Relationship of sympathetic activity to bone microstructure, turnover, and plasma osteopontin levels in women

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 11, 2012, Pages 4219-4227

  Farr, Joshua N ^a   Charkoudian, Nisha ^b   Barnes, Jill N ^a   Monroe, David G ^a   McCready, Louise K ^a   Atkinson, Elizabeth J ^a   Amin, Shreyasee ^a   Melton III, L Joseph ^a   Joyner, Michael J ^a   Khosla, Sundeep ^a  

^a MAYO CLINIC   (United States)

^b U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; BETA ADRENERGIC RECEPTOR; COLLAGEN TYPE 1; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; OSTEOPROTEGERIN;

ADULT; AGED; ARTICLE; BONE MASS; BONE METABOLISM; BONE STRUCTURE; BONE TURNOVER; FEEDBACK SYSTEM; FEMALE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; OSTEOLYSIS; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SYMPATHETIC TONE; THICKNESS; TRABECULAR BONE;

ADULT; AGED; BONE AND BONES; BONE DENSITY; FEMALE; HUMANS; MIDDLE AGED; OSTEOPONTIN; PERONEAL NERVE; POSTMENOPAUSE; PREMENOPAUSE; SYMPATHETIC NERVOUS SYSTEM;

RODENTIA;

EID: 84868624317     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2381     Document Type: Article

References (37)

1. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G 2002 Leptin regulates bone formation via the sympathetic nervous system. Cell 111:305-317 (Pubitemid 35345151)
2. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G 2005 Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434:514-520 (Pubitemid 40477060)
3. Nagao M, Feinstein TN, Ezura Y, Hayata T, Notomi T, Saita Y, Hanyu R, Hemmi H, Izu Y, Takeda S, Wang K, Rittling S, Nakamoto T, Kaneko K, Kurosawa H, Karsenty G, Denhardt DT, Vilardaga JP, Noda M 2011 Sympathetic control of bone mass regulated by osteopontin. Proc Natl Acad Sci USA 108:17767-17772
4. Moore RE, Smith 2nd CK, Bailey CS, Voelkel EF, Tashjian Jr AH 1993 Characterization of β-adrenergic receptors on rat and human osteoblast-like cells and demonstration that beta-receptor agonists can stimulate bone resorption in organ culture. Bone Miner 23:301-315
5. Kellenberger S, Muller K, Richener H, Bilbe G 1998 Formoterol and isoproterenol induce c-fos gene expression in osteoblast-like cells by activating β2-adrenergic receptors. Bone 22:471-478 (Pubitemid 28226860)
6. Bouxsein ML, Devlin MJ, Glatt V, Dhillon H, Pierroz DD, Ferrari SL 2009 Mice lacking β-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy. Endocrinology 150:144-152
7. Wiens M, Etminan M, Gill SS, Takkouche B 2006 Effects of antihypertensive drug treatments on fracture outcomes: a meta-analysis of observational studies. J Intern Med 260:350-362 (Pubitemid 44370908)
8. Levasseur R, Dargent-Molina P, Sabatier JP, Marcelli C, Bréart G 2005 β-Blocker use, bone mineral density, and fracture risk in older women: results from the Epidemiologie de l'Osteoporose prospective study. J Am Geriatr Soc 53:550-552 (Pubitemid 41623546)
9. Pierroz DD, Bonnet N, Bianchi EN, Bouxsein ML, Baldock PA, Rizzoli R, Ferrari SL 2012 Deletion of β-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation. J Bone Miner Res 27:1252-1262
10. Bonnet N, Laroche N, Vico L, Dolleans E, Benhamou CL, Courteix D 2006 Dose effects of propranolol on cancellous and cortical bone in ovariectomized adult rats. J Pharmacol Exp Ther 318:1118-1127 (Pubitemid 44274974)
11. Sato T, Arai M, Goto S, Togari A 2010 Effects of propranolol on bone metabolism in spontaneously hypertensive rats. J Pharmacol Exp Ther 334:99-105
12. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ 1997 Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309-319 (Pubitemid 27199902)
13. Li X, Ominsky MS, Niu QT, Sun N, Daugherty B, D'Agostin D, Kurahara C, Gao Y, Cao J, Gong J, Asuncion F, Barrero M, Warmington K, Dwyer D, Stolina M, Morony S, Sarosi I, Kostenuik PJ, Lacey DL, Simonet WS, Ke HZ, Paszty C 2008 Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 23:860-869 (Pubitemid 351768804)
14. Mödder UI, Hoey KA, Amin S, McCready LK, Achenbach SJ, Riggs BL, Melton 3rd LJ, Khosla S 2011 Relation of age, gender, and bone mass to circulating sclerostin levels inwomenand men. J Bone Miner Res 26:373-379
15. Charkoudian N, Joyner MJ, Johnson CP, Eisenach JH, Dietz NM, Wallin BG 2005 Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation. J Physiol 568:315-321 (Pubitemid 41448640)
16. Charkoudian N, Joyner MJ, Sokolnicki LA, Johnson CP, Eisenach JH, Dietz NM, Curry TB, Wallin BG 2006 Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans. J Physiol 572:821-827
17. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach J, Joyner MJ 2011 Sex and ageing differences in resting arterial pressure regulation: the role of the β-adrenergic receptors. J Physiol 589:5285-5297
18. Sundlöf G, Wallin BG 1977 The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol 272:383-397 (Pubitemid 8200922)
19. Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton 3rd LJ 2006 Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res 21:124-131 (Pubitemid 43023234)
20. Laib A, Hildebrand T, Häuselmann HJ, Rüegsegger P 1997 Ridge number density: a new parameter for in vivo bone structure analysis. Bone 21:541-546 (Pubitemid 28029698)
21. Laib A, Häuselmann HJ, Rüegsegger P 1998 In vivo high resolution 3D-QCT of the human forearm. Technol Health Care 6:329-337 (Pubitemid 29090456)
22. Laib A, Rüegsegger P 1999 Calibration of trabecular bone structure measurements of in vivo three-dimensional peripheral quantitative computed tomography with 28-microm-resolution microcomputed tomography. Bone 24:35-39 (Pubitemid 28546704)
23. Nicks KM, Amin S, Atkinson EJ, Riggs BL, Melton 3rd LJ, Khosla S 2012 Relationship of age to bone microstructure independent of areal bone mineral density. J Bone Miner Res 27:637-644
24. Kazakia GJ, Hyun B, Burghardt AJ, Krug R, Newitt DC, de Papp AE, Link TM, Majumdar S 2008 In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging. J Bone Miner Res 23:463-474 (Pubitemid 351501886)
25. Buie HR, Campbell GM, Klinck RJ, MacNeil JA, Boyd SK 2007 Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis. Bone 41:505-515 (Pubitemid 47385446)
26. Burghardt AJ, Buie HR, Laib A, Majumdar S, Boyd SK 2010 Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT. Bone 47:519-528
27. Burghardt AJ, Kazakia GJ, Ramachandran S, Link TM, Majumdar S 2010 Age- and gender-related differences in the geometric properties and biomechanical significance of intra-cortical porosity in the distal radius and tibia. J Bone Miner Res 25:983-993
28. Nishiyama KK, Macdonald HM, Buie HR, Hanley DA, Boyd SK 2010 Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study. J Bone Miner Res 25:882-890
29. Pistoia W, van Rietbergen B, Lochmüller EM, Lill CA, Eckstein F, Rüegsegger P 2002 Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30:842-848 (Pubitemid 34616011)
30. Reid IR, Lucas J, Wattie D, Horne A, Bolland M, Gamble GD, Davidson JS, Grey AB 2005 Effects of a β-blocker on bone turnover in normal postmenopausal women: a randomized controlled trial. J Clin Endocrinol Metab 90:5212-5216 (Pubitemid 41262276)
31. Reid IR 2004 Leptin deficiency: lessons in regional differences in the regulation of bone mass. Bone 34:369-371 (Pubitemid 38314900)
32. Rogers A, Eastell R 2005 Review: circulating osteoprotegerin and receptor activator for nuclear factor κB ligand: clinical utility in metabolic bone disease assessment. J Clin Endocrinol Metab 90:6323-6331 (Pubitemid 41606564)
33. Chen D, Sarikaya NA, Gunn H, Martin SW, Young JD 2001 ELISA methodology for detection of modified osteoprotegerin in clinical studies. Clin Chem 47:747-749 (Pubitemid 32275821)
34. Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL 2003 Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest 111:1221-1230 (Pubitemid 36519939)
35. Minson CT, Halliwill JR, Young TM, Joyner MJ 2000 Sympathetic activity and baroreflex sensitivity in young women taking oral contraceptives. Circulation 102:1473-1476
36. Minson CT, Halliwill JR, Young TM, Joyner MJ 2000 Influence of the menstrual cycle on sympathetic activity, baroreflex sensitivity, and vascular transduction in young women. Circulation 101:862-868 (Pubitemid 30117881)
37. Wallin BG, Charkoudian N 2007 Sympathetic neural control of integrated cardiovascular function: insights from measurement of human sympathetic nerve activity. Muscle Nerve 36:595-614 (Pubitemid 47623848)