Tumour promoting functions of TGF-β in CML-initiating cells

Journal of Biochemistry

Volumn 152, Issue 5, 2012, Pages 383-385

  Miyazono, Kohei ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Akt; cancer stem cell; CML; MMP 9; TGF

Indexed keywords

BCR ABL PROTEIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMAD PROTEIN; STEM CELL FACTOR; TRANSCRIPTION FACTOR FOXO; TRANSFORMING GROWTH FACTOR BETA;

CANCER GROWTH; CANCER PATIENT; CANCER STEM CELL; CHRONIC MYELOID LEUKEMIA; HEMANGIOBLAST; PHILADELPHIA CHROMOSOME POSITIVE CELL; REVIEW; SIGNAL TRANSDUCTION;

FEMALE; HEMANGIOBLASTS; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MALE; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84868589114     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvs106     Document Type: Review

References (17)

1. Ikushima, H. and Miyazono, K. (2010) TGF-b signalling: a complex web in cancer progression. Nat. Rev. Cancer 10, 415-424
2. Yoshimura, A., Wakabayashi, Y., and Mori, T. (2010) Cellular and molecular basis for the regulation of inflammation by TGF-b. J. Biochem. 147, 781-792
3. Sabe, H. (2011) Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor-b signalling. J. Biochem. 149, 633-639
4. Kawata, M., Koinuma, D., Ogami, T., Umezawa, K., Iwata, C, Watabe, T., and Miyazono, K. (2012) TGF-b-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by proinflammatory cytokines derived from RAW 264.7 macrophage cells. J. Biochem. 151, 205-216
5. Bierie, B. and Moses, H.L. (2006) Tumour microenvir-onment: TGF-b: the molecular Jekyll and Hyde of cancer. Nat. Rev. Cancer 6, 506-520
6. Kim, S.J. and Letterio, J. (2003) Transforming growth factor-b signaling in normal and malignant hematopoi-esis. Leukemia 17, 1731-1737
7. Kurokawa, M., Mitani, K., Irie, K., Matsuyama, T., Takahashi, T., Chiba, S., Yazaki, Y., Matsumoto, K., and Hirai, H. (1998) The oncoprotein Evi-1 represses TGF-b signalling by inhibiting Smad3. Nature 394, 92-96
8. Lee, D.K., Kim, B.C., Brady, J.N., Jeang, K.T., and Kim, S.J. (2002) Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-b signaling by blocking the association of Smad proteins with Smad-binding element. J. Biol. Chem. 277, 33766-33775
9. Arnulf, B., Villemain, A., Nicot, C, Mordelet, E., Charneau, P., Kersual, J., Zermati, Y., Mauviel, A., Bazarbachi, A., and Hermine, O. (2002) Human T-cell lymphotropic virus oncoprotein Tax represses TGF-ß1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood 100, 4129-4138
10. Zhao, T., Satou, Y., Sugata, K., Miyazato, P., Green, P.L., Imamura, T., and Matsuoka, M. (2011) HTLV-1 bZIP factor enhances TGF-ß signaling through p300 coactivator. Blood 118, 1865-1876
11. Zhu, X., Wang, L., Zhang, B., Li, J., Dou, X., and Zhao, R.C. (2011) TGF-ß1-induced PI3K/Akt/NF-KB/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukaemia hemangio-blasts. J. Biochem. 149, 405-414
12. Kaneta, Y., Kagami, Y., Tsunoda, T., Ohno, R., Nakamura, Y., and Katagiri, T. (2003) Genome-wide analysis of gene-expression profiles in chronic myeloid leukemia cells using a cDNA microarray. Int. J. Oncol. 23, 681-691
13. Miyazono, K., Kamiya, Y., and Morikawa, M. (2010) Bone morphogenetic protein receptors and signal transduction. J. Biochem. 147, 35-51
14. Derynck, R. and Zhang, Y.E. (2003) Smad-dependent and Smad-independent pathways in TGF-ß family signalling. Nature 425, 577-584
15. Hasegawa, M., Matsushita, Y., Horikawa, M., Higashi, K., Tomigahara, Y., Kaneko, H., Shirasaki, F., Fujimoto, M., Takehara, K., and Sato, S. (2009) A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis. Arthritis Rheum. 60, 3465-3475
16. Naka, K., Hoshii, T., Muraguchi, T., Tadokoro, Y., Ooshio, T., Kondo, Y., Nakao, S., Motoyama, N., and Hirao, A. (2010) TGF-ß-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature 463, 676-680
17. Naka, K., Hoshii, T., and Hirao, A. (2010) Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells. Cancer Sci. 101, 1577-1581