Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis

Journal of Bacteriology

Volumn 194, Issue 20, 2012, Pages 5621-5631

  Weiss, Leslie A ^a   Harrison, Phillip G ^a   Nickels, Bryce E ^b   Glickman, Michael S ^d   Campbell, Elizabeth A ^c   Darst, Seth A ^c   Stallings, Christina L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; RIFAMPICIN; RNA POLYMERASE BETA SUBUNIT; STREPTOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL VIABILITY; CONTROLLED STUDY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TUBERCULOSIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; DNA-DIRECTED RNA POLYMERASES; DRUG RESISTANCE, BACTERIAL; MICROBIAL VIABILITY; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MYCOBACTERIUM TUBERCULOSIS; POINT MUTATION; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RIFAMPIN; TRANSCRIPTION FACTORS; VIRULENCE;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 84868595942     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00879-12     Document Type: Article

References (26)

1. Akey D, et al. 2006. Crystal structure and nonhomologous end-joining function of the ligase component of MycobacteriumDNAligase D. J. Biol. Chem. 281:13412-13423.
2. Aniukwu J, Glickman MS, Shuman S. 2008. The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes Dev. 22:512-527.
3. Campbell EA, et al. 2001. Structural mechanism for rifampicin inhibition of bacterial RNA polymerase. Cell 104:901-912.
4. Cole ST. 1996. Rifamycin resistance in mycobacteria. Res. Microbiol. 147:48-52.
5. Cooper AM, Segal BH, Frank AA, Holland SM, Orme IM. 2000. Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice. Infect. Immun. 68:1231-1234.
6. Deaconescu AM, et al. 2006. Structural basis for bacterial transcriptioncoupled DNA repair. Cell 124:507-520.
7. Dove SL, Hochschild A. 2004. A bacterial two-hybrid system based on transcription activation. Methods Mol. Biol. 261:231-246.
8. Dove SL, Joung JK, Hochschild A. 1997. Activation of prokaryotic transcription through arbitrary protein-protein contacts. Nature 386:627-630.
9. 2+to theRNApolymerase active center. Proc. Natl. Acad. Sci. U. S. A. 105:14820-14825.
10. Garcia-Moreno D, et al. 2010. CdnL, a member of the large CarD-like family of bacterial proteins, is vital for Myxococcus xanthus and differs functionally from the global transcriptional regulator CarD. Nucleic Acids Res. 38:4586-4598.
11. Houben EN, Nguyen L, Pieters J. 2006. Interaction of pathogenic mycobacteria with the host immune system. Curr. Opin. Microbiol. 9:76-85.
12. Kaufmann SH. 2002. Protection against tuberculosis: cytokines, T cells, and macrophages. Ann. Rheum. Dis. 61(Suppl. 2):ii54-ii58.
13. Kourout M, et al. 2009. Molecular characterisation of rifampicinresistant Mycobacterium tuberculosis strains from Morocco. Int. J. Tuberc. Lung Dis. 13:1440-1442.
14. Miesel L, Weisbrod TR, Marcinkeviciene JA, Bittman R, Jacobs WR, Jr. 1998 NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis. J. Bacteriol. 180:2459-2467.
15. Nickels BE. 2009. Genetic assays to define and characterize proteinprotein interactions involved in gene regulation. Methods 47:53-62.
16. Ohno H, Koga H, Kohno S, Tashiro T, Hara K. 1996. Relationship between rifampin MICs for and rpoB mutations of Mycobacterium tuberculosis strains isolated in Japan. Antimicrob. Agents Chemother. 40:1053-1056.
17. Pashley CA, Parish T. 2003. Efficient switching of mycobacteriophage L5-based integrating plasmids in Mycobacterium tuberculosis. FEMS Microbiol. Lett. 229:211-215.
18. Pollock JD, et al. 1995. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat. Genet. 9:202-209.
19. Sali A, Blundell TL. 1993. Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234:779-815.
20. Smith AJ, Savery NJ. 2005. RNA polymerase mutants defective in the initiation of transcription-coupled DNA repair. Nucleic Acids Res. 33: 755-764.
21. Stallings CL, Glickman MS. 2010. Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence. Microbes Infect. 12: 1091-1101.
22. Stallings CL, et al. 2009. CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell 138:146-159.
23. Thibodeau SA, Fang R, Joung JK. 2004. High-throughput betagalactosidase assay for bacterial cell-based reporter systems. BioTechniques 36:410-415.
24. Westblade LF, et al. 2010. Structural basis for the bacterial transcriptionrepair coupling factor/RNA polymerase interaction. Nucleic Acids Res. 38:8357-8369.
25. World Health Organization. 2006. Actions for life towards a world free of tuberculosis. World Health Organization, Geneva, Switzerland.
26. World Health Organization. 2010. Global tuberculosis control: a short update to the 2009 report. http://www.who.int/tb/country/en/.