NCX1 is a new rest target gene: Role in cerebral ischemia

Neurobiology of Disease

Volumn 50, Issue 1, 2013, Pages 76-85

  Formisano, Luigi ^a,b   Guida, Natascia ^a,c   Valsecchi, Valeria ^a   Pignataro, Giuseppe ^a   Vinciguerra, Antonio ^a   Pannaccione, Anna ^a   Secondo, Agnese ^a   Boscia, Francesca ^a   Molinaro, Pasquale ^a   Sisalli, Maria Jose ^a   Sirabella, Rossana ^c   Casamassa, Antonella ^a   Canzoniero, Lorella M T ^a,b   Di Renzo, Gianfranco ^a   Annunziato, Lucio ^a,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SANNIO   (Italy)

^c IRCCS SDN   (Italy)

Author keywords

Acetylation; Epigenetic; NCX1; REST; Stroke

Indexed keywords

GLUCOSE; HISTONE H4; OXYGEN; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; SMALL INTERFERING RNA; SODIUM CALCIUM EXCHANGE PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SIN3A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN SLICE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DEACETYLATION; GENE; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; HIPPOCAMPUS; HUMAN; HUMAN CELL; MIDDLE CEREBRAL ARTERY OCCLUSION; NCX1 GENE; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REOXYGENATION; SITE DIRECTED MUTAGENESIS;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; BRAIN ISCHEMIA; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURONS; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; SODIUM-CALCIUM EXCHANGER; TRANSFECTION;

EID: 84868564151     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.10.010     Document Type: Article

References (36)

1. Annunziato L., et al. Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol. Rev. 2004, 56:633-654.
2. Ballas N., Mandel G. The many faces of REST oversee epigenetic programming of neuronal genes. Curr. Opin. Neurobiol. 2005, 15:500-506.
3. Boscia F., et al. Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. J. Cereb. Blood Flow Metab. 2006, 26:502-517.
4. Boscia F., et al. NCX1 expression and functional activity increase in microglia invading the infarct core. Stroke 2009, 40:3608-3617.
5. Buckley N.J., et al. The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease. Neurobiol. Dis. 2010, 39:28-39.
6. Calderone A., et al. Ischemic insults derepress the gene silencer REST in neurons destined to die. J. Neurosci. 2003, 23:2112-2121.
7. Chandrasekaran S., et al. Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. FASEB J. 2009, 23:3851-3864.
8. Cuomo O., et al. A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage. J. Neurosci. 2008, 28:2053-2063.
9. Formisano L., et al. Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:4170-4175.
10. Formisano L., et al. The two isoforms of the Na+/Ca2+ exchanger, NCX1 and NCX3, constitute novel additional targets for the prosurvival action of Akt/protein kinase B pathway. Mol. Pharmacol. 2008, 73:727-737.
11. Formisano L., et al. The repressor element 1-silencing transcription factor is a novel molecular target for the neurotoxic effect of the polychlorinated biphenyl mixture aroclor 1254 in neuroblastoma SH-SY5Y cells. J. Pharmacol. Exp. Ther. 2011, 338:997-1003.
12. Johnson R., et al. REST regulates distinct transcriptional networks in embryonic and neural stem cells. PLoS Biol. 2008, 6:e256.
13. Johnson R., et al. Evolution of the vertebrate gene regulatory network controlled by the transcriptional repressor REST. Mol. Biol. Evol. 2009, 26:1491-1507.
14. Johnson R., et al. A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes. PLoS Genet. 2012, 8:e1002624.
15. Kim C., et al. Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene. J. Biol. Chem. 2004, 279:46464-46473.
16. Kuratomi S., et al. NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes. Biochem. Biophys. Res. Commun. 2007, 353:67-73.
17. Lee S.L., et al. Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms. J. Biol. Chem. 1994, 269:14849-14852.
18. Li Y., et al. Regulatory role of neuron-restrictive silencing factor in the specific expression of cocaine- and amphetamine-regulated transcript gene. J. Neurochem. 2008, 106:1314-1324.
19. Molinaro P., et al. Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. J. Neurosci. 2008, 28:1179-1184.
20. Mucha M., et al. Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability. J. Neurosci. 2010, 30:13235-13245.
21. Noh K.M., et al. Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E962-E971.
22. Ooi L., Wood I. Chromatin crosstalk in development and disease: lessons from REST. Nat. Rev. Genet. 2007, 8:544-554.
23. Otto S., et al. A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. J. Neurosci. 2007, 27:6729-6739.
24. Perissi V., et al. Deconstructing repression: evolving models of co-repressor action. Nat. Rev. Genet. 2010, 11:109-123.
25. Pignataro G., et al. Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke 2004, 35:2566-2570.
26. Pignataro G., et al. NCX1 and NCX3: two new effectors of delayed preconditioning in brain ischemia. Neurobiol. Dis. 2011, 45:616-623.
27. Plaisance V., et al. The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1. J. Biol. Chem. 2005, 280:401-407.
28. Reddy S.D., et al. Multiple coregulatory control of tyrosine hydroxylase gene transcription. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:4200-4205.
29. Renthal W., et al. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 2007, 56:517-529.
30. Schoenherr C.J., et al. Identification of potential target genes for the neuron-restrictive silencer factor. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:9881-9886.
31. Scorziello A., et al. NO-induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn-SOD activity and expression via Ras/ERK1/2 pathway. J. Neurochem. 2007, 103:1472-1480.
32. Secondo A., et al. The Na+/Ca2+ exchanger isoform 3 (NCX3) but not isoform 2 (NCX2) and 1 (NCX1) singly transfected in BHK cells plays a protective role in a model of in vitro hypoxia. Ann. N. Y. Acad. Sci. 2007, 1099:481-485.
33. Sirabella R., et al. Anoxia-induced NF-kappaB-dependent upregulation of NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons. Stroke 2009, 40:922-929.
34. Sirabella R., et al. ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na(+)/Ca(2+) exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells. J. Neurochem. 2012, 122:911-922.
35. Valsecchi V., et al. NCX1 Is a Novel Target Gene for Hypoxia-Inducible Factor-1 in Ischemic Brain Preconditioning. Stroke 2011, 42:754-763.
36. Xu M., et al. NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes. Mol. Cell. Biol. 2008, 28:4819-4828.