Stichoposide C induces apoptosis through the generation of ceramide in leukemia and colorectal cancer cells and shows in vivo antitumor activity

Clinical Cancer Research

Volumn 18, Issue 21, 2012, Pages 5934-5948

  Yun, Seong Hoon ^a   Park, Eun Seon ^a   Shin, Sung Won ^a   Na, Yong Woo ^a   Han, Jin Yeong ^a   Jeong, Jin Sook ^a   Shastina, Valeria V ^b   Stonik, Valentin A ^b   Park, Joo In ^a   Kwak, Jong Young ^a  

^a Dong A University College of Medicine   (South Korea)

^b PACIFIC INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; CASPASE 8; CERAMIDE; DESIPRAMINE; FAS ANTIGEN; PROTEIN BID; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; STICHOPOSIDE C; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; COLORECTAL CANCER; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; DRUG DETERMINATION; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEA CUCUMBER; SIGNAL TRANSDUCTION; THELENOTA ANAX; TREATMENT RESPONSE;

ANIMALS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 8; CELL LINE, TUMOR; CERAMIDES; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; GLUTATHIONE; GLYCOSIDES; HL-60 CELLS; HUMANS; LEUKEMIA; MICE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; TRITERPENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84868541040     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-0655     Document Type: Article

References (38)

1. Smith M, Barnett M, Bassan R, Gatta G, Tondini C, Kern W. Adult acute myeloid leukemia. Crit Rev Oncol Hematol 2004;50:197-222.
2. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, et al. Cancer statistics. CA Cancer J Clin 2004;54:8-29.
3. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA Cancer J Clin 2005;55:74-108. (Pubitemid 40372904)
4. Water J, Cunningham D. The changing face of chemotherapy in colorectal cancer. Br J Cancer 2000;84:1-7.
5. Stonik VA, Kalinin VI, Avilov SA. Toxins from sea cucumbers (holothuroids): chemical structures, properties, taxonomic distribution, biosynthesis and evolution. J Nat Toxins 1999;8:235-48. (Pubitemid 29306122)
6. Stonik VA. Some terpenoid and steroid derivatives from echinoderms and sponges. Pure Appl Chem 1986;58:423-36.
7. Kalinin VI, Aminin DL, Avilov SA, Silchenko AS, Stonik VA. Triterpene glycosides from sea cucumbers (Holothuriodea, Echinodermata). Biological activities and functions. In: Atta-ur-Rahman, editor. Studies in natural products chemistry. Vol. 35, London, UK: Elsevier Science BV; 2008. p. 135-96.
8. Stonik VA, Maltsev II, Kalinovsky AI, Conde K, Elyakov GB. Glycosides of marine- invertebrates. XI. The two novel triterpene glycosides from holothorian of Stichopodidae family. Chem Nat Prod 1982;194-9.
9. 2 from the sea cucumber Stichopus chloronotus (Brandt). Chem Phar Bull 1981;29:2387-91.
10. Stonik VA, Maltsev II, Elyakov GB. Structures of thelenotoside-A and thelenoside-B from the sea cucumber Thelenota ananas . Chem Nat Prod 1982;624-7.
11. Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004;4:604-16. (Pubitemid 39025055)
12. Brown DA, London E. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 1998;14:111-36. (Pubitemid 29001451)
13. Kolesnick RN, Goni FM, Alonso A. Compartmentalization of ceramide signaling: physical foundations and biological effects. J Cell Physiol 2000;184:285-300. (Pubitemid 30625491)
14. Hannun YA, Obeid LM. Principles of bioactive lipid signaling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008;9:139-50. (Pubitemid 351158911)
15. Strum JC, Ghosh S, Bell RM. Lipid second messengers. A role in cell growth regulation and cell cycle regulation. Adv Exp Mol Biol 1997;407:421-31.
16. Goni FM, Alonso A. Sphingomyelinases: enzymology and membrane activity. FEBS Lett 2002;531:38-46. (Pubitemid 35232782)
17. Gulbins E, Kolesnick R. Acid sphingomyelinase-derived ceramide signaling in apoptosis. Subcell Biochem 2002;36:229-44.
18. Levade T, Jaffrezou JP. Signalling sphingomyelinases: which, where, how and why?Biochim Biophys Acta 1999;1438:1-17.
19. Taha TA, Mullen TD, Obeid LM. A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta 2006;1758:2027-36.
20. Lee CJ, Han JS, Seo CY, Park TH, Kwon HC, Jeong JS, et al. Pioglitazone, a synthetic ligand for PPARγ, induces apoptosis in RB-deficient human colorectal cancer cells. Apoptosis 2006;11:401-11.
21. 2 induces apoptosis by reactive oxygen species-mediated inactivation of Akt in leukemia and colorectal cancer cells and shows in vivo antitumor activity. Clin Cancer Res 2009;15:5414-25.
22. 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. Apoptosis 2007;12:2101-14.
23. Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006;25:4798-811. (Pubitemid 44187627)
24. Green D, Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 1998;8:267-71. (Pubitemid 28310224)
25. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-12. (Pubitemid 28406816)
26. Dbaibo GS, El-Assaad W, Krikorian A, Liu B, Diab K, Idriss NZ, et al. Ceramide generation by two distinct pathways in tumor necrosis factor α-induced cell death. FEBS Lett 2001;503:7-12. (Pubitemid 32769946)
27. Grassme H, Cremesti A, Kolesnick R, Gulbins E. Ceramide-mediated clustering is required for CD95-DISC formation. Oncogene 2003;22:5457-70. (Pubitemid 37072201)
28. Grassme H, Jekle A, Riehle A, Schwartz H, Berger J, Sandhoff K, et al. CD95 signaling via ceramide-rich membrane rafts. J Biol Chem 2001;276:20589-96.
29. Grassme H, Jendrossek V, Bock J, Riehle A, Gulbins E. Ceramide-rich membrane rafts mediate CD40 clustering. J Immunol 2002;168:298-307. (Pubitemid 34014130)
30. Lacour S, Hammann A, Grazide S, Lagadic-Gossmann D, Athias A, Sergent O, et al. Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells. Cancer Res 2004;64:3593-8. (Pubitemid 38657937)
31. Liu X, Zeidan Y, Elojeimy S, Holman DH, El-Zawahry AM, Guo GW, et al. Involvement of sphingolipids in apoptin-induced cell killing. Mol Ther 2006;14:627-36. (Pubitemid 44480757)
32. Liu B, Hannun YA. Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem 1997;272:16281-7. (Pubitemid 27276449)
33. Pettit GR, Herald CL, Herald DL. Antineoplastic agents XLV: sea cucumber cytotoxic saponins. J Pharm Sci 1976;65:1558-9.
34. Hannun YA. Functions of ceramide coordinating cellular responses to stress. Science 1996;274:1855-9. (Pubitemid 26424756)
35. Grassme H, Schwarz H, Gulbins E. Molecular mechanisms of ceramide-mediated CD95 clustering. Biochem Biophys Res Commun 2001;284:1016-30. (Pubitemid 32924751)
36. Sawada M, Nakashima S, Kiyono T, Yamada J, Hara S, Nakagawa M, et al. Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells. Exp Cell Res 2002;273:157-68. (Pubitemid 34920666)
37. Liu B, Andrieu-Abadie N, Levade T, Zhang P, Obeid LM, Hannun YA. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death. J Biol Chem 1998;273:11313-20. (Pubitemid 28204985)
38. van den Dobbelsteen DJ, NobelCS, Schlegel J, Cotgreave IA, Orrenius S, Slater AF. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J Biol Chem 1996; 271:15420-7. (Pubitemid 26225311)