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Volumn 3, Issue 3, 2012, Pages 113-121

Boceprevir in chronic hepatitis C infection: A perspective review

Author keywords

Boceprevir; Cost effectiveness; Efficacy; Genotype 1 infection; Hepatitis C virus; Peginterferon; Ribavirin

Indexed keywords

AMIODARONE; BEPRIDIL; BOCEPREVIR; BUPRENORPHINE; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DIHYDROERGOTAMINE; ERGOTAMINE; FLECAINIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; METHADONE; METHYLERGOMETRINE; MIDAZOLAM; ORAL CONTRACEPTIVE AGENT; PEGINTERFERON ALPHA2B; PIMOZIDE; PLACEBO; PROPAFENONE; QUINIDINE; RIBAVIRIN; RIFAMPICIN; VIRUS RNA;

EID: 84868649787     PISSN: 20406223     EISSN: 20406231     Source Type: Journal    
DOI: 10.1177/2040622312441496     Document Type: Review
Times cited : (15)

References (36)
  • 1
    • 84855833690 scopus 로고    scopus 로고
    • Impact of erythropoietin on sustained virological response to peginterferon and ribavirin therapy for HCV infection: a systematic review and meta-analysis
    • Alavian S.M. Tabatabaei S.V. Behnava B. (2012) Impact of erythropoietin on sustained virological response to peginterferon and ribavirin therapy for HCV infection: a systematic review and meta-analysis. J Viral Hepat 19: 88–93.
    • (2012) J Viral Hepat , vol.19 , pp. 88-93
    • Alavian, S.M.1    Tabatabaei, S.V.2    Behnava, B.3
  • 2
    • 84993791691 scopus 로고    scopus 로고
    • PROBE Study Group
    • and the Pre-treatment factors predicting sustained virological response in treatment-naive HCV genotype 1 patients participating in a large, practice-based nationwide observational study
    • Alberti A. Ascione A. Colombo M. Craxì A. Piccinino F. Rizzetto M. Sarracino M. and the PROBE Study Group (2007) Pre-treatment factors predicting sustained virological response in treatment-naive HCV genotype 1 patients participating in a large, practice-based nationwide observational study. J Hepatol 46:(Suppl. 1):S215.
    • (2007) J Hepatol , vol.46 , pp. S215
    • Alberti, A.1    Ascione, A.2    Colombo, M.3    Craxì, A.4    Piccinino, F.5    Rizzetto, M.6    Sarracino, M.7
  • 3
    • 23444455619 scopus 로고    scopus 로고
    • Experts’ opinions on the role of liver biopsy in HCV infection: a Delphi survey by the Italian Association of Hospital Gastroenterologists (A.I.G.O.)
    • Almasio P.L. Niero M. Angioli D. Ascione A. Gullini S. Minoli G. et al. (2005) Experts’ opinions on the role of liver biopsy in HCV infection: a Delphi survey by the Italian Association of Hospital Gastroenterologists (A.I.G.O.). J Hepatol 43: 381–387.
    • (2005) J Hepatol , vol.43 , pp. 381-387
    • Almasio, P.L.1    Niero, M.2    Angioli, D.3    Ascione, A.4    Gullini, S.5    Minoli, G.6
  • 4
    • 72249094116 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin is more effective than peginterferon alfa-2b plus ribavirin for treating chronic hepatitis C virus infection
    • Ascione A. de Luca M. Tartaglione M.T. Lampasi F. Di Costanzo G.G. Lanza A.G. et al. (2010) Peginterferon alfa-2a plus ribavirin is more effective than peginterferon alfa-2b plus ribavirin for treating chronic hepatitis C virus infection. Gastroenterology 138: 116–122.
    • (2010) Gastroenterology , vol.138 , pp. 116-122
    • Ascione, A.1    de Luca, M.2    Tartaglione, M.T.3    Lampasi, F.4    Di Costanzo, G.G.5    Lanza, A.G.6
  • 5
    • 84861188886 scopus 로고    scopus 로고
    • Predictors of sustained virologic response (SVR) among poor interferon (IFN) responders when boceprevir (BOC) is added to peginterferon alfa-2b/ribavirin (PR)
    • Bacon B.R. Bruno S. Schiff E.R. Kwo P.Y. Buti M. Pedicone L. (2011) Predictors of sustained virologic response (SVR) among poor interferon (IFN) responders when boceprevir (BOC) is added to peginterferon alfa-2b/ribavirin (PR). Hepatology 54 (Suppl.):376A.
    • (2011) Hepatology , vol.54 , pp. 376A
    • Bacon, B.R.1    Bruno, S.2    Schiff, E.R.3    Kwo, P.Y.4    Buti, M.5    Pedicone, L.6
  • 7
    • 84867688570 scopus 로고    scopus 로고
    • Analysis of resistance-associated amino acid variants (RAVs) in non-SVR patients enrolled in a retrospective long-term follow-up analysis of boceprevir phase 3 clinical studies
    • Barnard R.J. Zeuzem S. Vierling J.M. Sulkowski M.S. Manns M.P. Long J. et al. (2011) Analysis of resistance-associated amino acid variants (RAVs) in non-SVR patients enrolled in a retrospective long-term follow-up analysis of boceprevir phase 3 clinical studies. Hepatology 54 (Suppl.): 440A.
    • (2011) Hepatology , vol.54 , pp. 440A
    • Barnard, R.J.1    Zeuzem, S.2    Vierling, J.M.3    Sulkowski, M.S.4    Manns, M.P.5    Long, J.6
  • 8
    • 79952907374 scopus 로고    scopus 로고
    • Boceprevir
    • Boceprevir (2010) Drugs 10: 203–210.
    • (2010) Drugs , vol.10 , pp. 203-210
  • 9
    • 79955900300 scopus 로고    scopus 로고
    • Ribavirin for chronic hepatitis C: and the mystery goes on
    • Brillanti S. Mazzella G. Roda E. (2011) Ribavirin for chronic hepatitis C: and the mystery goes on. Dig Liver Dis 43: 425–430.
    • (2011) Dig Liver Dis , vol.43 , pp. 425-430
    • Brillanti, S.1    Mazzella, G.2    Roda, E.3
  • 10
    • 80053541770 scopus 로고    scopus 로고
    • Boceprevir in addition to standard of care enhanced SVR in hepatitis C virus (HCV) genotype-1 with advanced fibrosis/cirrhosis: subgroup analysis of sprint-2 and respond-2 studies
    • Bruno S. Vierling J.M. Esteban R. Nyberg L.M. Tanno H. Albrecht J.K. et al. (2011) Boceprevir in addition to standard of care enhanced SVR in hepatitis C virus (HCV) genotype-1 with advanced fibrosis/cirrhosis: subgroup analysis of sprint-2 and respond-2 studies. J Hepatol 54 (Suppl. 1): S4.
    • (2011) J Hepatol , vol.54 , pp. S4
    • Bruno, S.1    Vierling, J.M.2    Esteban, R.3    Nyberg, L.M.4    Tanno, H.5    Albrecht, J.K.6
  • 11
    • 84867277602 scopus 로고    scopus 로고
    • Cost-effectiveness of boceprevir use in patients with chronic hepatitis C genotype-1 who failed prior treatment with peginterferon/ribavirin
    • Chhatwal J. Ferrante S.A. Dasbach E.J. El Khoury A. Brass C.A. Burroughs M. et al. (2011) Cost-effectiveness of boceprevir use in patients with chronic hepatitis C genotype-1 who failed prior treatment with peginterferon/ribavirin. Hepatology 54 (Suppl.): 801A.
    • (2011) Hepatology , vol.54 , pp. 801A
    • Chhatwal, J.1    Ferrante, S.A.2    Dasbach, E.J.3    El Khoury, A.4    Brass, C.A.5    Burroughs, M.6
  • 13
    • 79960453276 scopus 로고    scopus 로고
    • Clinical practice guidelines: management of hepatitis C virus infection
    • EASL
    • EASL (2011) Clinical practice guidelines: management of hepatitis C virus infection. J Hepatol 55: 245–264.
    • (2011) J Hepatol , vol.55 , pp. 245-264
  • 14
    • 84867267852 scopus 로고    scopus 로고
    • Cost-effectiveness of boceprevir based regimens in previously untreated adult subjects with chronic hepatitis C genotype 1
    • Ferrante S.A. Chhatwal J. Elbasha E. Dasbach E.J. El Khoury A. Poordad F. et al. (2011) Cost-effectiveness of boceprevir based regimens in previously untreated adult subjects with chronic hepatitis C genotype 1. Hepatology 54 (Suppl.): 795A.
    • (2011) Hepatology , vol.54 , pp. 795A
    • Ferrante, S.A.1    Chhatwal, J.2    Elbasha, E.3    Dasbach, E.J.4    El Khoury, A.5    Poordad, F.6
  • 15
    • 84868668443 scopus 로고    scopus 로고
    • Overall safety profile of boceprevir (BOC) plus peginterferon alfa-2a/ribavirin in genotype 1 previous non-responders and relapsers to peginterferon/ribavirin
    • Flamm S.L. Lawitz E. Jacobson I.M. Bourliere M. Hezode C. Vierling J.M. et al. (2011) Overall safety profile of boceprevir (BOC) plus peginterferon alfa-2a/ribavirin in genotype 1 previous non-responders and relapsers to peginterferon/ribavirin. Hepatology 54 (Suppl.):838A.
    • (2011) Hepatology , vol.54 , pp. 838A
    • Flamm, S.L.1    Lawitz, E.2    Jacobson, I.M.3    Bourliere, M.4    Hezode, C.5    Vierling, J.M.6
  • 16
    • 80052456662 scopus 로고    scopus 로고
    • Boceprevir: a protease inhibitor for the treatment of chronic hepatitis C
    • Foote B.C. Spooner L.M. Belliveau P.P. (2011) Boceprevir: a protease inhibitor for the treatment of chronic hepatitis C. Ann Pharmacother 45: 1085–1093.
    • (2011) Ann Pharmacother , vol.45 , pp. 1085-1093
    • Foote, B.C.1    Spooner, L.M.2    Belliveau, P.P.3
  • 17
    • 84868646706 scopus 로고    scopus 로고
    • Effect of baseline viral load (VL) on response to boceprevir (BOC) plus peginterferon alfa-2b/ribavirin (PR) in patients infected with HCV genotype 1
    • Gordon S.C. Reddy K. McCone J. Jacobson I.M. Esteban R. Pedicone L. et al. (2011) Effect of baseline viral load (VL) on response to boceprevir (BOC) plus peginterferon alfa-2b/ribavirin (PR) in patients infected with HCV genotype 1. Hepatology 54 (Suppl.): 812A.
    • (2011) Hepatology , vol.54 , pp. 812A
    • Gordon, S.C.1    Reddy, K.2    McCone, J.3    Jacobson, I.M.4    Esteban, R.5    Pedicone, L.6
  • 18
    • 79958830099 scopus 로고    scopus 로고
    • Hepatitis C virus resistance to protease inhibitors
    • Halfon P. Locarnini S. (2011) Hepatitis C virus resistance to protease inhibitors. J Hepatol 55: 192–206.
    • (2011) J Hepatol , vol.55 , pp. 192-206
    • Halfon, P.1    Locarnini, S.2
  • 19
    • 80052511465 scopus 로고    scopus 로고
    • Impact of ribavirin on HCV replicon RNA decline during treatment with interferon-α and the protease inhibitors boceprevir or telaprevir
    • Hofmann W.P. Chung T.L. Osbahr C. Susser S. Karey U. Mihm U. et al. (2011) Impact of ribavirin on HCV replicon RNA decline during treatment with interferon-α and the protease inhibitors boceprevir or telaprevir. Antivir Ther 16: 695–704.
    • (2011) Antivir Ther , vol.16 , pp. 695-704
    • Hofmann, W.P.1    Chung, T.L.2    Osbahr, C.3    Susser, S.4    Karey, U.5    Mihm, U.6
  • 20
    • 84862634579 scopus 로고    scopus 로고
    • Treatment week 12 / 24 stopping rules for boceprevir (BOC) combination therapy with peginterferon+ribavirin (PR): exploratory analyses of SPRINT- 2 and RESPOND-2
    • Jacobson I.M. Marcellin P. Zeuzem S. Sulkowski M.S. Esteban R. Pedicone L. et al. (2011) Treatment week 12 / 24 stopping rules for boceprevir (BOC) combination therapy with peginterferon+ribavirin (PR): exploratory analyses of SPRINT- 2 and RESPOND-2. Hepatology 54 (4 Suppl): 808A.
    • (2011) Hepatology , vol.54 , Issue.4 Suppl , pp. 808A
    • Jacobson, I.M.1    Marcellin, P.2    Zeuzem, S.3    Sulkowski, M.S.4    Esteban, R.5    Pedicone, L.6
  • 21
    • 79953198245 scopus 로고    scopus 로고
    • A new therapy era of hepatitis C therapy begins
    • Jensen D.M. (2011) A new therapy era of hepatitis C therapy begins. N Engl J Med 364: 1272–1274.
    • (2011) N Engl J Med , vol.364 , pp. 1272-1274
    • Jensen, D.M.1
  • 22
    • 42149130312 scopus 로고    scopus 로고
    • Future directions in therapy for chronic hepatitis C
    • Jensen D.M. Ascione A. (2008) Future directions in therapy for chronic hepatitis C. Antivir Ther 13 (Suppl. 1): 31–36.
    • (2008) Antivir Ther , vol.13 , pp. 31-36
    • Jensen, D.M.1    Ascione, A.2
  • 23
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS 3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment naïve patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial
    • Kwo P.Y. Lawitz E.J. McCone J. Schiff E.R. Vierling J.M. Pound D. et al. (2010) Efficacy of boceprevir, an NS 3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment naïve patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet 376: 705–716.
    • (2010) Lancet , vol.376 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3    Schiff, E.R.4    Vierling, J.M.5    Pound, D.6
  • 24
    • 84860311682 scopus 로고    scopus 로고
    • The effect of using lower limit of quantitation (LLQ) vs lower limit of detection (LLD) for the definition of undetectable HCV RNA: data from the RESPOND-2 and SPINT-2 trials
    • Lawitz E. Poordad F. Bronowicki J. Marcellin P. Feinman V.S. Kwo P.Y. et al. (2011) The effect of using lower limit of quantitation (LLQ) vs lower limit of detection (LLD) for the definition of undetectable HCV RNA: data from the RESPOND-2 and SPINT-2 trials. Hepatology 54 (Suppl.): 442A.
    • (2011) Hepatology , vol.54 , pp. 442A
    • Lawitz, E.1    Poordad, F.2    Bronowicki, J.3    Marcellin, P.4    Feinman, V.S.5    Kwo, P.Y.6
  • 25
    • 84855214501 scopus 로고    scopus 로고
    • Safety benefits of response-guided therapy with boceprevir (BOC) plus peginterferon alfa – 2b/ribavirin (PR) in previously untreated patients with HCV genotype 1 infection
    • Manns M.P. McCone J. Davis M. Shiffman M.L. Rossaro L. Bourliere M. et al. (2011) Safety benefits of response-guided therapy with boceprevir (BOC) plus peginterferon alfa – 2b/ribavirin (PR) in previously untreated patients with HCV genotype 1 infection. Hepatology 54 (Suppl.): 813A.
    • (2011) Hepatology , vol.54 , pp. 813A
    • Manns, M.P.1    McCone, J.2    Davis, M.3    Shiffman, M.L.4    Rossaro, L.5    Bourliere, M.6
  • 27
    • 84868657922 scopus 로고    scopus 로고
    • Genotypic and phenotypic correlates of resistance in HCV genotype 1a and 1b infected patients treated with boceprevir plus peginterferon alpha and ribavirin
    • Ogert R.A. McMonagle P. Black S. Curry S. Guo Z. Lesburg C. et al. (2011) Genotypic and phenotypic correlates of resistance in HCV genotype 1a and 1b infected patients treated with boceprevir plus peginterferon alpha and ribavirin. Hepatology 54 (Suppl.): 794A.
    • (2011) Hepatology , vol.54 , pp. 794A
    • Ogert, R.A.1    McMonagle, P.2    Black, S.3    Curry, S.4    Guo, Z.5    Lesburg, C.6
  • 28
    • 79960449077 scopus 로고    scopus 로고
    • Il28b Polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (Boc) combination therapy
    • Poordad F. Bronowicki J.-P. Gordon S.C. Zeuzem S. Jacobson I.M. Sulkowski M.S. et al. (2011 c) Il28b Polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (Boc) combination therapy. J Hepatol 54 (Suppl. 1): S6.
    • (2011) J Hepatol , vol.54 , pp. S6
    • Poordad, F.1    Bronowicki, J.-P.2    Gordon, S.C.3    Zeuzem, S.4    Jacobson, I.M.5    Sulkowski, M.S.6
  • 29
    • 84858272957 scopus 로고    scopus 로고
    • Concomitant medication use in patients with hepatitis c genotype 1 treated with boceprevir (BOC) combination therapy
    • Poordad F. Lawitz E. Gordon S.C. Bourli M. Vierling J.M. Poynard T. et al. (2011 b) Concomitant medication use in patients with hepatitis c genotype 1 treated with boceprevir (BOC) combination therapy. Hepatology 54 (Suppl.): 799A.
    • (2011) Hepatology , vol.54 , pp. 799A
    • Poordad, F.1    Lawitz, E.2    Gordon, S.C.3    Bourli, M.4    Vierling, J.M.5    Poynard, T.6
  • 31
    • 84861196071 scopus 로고    scopus 로고
    • An evaluation of neutropenia in the pivotal studies of boceprevir (BOC) plus peginterferonalfa – 2b/ribavirin (PR)
    • Reddy K. Nunes F. Balart L.A. Sjogren R. Pedicone L. Burroughs M. et al. (2011) An evaluation of neutropenia in the pivotal studies of boceprevir (BOC) plus peginterferonalfa – 2b/ribavirin (PR). Hepatology 54 (Suppl.): 814A.
    • (2011) Hepatology , vol.54 , pp. 814A
    • Reddy, K.1    Nunes, F.2    Balart, L.A.3    Sjogren, R.4    Pedicone, L.5    Burroughs, M.6
  • 32
    • 72249083270 scopus 로고    scopus 로고
    • Randomized study of peginterferon-alpha2a plus ribavirin vs peginterferon-alpha2b plus ribavirin in chronic hepatitis C
    • Rumi M.G. Aghemo A. Prati G.M. D'Ambrosio R. Donato M.F. Soffredini R. et al. (2010) Randomized study of peginterferon-alpha2a plus ribavirin vs peginterferon-alpha2b plus ribavirin in chronic hepatitis C. Gastroenterology 138: 108–115.
    • (2010) Gastroenterology , vol.138 , pp. 108-115
    • Rumi, M.G.1    Aghemo, A.2    Prati, G.M.3    D'Ambrosio, R.4    Donato, M.F.5    Soffredini, R.6
  • 33
    • 84868638361 scopus 로고    scopus 로고
    • Assessment of Boceprevir pharmacokinetic / pharmacodynamic relationships for sustained viral response and occurrence of anemia from phase 3 data
    • Stone J.A. Wenning L.A. Hang Y. Su J. Gupta S. Tsai K. et al. (2011) Assessment of Boceprevir pharmacokinetic / pharmacodynamic relationships for sustained viral response and occurrence of anemia from phase 3 data. Hepatology 54 (Suppl.): 993A.
    • (2011) Hepatology , vol.54 , pp. 993A
    • Stone, J.A.1    Wenning, L.A.2    Hang, Y.3    Su, J.4    Gupta, S.5    Tsai, K.6
  • 34
    • 84860315708 scopus 로고    scopus 로고
    • ITPA deficiency is associated with lower rates of anemia and EPO use in patients treated with boceprevir (BOC) plus peginterferon / ribavirin (PR)
    • Sulkowski M.S. Reddy K. Pedicone L. Shen J. Burroughs M. Brass C.A. et al. (2011) ITPA deficiency is associated with lower rates of anemia and EPO use in patients treated with boceprevir (BOC) plus peginterferon / ribavirin (PR). Hepatology 54 (Suppl.): 798A.
    • (2011) Hepatology , vol.54 , pp. 798A
    • Sulkowski, M.S.1    Reddy, K.2    Pedicone, L.3    Shen, J.4    Burroughs, M.5    Brass, C.A.6
  • 35
    • 84993787279 scopus 로고    scopus 로고
    • Victrelis
    • Merck & Co., Inc. Whitehouse Station, NJ, USA
    • Victrelis (2011) Package insert. Merck & Co., Inc. Whitehouse Station, NJ, USA.
    • (2011) Package insert
  • 36
    • 84858167086 scopus 로고    scopus 로고
    • Efficacy of boceprevir in prior null responders to peginterferon/ribavirin: the PROVIDE study
    • Vierling J.M. Flamm S.L. Gordon S.C. Lawitz E. Bronowicki J. Davis M. et al. (2011) Efficacy of boceprevir in prior null responders to peginterferon/ribavirin: the PROVIDE study. Hepatology 54 (Suppl.): 796A.
    • (2011) Hepatology , vol.54 , pp. 796A
    • Vierling, J.M.1    Flamm, S.L.2    Gordon, S.C.3    Lawitz, E.4    Bronowicki, J.5    Davis, M.6


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