Hypoglycemia-induced increases in thalamic cerebral blood flow are blunted in subjects with type 1 diabetes and hypoglycemia unawareness

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 11, 2012, Pages 2084-2090

  Mangia, Silvia ^a   Tesfaye, Nolawit ^a   De Martino, Federico ^a,b   Kumar, Anjali F ^a   Kollasch, Pete ^a   Moheet, Amir A ^a   Eberly, Lynn E ^c   Seaquist, Elizabeth R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

diabetes; glucose; hypoglycemia; imaging

Indexed keywords

ADRENALIN; GLUCAGON; GLUCOSE; HEMOGLOBIN A1C;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; AWARENESS; BODY MASS; BRAIN BLOOD FLOW; BRAIN REGION; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HORMONAL REGULATION; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MESENCEPHALON; NEUROMODULATION; PRIORITY JOURNAL; REGULATORY MECHANISM; SPIN LABELING; THALAMUS;

ADOLESCENT; ADULT; AGED; AWARENESS; BLOOD GLUCOSE; CEREBROVASCULAR CIRCULATION; DIABETES MELLITUS, TYPE 1; EPINEPHRINE; FEMALE; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; HORMONES; HUMANS; HYPOGLYCEMIA; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; THALAMUS; YOUNG ADULT;

EID: 84868553427     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.117     Document Type: Article

References (17)

1. Teves D, Videen TO, Cryer PE, Powers WJ. Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia. Proc Natl Acad Sci USA 2004; 101: 6217-6221. (Pubitemid 38520554)
2. Musen G, Simonson DC, Bolo NR, Driscoll A, Weinger K, Raji A, Theberge J, Renshaw PF, Jacobson AM. Regional brain activation during hypoglycemia in type 1 diabetes. J Clin Endocrinol Metab 2008; 93: 1450-1457. (Pubitemid 351519747)
3. Page KA, Arora J, Qiu M, Relwani R, Constable RT, Sherwin RS. Small decrements in systemic glucose provoke increases in hypothalamic blood flow prior to the release of counterregulatory hormones. Diabetes 2009; 58: 448-452.
4. Teh MM, Dunn JT, Choudhary P, Samarasinghe Y, Macdonald I, O'Doherty M, Marsden P, Reed LJ, Amiel SA. Evolution and resolution of human brain perfusion responses to the stress of induced hypoglycemia. Neuroimage 2010; 53: 584-592.
5. Cryer PE. Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 2005; 54: 3592-3601. (Pubitemid 43334356)
6. Dunn JT, Cranston I, Marsden PK, Amiel SA, Reed LJ. Attenuation of amydgala and frontal cortical responses to low blood glucose concentration in asymptomatic hypoglycemia in type 1 diabetes: a new player in hypoglycemia unawareness? Diabetes 2007; 56: 2766-2773. (Pubitemid 350044920)
7. Arbelaez AM, Powers WJ, Videen TO, Price JL, Cryer PE. Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure. Diabetes 2008; 57: 470-475.
8. Chen JJ, Wieckowska M, Meyer E, Pike GB. Cerebral blood flow measurement using fMRI and PET: a cross-validation study. Int J Biomed Imaging 2008; 516359.
9. Clarke WL, Cox DJ, Gonder-Frederick LA, Julian D, Schlundt D, Polonsky W. Reduced awareness of hypoglycemia in adults with IDDM. A prospective study of hypoglycemic frequency and associated symptoms. Diabetes Care 1995; 18: 517-522.
10. Luh WM, Wong EC, Bandettini PA, Hyde JS. QUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling. Magn Reson Med 1999; 41: 1246-1254. (Pubitemid 29247294)
11. Seaquist ER. Comparison of arterialized venous sampling from the hand and foot in the assessment of in vivo glucose metabolism. Metabolism 1997; 46: 1364-1366. (Pubitemid 27473525)
12. Bingham EM, Dunn JT, Smith D, Sutcliffe-Goulden J, Reed LJ, Marsden PK, Amiel SA. Differential changes in brain glucose metabolism during hypoglycaemia accompany loss of hypoglycaemia awareness in men with type 1 diabetes mellitus. An [11C]-3-O-methyl-D-glucose PET study. Diabetologia 2005; 48: 2080-2089. (Pubitemid 41416920)
13. Kodl CT, Franc DT, Rao JP, Anderson FS, Thomas W, Mueller BA, Lim KO, Seaquist ER. Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function. Diabetes 2008; 57: 3083-3089.
14. Newman J. Thalamic contributions to attention and consciousness. Conscious Cogn 1995; 4: 172-193.
15. Steriade M, Llinas RR. The functional states of the thalamus and the associated neuronal interplay. Physiol Rev 1988; 68: 649-742.
16. Flanagan DE, Keshavarz T, Evans ML, Flanagan S, Fan X, Jacob RJ, Sherwin RS. Role of corticotrophin-releasing hormone in the impairment of counterregulatory responses to hypoglycemia. Diabetes 2003; 52: 605-613. (Pubitemid 36323565)
17. Segel SA, Fanelli CG, Dence CS, Markham J, Videen TO, Paramore DS, Powers WJ, Cryer PE. Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia. Diabetes 2001; 50: 1911-1917. (Pubitemid 33641613)