-
1
-
-
1842479859
-
Diagnosis, Management, and Treatment of Hepatitis C
-
DOI 10.1002/hep.20119
-
Strader D.B., Wright T., Thomas D.L., Seeff L.B. Diagnosis, management, and treatment of hepatitis C. Hepatology 2004; 39:1147-1171. (Pubitemid 38428955)
-
(2004)
Hepatology
, vol.39
, Issue.4
, pp. 1147-1171
-
-
Strader, D.B.1
Wright, T.2
Thomas, D.L.3
Seeff, L.B.4
-
2
-
-
7044272630
-
Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
-
DOI 10.1053/j.gastro.2004.09.014, PII S0016508504015938
-
Fattovich G., Stroffolini T., Zagni I., Donato F. Hepatocellular carcinoma in cirrhosis: Incidence and risk factors. Gastroenterology 2004; 127:S35-S50. (Pubitemid 39423368)
-
(2004)
Gastroenterology
, vol.127
, Issue.SUPPL.
-
-
Fattovich, G.1
Stroffolini, T.2
Zagni, I.3
Donato, F.4
-
3
-
-
38449091418
-
Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis
-
Veldt B.J., Heathcote E.J., Wedemeyer H., et al. Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Ann Intern Med 2007; 147:677-684. (Pubitemid 351664462)
-
(2007)
Annals of Internal Medicine
, vol.147
, Issue.10
, pp. 677-684
-
-
Veldt, B.J.1
Heathcote, E.J.2
Wedemeyer, H.3
Reichen, J.4
Hofmann, W.P.5
Zeuzem, S.6
Manns, M.P.7
Hansen, B.E.8
Schalm, S.W.9
Janssen, H.L.A.10
-
4
-
-
33845449051
-
Peginterferon and ribavirin for chronic hepatitis C
-
DOI 10.1056/NEJMct061675
-
Hoofnagle J.H., Seeff L.B. Peginterferon and ribavirin for chronic hepatitis C. N Engl J Med 2006; 355:2444-2451. (Pubitemid 44903748)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.23
, pp. 2444-2451
-
-
Hoofnagle, J.H.1
Seeff, L.B.2
-
5
-
-
36749001029
-
The way forward in HCV treatment - Finding the right path
-
DOI 10.1038/nrd2411, PII NRD2411
-
Manns M.P., Foster G.R., Rockstroh J.K., Zeuzem S., Zoulim F., Houghton M. The way forward in HCV treatment - Finding the right path. Nat Rev Drug Discov 2007; 6:991-1000. (Pubitemid 350201789)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.12
, pp. 991-1000
-
-
Manns, M.P.1
Foster, G.R.2
Rockstroh, J.K.3
Zeuzem, S.4
Zoulim, F.5
Houghton, M.6
-
6
-
-
34247895578
-
The Hepatitis C Virus Life Cycle as a Target for New Antiviral Therapies
-
DOI 10.1053/j.gastro.2007.03.116, PII S0016508507006427
-
Pawlotsky J.M., Chevaliez S., McHutchison J.G. The hepatitis C virus life cycle as a target for new antiviral therapies. Gastroenterology 2007; 132:1979-1998. (Pubitemid 46695724)
-
(2007)
Gastroenterology
, vol.132
, Issue.5
, pp. 1979-1998
-
-
Pawlotsky, J.1
Chevaliez, S.2
McHutchison, J.G.3
-
7
-
-
77956268467
-
Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An open-label, randomised, multicentre Phase 2 trial
-
Kwo P.Y., Lawitz E.J., McCone J., et al. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An open-label, randomised, multicentre Phase 2 trial. Lancet 2010; 376:705-716.
-
(2010)
Lancet
, vol.376
, pp. 705-716
-
-
Kwo, P.Y.1
Lawitz, E.J.2
McCone, J.3
-
8
-
-
65449171953
-
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
-
Hézode C., Forestier N., Dusheiko G., et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009; 360:1839-1850.
-
(2009)
N Engl J Med
, vol.360
, pp. 1839-1850
-
-
Hézode, C.1
Forestier, N.2
Dusheiko, G.3
-
10
-
-
44649113041
-
Clinical trial: Exposure to ribavirin predicts EVR and SVR in patients with HCV genotype 1 infection treated with peginterferon alfa-2a plus ribavirin
-
DOI 10.1111/j.1365-2036.2008.03705.x
-
Bain V.G., Lee S.S., Peltekian K., et al. Clinical trial: Exposure to ribavirin predicts EVR and SVR in patients with HCV genotype 1 infection treated with peginterferon alfa-2a plus ribavirin. Aliment Pharmacol Ther 2008; 28:43-50. (Pubitemid 351782811)
-
(2008)
Alimentary Pharmacology and Therapeutics
, vol.28
, Issue.1
, pp. 43-50
-
-
Bain, V.G.1
Lee, S.S.2
Peltekian, K.3
Yoshida, E.M.4
Deschenes, M.5
Sherman, M.6
Bailey, R.7
Witt-Sullivan, H.8
Balshaw, R.9
Krajden, M.10
-
11
-
-
47649106599
-
Prediction of sustained virological response by ribavirin plasma concentration at week 4 of therapy in hepatitis C virus genotype 1 patients
-
Maynard M., Gagnieu M.C., Pradat P., Souvignet C., Trepo C. Prediction of sustained virological response by ribavirin plasma concentration at week 4 of therapy in hepatitis C virus genotype 1 patients. Antivir Ther 2008; 13:607-611. (Pubitemid 352016724)
-
(2008)
Antiviral Therapy
, vol.13
, Issue.4
, pp. 607-611
-
-
Maynard, M.1
Pradat, P.2
Gagnieu, M.-C.3
Souvignet, C.4
Trepo, C.5
-
12
-
-
43949119161
-
Ribavirin exposure after the first dose is predictive of sustained virological response in chronic hepatitis C
-
DOI 10.1002/hep.22217
-
Loustaud-Ratti V., Alain S., Rousseau A., et al. Ribavirin exposure after the first dose is predictive of sustained virological response in chronic hepatitis C. Hepatology 2008; 47:1453-1461. (Pubitemid 351702729)
-
(2008)
Hepatology
, vol.47
, Issue.5
, pp. 1453-1461
-
-
Loustaud-Ratti, V.1
Alain, S.2
Rousseau, A.3
Hubert, I.F.4
Sauvage, F.L.5
Marquet, P.6
Denis, F.7
Lunel, F.8
Cales, P.9
Lefebvre, A.10
Fauchais, A.-L.11
Liozon, E.12
Vidal, E.13
-
13
-
-
78049460599
-
Hepatitis C virus treatment-related anemia is associated with higher sustained virological response rate
-
Sulkowski M., Shiffman M., Afdhal N., et al. Hepatitis C virus treatment-related anemia is associated with higher sustained virological response rate. Gastroenterology 2010; 139:1602-1611.
-
(2010)
Gastroenterology
, vol.139
, pp. 1602-1611
-
-
Sulkowski, M.1
Shiffman, M.2
Afdhal, N.3
-
14
-
-
33846246344
-
Impact of Ribavirin Dose Reductions in Hepatitis C Virus Genotype 1 Patients Completing Peginterferon Alfa-2a/Ribavirin Treatment
-
DOI 10.1016/j.cgh.2006.10.008, PII S1542356506010469
-
Reddy K.R., Shiffman M.L., Morgan T.R., et al. Impact of ribavirin dose reductions in hepatitis C virus genotype 1 patients completing peginterferon alfa-2a/ribavirin treatment. Clin Gastroenterol Hepatol 2007; 5:124-129. (Pubitemid 46096836)
-
(2007)
Clinical Gastroenterology and Hepatology
, vol.5
, Issue.1
, pp. 124-129
-
-
Reddy, K.R.1
Shiffman, M.L.2
Morgan, T.R.3
Zeuzem, S.4
Hadziyannis, S.5
Hamzeh, F.M.6
Wright, T.L.7
Fried, M.8
-
15
-
-
0035157218
-
Mutations in hepatitis C virus RNAs conferring cell culture adaptation
-
DOI 10.1128/JVI.75.3.1437-1449.2001
-
Lohmann V., Korner F., Dobierzewska A., Bartenschlager R. Mutations in hepatitis C virus RNAs conferring cell culture adaptation. J Virol 2001; 75:1437-1449. (Pubitemid 32094702)
-
(2001)
Journal of Virology
, vol.75
, Issue.3
, pp. 1437-1449
-
-
Lohmann, V.1
Korner, F.2
Dobierzewska, A.3
Bartenschlager, R.4
-
16
-
-
33947320164
-
Mutagenic Effect of Ribavirin on Hepatitis C Nonstructural 5B Quasispecies In Vitro and During Antiviral Therapy
-
DOI 10.1053/j.gastro.2006.12.005, PII S0016508506025637
-
Hofmann W.P., Polta A., Herrmann E., et al. Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy. Gastroenterology 2007; 132:921-930. (Pubitemid 46440857)
-
(2007)
Gastroenterology
, vol.132
, Issue.3
, pp. 921-930
-
-
Hofmann, W.P.1
Polta, A.2
Herrmann, E.3
Mihm, U.4
Kronenberger, B.5
Sonntag, T.6
Lohmann, V.7
Schonberger, B.8
Zeuzem, S.9
Sarrazin, C.10
-
18
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco W.R., Bravo G., Parsons J.C. The search for synergy: A critical review from a response surface perspective. Pharmacol Rev 1995; 47:331-385.
-
(1995)
Pharmacol Rev
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
19
-
-
0031596029
-
Nucleosides analog 1592U89 and human immunodeficiency virus protease inhibitor 141W94 are synergistic in vitro
-
Drusano G.L., D'Argenio D.Z., Symonds W., et al. Nucleoside analog 1592U89 and human immunodeficiency virus protease inhibitor 141W94 are synergistic in vitro. Antimicrob Agents Chemother 1998; 42:2153-2159. (Pubitemid 28420342)
-
(1998)
Antimicrobial Agents and Chemotherapy
, vol.42
, Issue.9
, pp. 2153-2159
-
-
Drusano, G.L.1
D'Argenio, D.Z.2
Symonds, W.3
Bilello, P.A.4
McDowell, J.5
Sadler, B.6
Bye, A.7
Bilello, J.A.8
-
20
-
-
9644275435
-
Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells
-
DOI 10.1128/AAC.48.12.4784-4792.2004
-
Lin K., Kwong A.D., Lin C. Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells. Antimicrob Agents Chemother 2004; 48:4784-4792. (Pubitemid 39577685)
-
(2004)
Antimicrobial Agents and Chemotherapy
, vol.48
, Issue.12
, pp. 4784-4792
-
-
Lin, K.1
Kwong, A.D.2
Lin, C.3
-
21
-
-
0024993530
-
A three-dimensional model to analyze drug-drug interactions
-
Prichard M.N., Shipman C., Jr. A three-dimensional model to analyze drug-drug interactions. Antiviral Res 1990; 14:181-205. (Pubitemid 20377558)
-
(1990)
Antiviral Research
, vol.14
, Issue.4-5
, pp. 181-205
-
-
Prichard, M.N.1
Shipman Jr., C.2
-
22
-
-
33749518268
-
Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2′-C-methylcytidine, the active component of valopicitabine
-
DOI 10.1128/AAC.00372-06
-
Coelmont L., Paeshuyse J., Windisch M.P., De Clercq E., Bartenschlager R., Neyts J. Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2′-C-methylcytidine, the active component of valopicitabine. Antimicrob Agents Chemother 2006; 50:3444-3446. (Pubitemid 44527521)
-
(2006)
Antimicrobial Agents and Chemotherapy
, vol.50
, Issue.10
, pp. 3444-3446
-
-
Coelmont, L.1
Paeshuyse, J.2
Windisch, M.P.3
De Clercq, E.4
Bartenschlager, R.5
Neyts, J.6
-
23
-
-
59149106172
-
What future for ribavirin?
-
Shiffman M.L. What future for ribavirin? Liver Int 2009; 29 Suppl 1:68-73.
-
(2009)
Liver Int
, vol.29
, Issue.SUPPL. 1
, pp. 68-73
-
-
Shiffman, M.L.1
-
24
-
-
30744469345
-
Erythrocyte ribavirin concentration for assessing hemoglobin reduction in interferon and ribavirin combination therapy
-
DOI 10.1016/j.hepres.2005.10.003, PII S1386634605003323
-
Inoue Y., Homma M., Matsuzaki Y., et al. Erythrocyte ribavirin concentration for assessing hemoglobin reduction in interferon and ribavirin combination therapy. Hepatol Res 2006; 34:23-27. (Pubitemid 43091872)
-
(2006)
Hepatology Research
, vol.34
, Issue.1
, pp. 23-27
-
-
Inoue, Y.1
Homma, M.2
Matsuzaki, Y.3
Shibata, M.4
Matsumura, T.5
Ito, T.6
Kohda, Y.7
-
25
-
-
1842427473
-
Marked elevation of erythrocyte ribavirin levels in interferon and ribavirin-induced anemia
-
DOI 10.1016/S1542-3565(04)00064-3, PII S1542356504000643
-
Homma M., Matsuzaki Y., Inoue Y., et al. Marked elevation of erythrocyte ribavirin levels in interferon and ribavirininduced anemia. Clin Gastroenterol Hepatol 2004; 2:337-339. (Pubitemid 38447199)
-
(2004)
Clinical Gastroenterology and Hepatology
, vol.2
, Issue.4
, pp. 337-339
-
-
Homma, M.1
Matsuzaki, Y.2
Inoue, Y.3
Shibata, M.4
Mitamura, K.5
Tanaka, N.6
Kohda, Y.7
-
26
-
-
50949132884
-
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors
-
Paeshuyse J., Vliegen I., Coelmont L., et al. Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. Antimicrob Agents Chemother 2008; 52:3433-3437.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 3433-3437
-
-
Paeshuyse, J.1
Vliegen, I.2
Coelmont, L.3
-
27
-
-
33846521154
-
Viral determinants of resistance to treatment in patients with hepatitis C
-
DOI 10.1128/CMR.00010-06
-
Wohnsland A., Hofmann W.P., Sarrazin C. Viral determinants of resistance to treatment in patients with hepatitis C. Clin Microbiol Rev 2007; 20:23-38. (Pubitemid 46167766)
-
(2007)
Clinical Microbiology Reviews
, vol.20
, Issue.1
, pp. 23-38
-
-
Wohnsland, A.1
Hofmann, W.P.2
Sarrazin, C.3
-
28
-
-
38649096600
-
Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop
-
DOI 10.1002/hep.22070
-
Chung R.T., Gale M., Jr, Polyak S.J., Lemon S.M., Liang T.J., Hoofnagle J.H. Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop. Hepatology 2008; 47:306-320. (Pubitemid 351171068)
-
(2008)
Hepatology
, vol.47
, Issue.1
, pp. 306-320
-
-
Chung, R.T.1
Gale Jr., M.2
Polyak, S.J.3
Lemon, S.M.4
Liang, T.J.5
Hoofnagle, J.H.6
-
29
-
-
11144358183
-
Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha
-
DOI 10.1086/382595
-
Tanabe Y., Sakamoto N., Enomoto N., et al. Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon-alpha. J Infect Dis 2004; 189:1129-1139. (Pubitemid 38457235)
-
(2004)
Journal of Infectious Diseases
, vol.189
, Issue.7
, pp. 1129-1139
-
-
Tanabe, Y.1
Sakamoto, N.2
Enomoto, N.3
Kurosaki, M.4
Ueda, E.5
Maekawa, S.6
Yamashiro, T.7
Nakagawa, M.8
Chen, C.-H.9
Kanazawa, N.10
Kakinuma, S.11
Watanabe, M.12
-
30
-
-
27744537836
-
Detection of anti-hepatitis C virus effects of interferon and ribavirin by a sensitive replicon system
-
DOI 10.1128/JCM.43.11.5679-5684.2005
-
Kato T., Date T., Miyamoto M., et al. Detection of anti-hepatitis C virus effects of interferon and ribavirin by a sensitive replicon system. J Clin Microbiol 2005; 43:5679-5684. (Pubitemid 41612348)
-
(2005)
Journal of Clinical Microbiology
, vol.43
, Issue.11
, pp. 5679-5684
-
-
Kato, T.1
Date, T.2
Miyamoto, M.3
Sugiyama, M.4
Tanaka, Y.5
Orito, E.6
Ohno, T.7
Sugihara, K.8
Hasegawa, I.9
Fujiwara, K.10
Ito, K.11
Ozasa, A.12
Mizokami, M.13
Wakita, T.14
-
31
-
-
65749112245
-
In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor
-
Lin T.I., Lenz O., Fanning G., et al. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor. Antimicrob Agents Chemother 2009; 53:1377-1385.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 1377-1385
-
-
Lin, T.I.1
Lenz, O.2
Fanning, G.3
-
32
-
-
23944462641
-
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
-
DOI 10.1038/nature04082
-
Feld J.J., Hoofnagle J.H. Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature 2005; 436:967-972. (Pubitemid 41191673)
-
(2005)
Nature
, vol.436
, Issue.7053
, pp. 967-972
-
-
Feld, J.J.1
Hoofnagle, J.H.2
-
33
-
-
54049097126
-
Ribavirin mode of action in chronic hepatitis C: From clinical use back to molecular mechanisms
-
Hofmann W.P., Herrmann E., Sarrazin C., Zeuzem S. Ribavirin mode of action in chronic hepatitis C: From clinical use back to molecular mechanisms. Liver Int 2008; 28:1332-1343.
-
(2008)
Liver Int
, vol.28
, pp. 1332-1343
-
-
Hofmann, W.P.1
Herrmann, E.2
Sarrazin, C.3
Zeuzem, S.4
-
34
-
-
36348960622
-
Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response
-
DOI 10.1002/hep.21853
-
Feld J.J., Nanda S., Huang Y., et al. Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response. Hepatology 2007; 46:1548-1563. (Pubitemid 350155537)
-
(2007)
Hepatology
, vol.46
, Issue.5
, pp. 1548-1563
-
-
Feld, J.J.1
Nanda, S.2
Huang, Y.3
Chen, W.4
Cam, M.5
Pusek, S.N.6
Schweigler, L.M.7
Theodore, D.8
Zacks, S.L.9
Liang, T.J.10
Fried, M.W.11
-
35
-
-
78751545582
-
Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models
-
Thomas E., Feld J.J., Li Q., Hu Z., Fried M.W., Liang T.J. Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models. Hepatology 2011; 53:32-41.
-
(2011)
Hepatology
, vol.53
, pp. 32-41
-
-
Thomas, E.1
Feld, J.J.2
Li, Q.3
Hu, Z.4
Fried, M.W.5
Liang, T.J.6
-
36
-
-
0023122258
-
Ribavirin antagonizes the effect of azidothymidine on HIV replication
-
Vogt M.W., Hartshorn K.L., Furman P.A., et al. Ribavirin antagonizes the effect of azidothymidine on HIV replication. Science 1987; 235:1376-1379. (Pubitemid 17041656)
-
(1987)
Science
, vol.235
, Issue.4794
, pp. 1376-1379
-
-
Vogt, M.W.1
Hartshorn, K.L.2
Furman, P.A.3
-
37
-
-
48249154950
-
Anti-HCV activity and cellular pharmacology of 2′-Cmethyl- Cytidine alone and in combination with non-toxic concentrations of ribavirin in the HCV replicon system
-
Hernandez-Santiago B.I., Bassit L., Grier J., Schinazi R.F. Anti-HCV activity and cellular pharmacology of 2′-Cmethyl- cytidine alone and in combination with non-toxic concentrations of ribavirin in the HCV replicon system. Antivir Ther 2007; 12 Suppl 1:S28.
-
(2007)
Antivir Ther
, vol.12
, Issue.SUPPL. 1
-
-
Hernandez-Santiago, B.I.1
Bassit, L.2
Grier, J.3
Schinazi, R.F.4
-
38
-
-
75149151884
-
Resistance to direct antiviral agents in patients with hepatitis C virus infection
-
Sarrazin C., Zeuzem S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology 2010; 138:447-462.
-
(2010)
Gastroenterology
, vol.138
, pp. 447-462
-
-
Sarrazin, C.1
Zeuzem, S.2
-
39
-
-
50949096105
-
Combinations of cyclophilin inhibitor NIM811 with hepatitis C virus NS3-4A protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance
-
Mathy J.E., Ma S., Compton T., Lin K. Combinations of cyclophilin inhibitor NIM811 with hepatitis C virus NS3-4A protease or NS5B polymerase inhibitors enhance antiviral activity and suppress the emergence of resistance. Antimicrob Agents Chemother 2008; 52:3267-3275.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 3267-3275
-
-
Mathy, J.E.1
Ma, S.2
Compton, T.3
Lin, K.4
-
40
-
-
62949181285
-
Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors
-
Coelmont L., Kaptein S., Paeshuyse J., et al. Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. Antimicrob Agents Chemother 2009; 53:967-976.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 967-976
-
-
Coelmont, L.1
Kaptein, S.2
Paeshuyse, J.3
|