Optimised chemical synthesis of 5-substituted UDP-sugars and their evaluation as glycosyltransferase inhibitors

Carbohydrate Research

Volumn 364, Issue , 2012, Pages 22-27

  Tedaldi, Lauren M ^a   Pierce, Michael ^b   Wagner, Gerd K ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

5 Iodouridine diphosphosugars; Glycosyltransferase inhibitors; N Methylimidazolium chloride; Pyrophosphate bond; Sugar nucleotides

Indexed keywords

5-IODOURIDINE DIPHOSPHOSUGARS; GLYCOSYL TRANSFERASE; N-METHYLIMIDAZOLIUM CHLORIDE; PYROPHOSPHATE BOND; SUGAR-NUCLEOTIDES;

CHEMICAL BONDS; CHEMICAL REACTIONS; CHLORINE COMPOUNDS; NUCLEOTIDES;

SUGARS;

5 (5 FORMYLTHIEN 2 YL)URIDINE 5' DIPHOSPHATE ALPHA DEXTRO N ACETYLGLUCOSAMINE; 5 FORMYLTHIEN 2 YLBORONIC ACID; 5 IODOURIDINE 5' DIPHOSPHATE ALPHA DEXTRO GALACTOSE; 5 IODOURIDINE 5' DIPHOSPHATE ALPHA DEXTRO N ACETYLGLUCOSAMINE; GLYCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOSE; URIDINE DIPHOSPHATE SUGAR;

AQUEOUS SOLUTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL MODIFICATION; CHO CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROLYSIS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; STOICHIOMETRY; SUBSTITUTION REACTION; SUZUKI MIYAURA CROSS COUPLING; SYNTHESIS;

ANIMALS; CHO CELLS; CRICETINAE; DIPHOSPHATES; ENZYME ACTIVATION; ENZYME ASSAYS; ENZYME INHIBITORS; GALACTOSEPHOSPHATES; MAGNETIC RESONANCE SPECTROSCOPY; N-ACETYLGLUCOSAMINYLTRANSFERASES; RECOMBINANT PROTEINS; SOLVENTS; TETRAZOLES; TIME FACTORS; URIDINE DIPHOSPHATE; URIDINE DIPHOSPHATE GALACTOSE; URIDINE DIPHOSPHATE N-ACETYLGLUCOSAMINE;

EID: 84868567618     PISSN: 00086215     EISSN: 1873426X     Source Type: Journal    
DOI: 10.1016/j.carres.2012.10.009     Document Type: Article

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