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Volumn 15, Issue 11, 2012, Pages 984-991

Anti-Inflammatory and Anti-Ulcer Activities of Carvacrol, a Monoterpene Present in the Essential Oil of Oregano

Author keywords

anti inflammatory; anti ulcer; carvacrol; ear edema; essential oil; healing; monoterpene; natural product; paw edema

Indexed keywords

ACETIC ACID; ARACHIDONIC ACID; CARVACROL; DEXTRAN; ESSENTIAL OIL; HISTAMINE; INDOMETACIN; MYRISTIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; RUTHENIUM RED; SUBSTANCE P;

EID: 84868558937     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.0102     Document Type: Article
Times cited : (121)

References (47)
  • 1
    • 0035080283 scopus 로고    scopus 로고
    • Hemato-logical studies on black cumin oil from the seeds of Nigella sativa L
    • Enomoto S, Asano R, Iwahori Y, Narui T, Okada Y: Hemato-logical studies on black cumin oil from the seeds of Nigella sativa L. Biol Pharm Bull 2001;24:307-310.
    • (2001) Biol Pharm Bull , vol.24 , pp. 307-310
    • Enomoto, S.1    Asano, R.2    Iwahori, Y.3    Narui, T.4    Okada, Y.5
  • 2
    • 14044257070 scopus 로고    scopus 로고
    • Phytochemical analysis and in vitro antimicrobial activity of two Satureja species essential oils
    • Skocibusic M, Besic N: Phytochemical analysis and in vitro antimicrobial activity of two Satureja species essential oils. Phytother Res 2004;18:967-970.
    • (2004) Phytother Res , vol.18 , pp. 967-970
    • Skocibusic, M.1    Besic, N.2
  • 6
    • 33947600169 scopus 로고    scopus 로고
    • In vitro acetyl-cholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone
    • Jukic M, Politeo O, Maksimovic M, Milos M: In vitro acetyl-cholinesterase inhibitory properties of thymol, carvacrol and their derivatives thymoquinone and thymohydroquinone. Phytother Res 2007;21:259-261.
    • (2007) Phytother Res , vol.21 , pp. 259-261
    • Jukic, M.1    Politeo, O.2    Maksimovic, M.3    Milos, M.4
  • 7
    • 73149086389 scopus 로고    scopus 로고
    • Carvacrol, a component of thyme oil, activates PPARa and c and suppresses COX-2 expression
    • Hotta M, Nakata R, Katsukawa M, Hori K, Takahashi S, Inoue H: Carvacrol, a component of thyme oil, activates PPARa and c and suppresses COX-2 expression. J Lipid Res 2010;51:132-139.
    • (2010) J Lipid Res , vol.51 , pp. 132-139
    • Hotta, M.1    Nakata, R.2    Katsukawa, M.3    Hori, K.4    Takahashi, S.5    Inoue, H.6
  • 8
    • 0141685904 scopus 로고    scopus 로고
    • Effect of dietary supplementation with oregano essential oil on performance of broilers after experimental infection with Eimeria tenella
    • Giannenas I, Florou-Paneri P, Papazahariadou M, Christaki E, Botsoglou NA, Spais AB: Effect of dietary supplementation with oregano essential oil on performance of broilers after experimental infection with Eimeria tenella. Arch Anim Nutr 2003;57:99-106.
    • (2003) Arch Anim Nutr , vol.57 , pp. 99-106
    • Giannenas, I.1    Florou-Paneri, P.2    Papazahariadou, M.3    Christaki, E.4    Botsoglou, N.A.5    Spais, A.B.6
  • 9
    • 84855503134 scopus 로고    scopus 로고
    • Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet
    • Cho S, Choi Y, Park S, Park T: Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet. J Nutr Biochem 2012;23:192-201.
    • (2012) J Nutr Biochem , vol.23 , pp. 192-201
    • Cho, S.1    Choi, Y.2    Park, S.3    Park, T.4
  • 10
    • 0022616439 scopus 로고
    • In vitro inhibition of prosta-glandin biosynthesis by essential oils and phenolic compounds
    • Wagner H, Wierer M, Bauer R: In vitro inhibition of prosta-glandin biosynthesis by essential oils and phenolic compounds. Planta Med 1986;52:184-187.
    • (1986) Planta Med , vol.52 , pp. 184-187
    • Wagner, H.1    Wierer, M.2    Bauer, R.3
  • 11
    • 59449101301 scopus 로고    scopus 로고
    • In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesis
    • Landa P, Kokoska L, Pribylova M, Vanek T, Marsik P: In vitro anti-inflammatory activity of carvacrol: inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesis. Arch Pharm Res 2009;32:75-78.
    • (2009) Arch Pharm Res , vol.32 , pp. 75-78
    • Landa, P.1    Kokoska, L.2    Pribylova, M.3    Vanek, T.4    Marsik, P.5
  • 12
    • 67249094291 scopus 로고
    • Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs
    • Winter CA, Risley EA, Nuss GW: Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 1962;111:544-547.
    • (1962) Proc Soc Exp Biol Med , vol.111 , pp. 544-547
    • Winter, C.A.1    Risley, E.A.2    Nuss, G.W.3
  • 13
    • 24944522851 scopus 로고    scopus 로고
    • Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus
    • Kassuya CA, Leite DF, De Melo LV, Rehder VL, Calixto JB: Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus. Planta Med 2005;71:721-726.
    • (2005) Planta Med , vol.71 , pp. 721-726
    • Kassuya, C.A.1    Leite, D.F.2    De Melo, L.V.3    Rehder, V.L.4    Calixto, J.B.5
  • 16
    • 0015023481 scopus 로고
    • Method of experimental penetrating gastric and duodenal ulcers in rats
    • Okabe S, Roth LA, Pfeier JA: Method of experimental penetrating gastric and duodenal ulcers in rats. Am J Dig Dis 1971;16:277-280.
    • (1971) Am J Dig Dis , vol.16 , pp. 277-280
    • Okabe, S.1    Roth, L.A.2    Pfeier, J.A.3
  • 17
    • 65649109750 scopus 로고    scopus 로고
    • Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer
    • Rios JL, Recio MC, Escandell JM, Andujar I: Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer. Curr Pharm Des 2009;15:1212-1237.
    • (2009) Curr Pharm des , vol.15 , pp. 1212-1237
    • Rios, J.L.1    Recio, M.C.2    Escandell, J.M.3    Andujar, I.4
  • 19
    • 81555217983 scopus 로고    scopus 로고
    • Analgesic and antiinflammatory activities of the aqueous extract from Plectranthus amboinicus (Lour.) Spreng. both in vitro and in vivo
    • Chiu YJ, Huang TH, Chiu CS, Lu TC, Chen YW, Peng WH, Chen CY: Analgesic and antiinflammatory activities of the aqueous extract from Plectranthus amboinicus (Lour.) Spreng. both in vitro and in vivo. Evid Based Complement Alternat Med 2012;2012:508137.
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 508137
    • Chiu, Y.J.1    Huang, T.H.2    Chiu, C.S.3    Lu, T.C.4    Chen, Y.W.5    Peng, W.H.6    Chen, C.Y.7
  • 24
    • 16344369236 scopus 로고    scopus 로고
    • Extracts and constituents of Lavandula multifida with topical anti-inflammatory activity
    • Sosa S, Altinier G, Politi M, Bracab A, Morelli I, Loggiaa RD: Extracts and constituents of Lavandula multifida with topical anti-inflammatory activity. Phytomedicine 2005;12:271-277.
    • (2005) Phytomedicine , vol.12 , pp. 271-277
    • Sosa, S.1    Altinier, G.2    Politi, M.3    Bracab, A.4    Morelli, I.5    Loggiaa, R.D.6
  • 25
    • 0032889943 scopus 로고    scopus 로고
    • Anti-oxidant activity and mechanism of action of thymol and carva-crol in two lipid systems
    • Yanishlieva N, Marinova EM, Gordon MH, Raneva VG: Anti-oxidant activity and mechanism of action of thymol and carva-crol in two lipid systems. Food Chem 1999;64:59-66.
    • (1999) Food Chem , vol.64 , pp. 59-66
    • Yanishlieva, N.1    Marinova, E.M.2    Gordon, M.H.3    Raneva, V.G.4
  • 27
    • 29244433730 scopus 로고    scopus 로고
    • Linalool inhibits in vitro NO formation: Probable involvement in the anti-nociceptive activity of this monoterpene compound
    • Peana AT, Marzocco S, Popolo A, Pinto A: Linalool inhibits in vitro NO formation: probable involvement in the anti-nociceptive activity of this monoterpene compound. Life Sci 2006;78:719-723.
    • (2006) Life Sci , vol.78 , pp. 719-723
    • Peana, A.T.1    Marzocco, S.2    Popolo, A.3    Pinto, A.4
  • 32
    • 33846007707 scopus 로고    scopus 로고
    • Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea
    • Andrade SF, Cardoso LGV, Carvalho JCT, Bastos JK: Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea. J Ethnopharmacol 2007;109:464-471.
    • (2007) J Ethnopharmacol , vol.109 , pp. 464-471
    • Andrade, S.F.1    Cardoso, L.G.V.2    Carvalho, J.C.T.3    Bastos, J.K.4
  • 33
    • 0033830198 scopus 로고    scopus 로고
    • Pain: Molecular mechanisms
    • Costigan M, Woolf CJ: Pain: molecular mechanisms. J Pain 2000;1:35-44.
    • (2000) J Pain , vol.1 , pp. 35-44
    • Costigan, M.1    Woolf, C.J.2
  • 34
    • 0035855860 scopus 로고    scopus 로고
    • Molecular mechanisms of nociception
    • Julius D, Basbaum AI: Molecular mechanisms of nociception. Nature 2001;413:203-210.
    • (2001) Nature , vol.413 , pp. 203-210
    • Julius, D.1    Basbaum, A.I.2
  • 36
    • 0027377233 scopus 로고
    • Comparative evaluation of arachidonic acid (AA)-and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation
    • Rao TS, Currie JL, Shaffer AF, Isakson PC: Comparative evaluation of arachidonic acid (AA)-and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation. Inflammation 1993;17:723-741.
    • (1993) Inflammation , vol.17 , pp. 723-741
    • Rao, T.S.1    Currie, J.L.2    Shaffer, A.F.3    Isakson, P.C.4
  • 37
    • 0025602534 scopus 로고
    • The conversion stage of skin carci-nogenesis
    • Marks F, Fürstenberger G: The conversion stage of skin carci-nogenesis. Carcinogenesis 1990;11:2085-2092.
    • (1990) Carcinogenesis , vol.11 , pp. 2085-2092
    • Marks, F.1    Fürstenberger, G.2
  • 38
    • 0027931085 scopus 로고
    • Protective effects of papavarine salicylate in mouse ear dermatitis and PAF-induced rat paw edema
    • De Bernardis L, Leonardi G, Caruso A, Cutuli VM, Arnico-Roxas M: Protective effects of papavarine salicylate in mouse ear dermatitis and PAF-induced rat paw edema. Agents Actions 1994;42:29-33.
    • (1994) Agents Actions , vol.42 , pp. 29-33
    • De Bernardis, L.1    Leonardi, G.2    Caruso, A.3    Cutuli, V.M.4    Arnico-Roxas, M.5
  • 39
    • 40249098499 scopus 로고    scopus 로고
    • Anti-inflammatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae)
    • Rodrigues SD, Baroni S, Svidzinski AE, Bersanizamado CA, Cortez DA: Anti-inflammatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae). J Ethnopharmacol 2008;116:569-573.
    • (2008) J Ethnopharmacol , vol.116 , pp. 569-573
    • Rodrigues, S.D.1    Baroni, S.2    Svidzinski, A.E.3    Bersanizamado, C.A.4    Cortez, D.A.5
  • 41
    • 70349289078 scopus 로고    scopus 로고
    • The arachidonic acid effect on platelet nitric oxide level
    • Signorello MG, Segantin A, Leoncini G: The arachidonic acid effect on platelet nitric oxide level. Biochim Biophys Acta 2009;1791:1084-1092.
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 1084-1092
    • Signorello, M.G.1    Segantin, A.2    Leoncini, G.3
  • 42
    • 77950521849 scopus 로고    scopus 로고
    • A novel heat-shock protein coinducer boosts stress protein hsp70 to activate t cell regulation of inflammation in autoimmune arthritis
    • Wieten L, Zee RVD, Spiering R, Wagenaar-Hilbers J, Kooten PV, Broere F, Eden WV: A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis. Arthritis Rheum 2010;62:1026-1035.
    • (2010) Arthritis Rheum , vol.62 , pp. 1026-1035
    • Wieten, L.1    Zee, R.V.D.2    Spiering, R.3    Wagenaar-Hilbers, J.4    Kooten, P.V.5    Broere, F.6    Eden, W.V.7
  • 43
    • 55149118928 scopus 로고    scopus 로고
    • Aegiceras corniculatum extract suppresses initial and late phases of inflammation in rat paw and attenuates the production of eicosa-noids in rat neutrophils and human platelets
    • Roome T, Dar A, Naqvi S, Ali S, Choudhary MI: Aegiceras corniculatum extract suppresses initial and late phases of inflammation in rat paw and attenuates the production of eicosa-noids in rat neutrophils and human platelets. J Ethnopharmacol 2008;120:248-254.
    • (2008) J Ethnopharmacol , vol.120 , pp. 248-254
    • Roome, T.1    Dar, A.2    Naqvi, S.3    Ali, S.4    Choudhary, M.I.5
  • 44
    • 0003984159 scopus 로고
    • Produtos naturais: Alternativa segura?
    • Secco RS: Produtos naturais: alternativa segura? Cienc Cult 1990;42:807-810.
    • (1990) Cienc Cult , vol.42 , pp. 807-810
    • Secco, R.S.1
  • 45
    • 25644437787 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of gastrointestinal ulcer healing
    • Tarnawski AS: Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 2005;50:24-33.
    • (2005) Dig Dis Sci , vol.50 , pp. 24-33
    • Tarnawski, A.S.1
  • 46
    • 55949135789 scopus 로고    scopus 로고
    • Prostaglandins, NSAIDs, and gastric mucosal protection: Why doesn't the stomach digest itself?
    • Wallace JL: Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? Physiol Rev 2008;88:1547-1565.
    • (2008) Physiol Rev , vol.88 , pp. 1547-1565
    • Wallace, J.L.1
  • 47
    • 25844492001 scopus 로고    scopus 로고
    • An overview of acetic acid ulcer models: The history and state of the art of peptic ulcer research
    • Okabe S, Amagase K: An overview of acetic acid ulcer models: the history and state of the art of peptic ulcer research. Biol Pharm Bull 2005;28:1321-1341.
    • (2005) Biol Pharm Bull , vol.28 , pp. 1321-1341
    • Okabe, S.1    Amagase, K.2


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