Effects of retrograde gene transfer of brain-derived neurotrophic factor in the rostral spinal cord of a compression model in rat

Molecular Biology Reports

Volumn 39, Issue 8, 2012, Pages 8045-8051

  Zhao, Tengfei ^a   Li, Yan ^b   Dai, Xuesong ^a,b   Wang, Junbo ^c   Qi, Yiying ^b   Wang, Jianwei ^b   Xu, Kan ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c ZHEJIANG UNIVERSITY CITY COLLEGE   (China)

Author keywords

Adenovirus mediated BDNF; Retrograde gene transfer; Rostral spinal cord; Spinal cord injury

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; SPINAL CORD; SPINAL CORD INJURY; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; ANIMAL; DISEASE MODEL; GENE TRANSFER; GENE VECTOR; GENETICS; METABOLISM; MOTOR ACTIVITY; REPORTER GENE; SPINAL CORD COMPRESSION; SPRAGUE DAWLEY RAT;

ADENOVIRIDAE; ANIMALIA; RATTUS;

ADENOVIRIDAE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; FEMALE; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD COMPRESSION;

EID: 84868657619     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1651-7     Document Type: Article

References (31)

1. Profyris C, Cheema SS, Zang D, Azari MF, Boyle K, Petratos S (2004) Degenerative and regenerative mechanisms governing spinal cord injury. Neurobiol Dis 15:415-436
2. Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR (2004) Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J 4:451-464
3. Zhao T, Qi Y, Li Y, Xu K (2011) PI3 kinase regulation of neural regeneration and muscle hypertrophy after spinal cord injury. Mol Biol Rep. doi: 10.1007/s11033-011-1127-1
4. Cai D, Shen Y, De Bellard M, Tang S, Filbin MT (1999) Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron 22:89-101
5. Song G, Cechvala C, Resnick DK, Dempsey RJ, Rao VL (2001) GeneChip analysis after acute spinal cord injury in rat. J Neurochem 79:804-815
6. Zhou L, Shine HD (2003) Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury. J Neurosci Res 74:221-226
7. Namiki J, Kojima A, Tator CH (2000) Effect of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 on functional recovery and regeneration after spinal cord injury in adult rats. J Neurotrauma 17:1219-1231
8. Hiebert GW, Khodarahmi K, McGraw J, Steeves JD, Tetzlaff W (2002) Brain-derived neurotrophic factor applied to the motor cortex promotes sprouting of corticospinal fibers but not regeneration into a peripheral nerve transplant. J Neurosci Res 69:160-168
9. Vavrek R, Girgis J, Tetzlaff W, Hiebert GW, Fouad K (2006) BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain 129:1534-1545
10. Bareyre FM, Kerschensteiner M, Raineteau O, Mettenleiter TC, Weinmann O, Schwab ME (2004) The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci 7:269-277
11. Novikova LN, Novikov LN, Kellerth JO (2000) Survival effects of BDNF and NT-3 on axotomized rubrospinal neurons depend on the temporal pattern of neurotrophin administration. Eur J Neurosci 12:776-780
12. Kishino A, Ishige Y, Tatsuno T, Nakayama C, Noguchi H (1997) BDNF prevents and reverses adult rat motor neuron degeneration and induces axonal outgrowth. Exp Neurol 144:273-286
13. Emborg ME, Kordower JH (2000) Delivery of therapeutic molecules into the CNS. Prog Brain Res 128:323-332
14. Xu K, Uchida K, Nakajima H, Kobayashi S, Baba H (2006) Targeted retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene prevents loss of mouse (twy/twy) anterior horn neurons in vivo sustaining mechanical compression. Spine (Phila Pa 1976) 31:1867-1874
15. Kwon BK, Liu J, Lam C, Plunet W, Oschipok LW, Hauswirth W, et al. (2007) Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury. Spine (Phila Pa 1976) 32:1164-1173
16. Alto LT, Havton LA, Conner JM, Hollis Ii ER, Blesch A, Tuszynski MH (2009) Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nat Neurosci 12:1106-1113
17. Carmel JB, Galante A, Soteropoulos P, Tolias P, Recce M, Young W, et al. (2001) Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss. Physiol Genomics 7:201-213
18. Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI (2003) Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Ann Neurol 53:454-468
19. Nakajima H, Uchida K, Kobayashi S, Kokubo Y, Yayama T, Sato R, et al. (2005) Targeted retrograde gene delivery into the injured cervical spinal cord using recombinant adenovirus vector. Neurosci Lett 385:30-35
20. Nakajima H, Uchida K, Yayama T, Kobayashi S, Guerrero AR, Furukawa S, et al. (2010) Targeted retrograde gene delivery of brain-derived neurotrophic factor suppresses apoptosis of neurons and oligodendroglia after spinal cord injury in rats. Spine (Phila Pa 1976) 35:497-504
21. Conner JM, Lauterborn JC, Yan Q, Gall CM, Varon S (1997) Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J Neurosci 17:2295-2313
22. Widenfalk J, Lundstromer K, Jubran M, Brene S, Olson L (2001) Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J Neurosci 21:3457-3475
23. Ikeda O, Murakami M, Ino H, Yamazaki M, Nemoto T, Koda M, et al. (2001) Acute up-regulation of brain-derived neurotrophic factor expression resulting from experimentally induced injury in the rat spinal cord. Acta Neuropathol 102:239-245
24. Nakamura M, Bregman BS (2001) Differences in neurotrophic factor gene expression profiles between neonate and adult rat spinal cord after injury. Exp Neurol 169:407-415
25. Gulino R, Lombardo SA, Casabona A, Leanza G, Perciavalle V (2004) Levels of brain-derived neurotrophic factor and neurotrophin-4 in lumbar motoneurons after low-thoracic spinal cord hemisection. Brain Res 1013:174-181
26. Qin DX, Zou XL, Luo W, Zhang W, Zhang HT, Li XL, et al. (2006) Expression of some neurotrophins in the spinal motoneurons after cord hemisection in adult rats. Neurosci Lett 410:222-227
27. Hajebrahimi Z, Mowla SJ, Movahedin M, Tavallaei M (2008) Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion. Neurosci Lett 441:261-266
28. Kasahara K, Nakagawa T, Kubota T (2006) Neuronal loss and expression of neurotrophic factors in a model of rat chronic compressive spinal cord injury. Spine (Phila Pa 1976) 31:2059-2066
29. Gerin CG, Madueke IC, Perkins T, Hill S, Smith K, Haley B, et al. (2011) Combination strategies for repair, plasticity and, regeneration using regulation of gene expression during the chronic phase after spinal cord injury. Synapse 65:1255-1281
30. Blesch A (2004) Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer. Methods 33:164-172
31. Hendriks WT, Ruitenberg MJ, Blits B, Boer GJ, Verhaagen J (2004) Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. Prog Brain Res 146:451-476