vining EPG, Mellits ED, Dorsen MM, et al. Psychologic and behavioral effects of antiepileptic drugs in children: a doubleblind comparison between phenobarbital and valproic acid. Pediatrics. 1987;80:165-74. (Pubitemid 17126796)
34. Calandre EP, Dominguez-Granados R, Gomez-Rubio M, et al. Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children. Acta Neurol Scand. 1990;81:504-6. (Pubitemid 20220557)
35. Stores G, Hart J. Reading skills of children with generalized or focal epilepsy attending ordinary school. Dev Med Child Neurol. 1976;18:705-16. (Pubitemid 8002316)
36. Forsythe I, Butler R, Berg I, et al. Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. Dev Med Child Neurol. 1991;33:524-43.
37. Aman WG, Werry JS, Paxton JW, et al. Effects of carbamazepine on psychomotor performance in children as a function of dose, concentration, seizure type, and time of medication. Epilepsia. 1990;31:51-60. (Pubitemid 20061087)
38. Bailet LL, Turk WR. The impact of childhood epilepsy on neurocognitive and behavioral performance. Epilepsia. 2000;41:426-31. (Pubitemid 30196608)
39. Donati F, Gobbi G, Campistol J, et al. The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures. Seizure. 2007;16:670-9. (Pubitemid 350027187)
40. Pressler RM, Binnie CD, Coleshill SG, et al. Effect of lamotrigine on cognition in children with epilepsy. Neurology. 2006;66:1495-9. (Pubitemid 43958542)
41. Mandelbaum DE, Bunch M, Kugler SL, et al. Efficacy of levetiracetam at 12 months in children classified by seizure type, cognitive status, and previous anticonvulsant drug us. J Child Neurol. 2005;20:590-4. (Pubitemid 41245802)
42. Levisohn PM, Mintz M, Hunter SJ, et al. Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized, double-blind, placebo-controlled, noninferiority trial. Epilepsia. 2009;50:2377-89.
43. Kang H-C, Eun B-L, Lee CW, et al. The effects of cognitive function and behavioral problems of topiramate compared to carbamazepine as monotherapy for children with Benign Rolandic Epilepsy. Epilepsia. 2007;48:1716-23. (Pubitemid 47352877)
44. Coppola G, Verrotti A, Resicato G, et al. Topiramate in children and adolescents with epilepsy and mental retardation: a prospective study on behavior and cognitive effects. Epilepsy Behav. 2008;12:253-6.
45. Aarsen FK, van den Akker ELT, Drop SLS, et al. Effect of topiramate on cognition in obese children. Neurology. 2006;67:1307-8. (Pubitemid 44563855)
46. Sulzbacher S, Farwell JR, Temkin N, et al. Late cognitive effects of early treatment with phenobarbital. Clin Pediatr. 1999;38:387-95.
47. Vazquez B, Gibson P, Kustra R. Epilepsy and women's health issues: unmet needs-survey results from women with epilepsy. Epilepsy Behav. 2007;10:163-9. (Pubitemid 46132164)