Detection of microdroplet size and speed using capacitive sensors

Sensors and Actuators, A: Physical

Volumn 171, Issue 2, 2011, Pages 55-62

  Elbuken, Caglar ^a   Glawdel, Tomasz ^a   Chan, Danny ^a   Ren, Carolyn L ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Capacitive sensor; Coplanar electrodes; Microdroplet detection; Microfluidics; Two phase flow

Indexed keywords

ANALYTICAL MODEL; CAPACITANCE SENSORS; CAPACITIVE SENSOR; CO-PLANAR ELECTRODES; CROSS CONTAMINATION; DETECTION SIGNAL; DROPLET-BASED MICROFLUIDICS; EXPERIMENTAL OPTIMIZATION; FINGER DESIGN; INTERDIGITAL; LABVIEW; MICRO DROPLETS; MICRO-FLUIDIC DEVICES; MICROFLUIDIC CHANNEL; PASSIVATION LAYER; SENSING AREAS; SENSING ELECTRODE; SENSOR GEOMETRIES; SENSOR SELECTION; T JUNCTIONS;

CAPACITANCE; ELECTRODES; FLUIDIC DEVICES; MATHEMATICAL MODELS; MICROFLUIDICS; MULTIPHASE FLOW; PASSIVATION; SENSORS;

DROPS;

EID: 80055036787     PISSN: 09244247     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sna.2011.07.007     Document Type: Article

References (37)

1. J.Q. Boedicker, L. Li, T.R. Kline, and R.F. Ismagilov Detecting bacteria and determining their susceptibility to antibiotics by stochastic confinement in nanoliter droplets using plug-based microfluidics Lab Chip 8 2008 1265 1272
2. E. Brouzes, M. Medkova, N. Savenelli, D. Marran, M. Twardowski, J.B. Hutchison, J.M. Rothberg, D.R. Link, N. Perrimon, and M.L. Samuels Droplet microfluidic technology for single-cell high-throughput screening Proc. Natl. Acad. Sci. U. S. A. 106 2009 14195 14200
3. J. Clausell-Tormos, D. Lieber, J.C. Baret, A. El-Harrak, O.J. Miller, L. Frenz, J. Blouwolff, K.J. Humphry, S. Koster, H. Duan, C. Holtze, D.A. Weitz, A.D. Griffiths, and C.A. Merten Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms Chem. Biol. 15 2008 427 437
4. P.M. Gunther, F. Moller, T. Henkel, J.M. Kohler, and G.A. Gross Formation of monomeric and novolak azo dyes in nanofluid segments by use of a double injector chip reactor Chem. Eng. Technol. 28 2005 520 527
5. D.K. Hwang, D. Dendukuri, and P.S. Doyle Microfluidic-based synthesis of non-spherical magnetic hydrogel microparticles Lab Chip 8 2008 1640 1647
6. I. Shestopalov, J.D. Tice, and R.F. Ismagilov Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system Lab Chip 4 2004 316 321
7. H. Song, D.L. Chen, and R.F. Ismagilov Reactions in droplet in microfluidic channels Angew. Chem. 45 2006 7336 7356
8. M.J. Fuerstman, A. Lai, M.E. Thurlow, S.S. Shevkoplyas, H.A. Stone, and G.M. Whitesides The pressure drop along rectangular microchannels containing bubbles Lab Chip 7 2007 1479 1489
9. O. Cybulski, and P. Garstecki Dynamic memory in a microfluidic system of droplets traveling through a simple network of microchannels Lab Chip 10 2010 484 493
10. W. Engl, M. Roche, A. Colin, P. Panizza, and A. Ajdari Droplet traffic at a simple junction at low capillary numbers Phys. Rev. Lett. 95 2005 4
11. M.J. Fuerstman, P. Garstecki, and G.M. Whitesides Coding/decoding and reversibility of droplet trains in microfluidic networks Science 315 2007 828 832
12. M. Schindler, and A. Ajdari Droplet traffic in microfluidic networks: a simple model for understanding and designing Phys. Rev. Lett. 100 2008 044501 044504
13. D.A. Sessoms, M. Belloul, W. Engl, M. Roche, L. Courbin, and P. Panizza Droplet motion in microfluidic networks: hydrodynamic interactions and pressure-drop measurements Phys. Rev. E 80 2009 10
14. D.N. Adamson, D. Mustafi, J.X.J. Zhang, B. Zheng, and R.F. Ismagilov Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices Lab Chip 6 2006 1178 1186
15. N.T. Nguyen, S. Lassemono, and F.A. Chollet Optical detection for droplet size control in microfluidic droplet-based analysis systems Sens. Actuators B: Chem. 117 2006 431 436
16. A.H. Tkaczyk, E.R. Tkaczyk, T.B. Norris, and S. Takayama Microfluidic droplet consistency monitoring and encapsulated cell detection via laser excitation J. Mech. Med. Biol. 11 2011 1 14
17. S. Gawad, L. Schild, and P. Renaud Micromachined impedance spectroscopy flow cytometer for cell analysis and particle sizing Lab Chip 1 2001 76 82
18. K. Cheung, S. Gawad, and P. Renaud Impedance spectroscopy flow cytometry: on-chip label-free cell differentiation Cytometry A 65A 2005 124 132
19. D. Holmes, J.K. She, P.L. Roach, and H. Morgan Bead-based immunoassays using a micro-chip flow cytometer Lab Chip 7 2007 1048 1056
20. M.C. Cole, and P.J.A. Kenis Multiplexed electrical sensor arrays in microfluidic networks Sens. Actuator B: Chem. 136 2009 350 358
21. C.X. Luo, X.J. Yang, O. Fu, M.H. Sun, Q. Ouyang, Y. Chen, and H. Ji Picoliter-volume aqueous droplets in oil: electrochemical detection and east electroporation Electrophoresis 27 2006 1977 1983
22. N. Srivastava, and M.A. Burns Electronic drop sensing in microfluidic devices: automated operation of a nanoliter viscometer Lab Chip 6 2006 744 751
23. F. Wang, and M.A. Burns Multiphase bioreaction microsystem with automated on-chip droplet operation Lab Chip 10 2010 1308 1315
24. J.Z. Chen, A.A. Darhuber, S.M. Troian, and S. Wagner Capacitive sensing of droplets for microfluidic devices based on thermocapillary actuation Lab Chip 4 2004 473 480
25. E. Ghafar-Zadeh, M. Sawan, and D. Therriault A 0.18-μm CMOS capacitive sensor lab-on-chip Sens. Actuator A: Phys. 141 2008 454 462
26. J. Gong, and C.J. Kim All-electronic droplet generation on-chip with real-time feedback control for EWOD digital microfluidics Lab Chip 8 2008 898 906
27. X.Z. Niu, M.Y. Zhang, S.L. Peng, W.J. Wen, and P. Sheng Real-time detection, control, and sorting of microfluidic droplets Biomicrofluidics 1 2007 12
28. H. Ren, R.B. Fair, and M.G. Pollack Automated on-chip droplet dispensing with volume control by electro-wetting actuation and capacitance metering Sens. Actuators B: Chem. 98 2004 319 327
29. S. Murali, X.G. Xia, A.V. Jagtiani, J. Carletta, and J. Zhe Capacitive Coulter counting: detection of metal wear particles in lubricant using a microfluidic device Smart Mater. Struct. 18 2009 6
30. L.L. Sohn, O.A. Saleh, G.R. Facer, A.J. Beavis, R.S. Allan, and D.A. Notterman Capacitance cytometry: measuring biological cells one by one Proc. Natl. Acad. Sci. U. S. A. 97 2000 10687 10690
31. A.V. Mamishev, K. Sundara-Rajan, F. Yang, Y.Q. Du, and M. Zahn Interdigital sensors and transducers Proc. IEEE 92 2004 808 845
32. J.C. McDonald, D.C. Duffy, J.R. Anderson, D.T. Chiu, H. Wu, O.J. Schueller, and G.M. Whitesides Fabrication of microfluidic systems in poly(dimethylsiloxane) Electrophoresis 21 2000 27 40
33. R.F. Samy Soft lithography for applications in microfluidic thermometry, isoelectric focusing, and micromixers Mechanical Engineering 2008 University of Waterloo Waterloo pp. 192
34. P. Garstecki, M.J. Fuerstman, H.A. Stone, and G.M. Whitesides Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up Lab Chip 6 2006 437 446
35. Analog Devices AD7746: 24-bit, 2 Channel Capacitance to Digital Converter, in, 2010.
36. G.A. Ferrier, A.N. Hladio, D.J. Thomson, G.E. Bridges, M. Hedayatipoor, S. Olson, and M.R. Freeman Microfluidic electromanipulation with capacitive detection for the mechanical analysis of cells Biomicrofluidics 2 2008 44102
37. Microchip AN1102 - Layout and physical design guidelines for capacitive sensing, in, 2007.