Positive histological inflammatory margins are associated with increased risk for intra-abdominal septic complications in patients undergoing ileocolic resection for crohn's disease

Diseases of the Colon and Rectum

Volumn 55, Issue 11, 2012, Pages 1125-1130

  Shental, Omri ^a   Tulchinsky, Hagit ^a   Greenberg, Ron ^a   Klausner, Joseph M ^a   Avital, Shmuel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Anastomotic leakage; Crohn's disease; Ileocecectomy; Ileocolic resection; Postoperative septic complications

Indexed keywords

STEROID;

ABDOMEN; ABDOMINAL ABSCESS; ADULT; ANASTOMOSIS LEAKAGE; ARTICLE; CROHN DISEASE; DISEASE COURSE; DISEASE DURATION; EMERGENCY SURGERY; ENTEROCUTANEOUS FISTULA; FEMALE; FROZEN SECTION; HISTOLOGY; HISTOPATHOLOGY; HUMAN; ILEUM RESECTION; INFLAMMATION; LAPAROSCOPIC SURGERY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PERCUTANEOUS DRAINAGE; POSTOPERATIVE PERIOD; RISK FACTOR; SEPSIS; SIGMOIDECTOMY; STEROID THERAPY; STROMA; TREATMENT OUTCOME;

ABDOMINAL ABSCESS; ADULT; ANASTOMOSIS, SURGICAL; ANASTOMOTIC LEAK; COLECTOMY; COLON; COLON, SIGMOID; CONFIDENCE INTERVALS; CROHN DISEASE; CUTANEOUS FISTULA; FEMALE; HUMANS; ILEUM; INFLAMMATION; INTESTINAL FISTULA; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; YOUNG ADULT;

EID: 84868538536     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1097/DCR.0b013e318267c74c     Document Type: Article

References (22)

1. Bernell O, Lapidus A, Hellers G. Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease. Br J Surg. 2000;87:1697-1701.
2. Gardiner KR, Dasari BV. Operative management of small bowel Crohn's disease. Surg Clin North Am. 2007;87:587-610.
3. Bernell O, Lapidus A, Hellers G. Risk factors for surgery and postoperative recurrence in Crohn's disease. Ann Surg. 2000;231:38-45.
4. Krupnick AS, Morris JB. The long-term results of resection and multiple resections in Crohn's disease. Semin Gastrointest Dis. 2000;11:41-51.
5. Heimann TM, Greenstein AJ, Lewis B, Kaufman D, Heimann DM, Aufses AH Jr. Comparison of primary and reoperative surgery in patients with Crohns disease. Ann Surg. 1998;227:492-495.
6. Fazio VW, Marchetti F, Church M, et al. Effect of resection margins on the recurrence of Crohn's disease in the small bowel: A randomized controlled trial. Ann Surg. 1996;224:563-571.
7. Lautenbach E, Berlin JA, Lichtenstein GR. Risk factors for early postoperative recurrence of Crohn's disease. Gastroenterology. 1998;115:259-267.
8. Subramanian V, Pollok RC, Kang JY, Kumar D. Systematic review of postoperative complications in patients with inflammatory bowel disease treated with immunomodulators. Br J Surg. 2006;93:793-799.
9. Alves A, Panis Y, Bouhnik Y, Pocard M, Vicaut E, Valleur P. Risk factors for intra-abdominal septic complications after a first ileocecal resection for Crohn's disease: A multivariate analysis in 161 consecutive patients. Dis Colon Rectum. 2007;50:331-336.
10. Yamamoto T, Allan RN, Keighley MR. Risk factors for intra-abdominal sepsis after surgery in Crohn's disease. Dis Colon Rectum. 2000;43:1141-1145.
11. Tay GS, Binion DG, Eastwood D, Otterson MF. Multivariate analysis suggests improved perioperative outcome in Crohn's disease patients receiving immunomodulator therapy after segmental resection and/or strictureplasty. Surgery. 2003;134:565-572.
12. Iesalnieks I, Kilger A, Glass H, et al. Intraabdominal septic complications following bowel resection for Crohn's disease: Detrimental influence on long-term outcome. Int J Colorectal Dis. 2008;23:1167-1174.
13. Penner RM, Madsen KL, Fedorak RN. Postoperative Crohn's disease. Inflamm Bowel Dis. 2005;11:765-777.
14. Dietz DW, Laureti S, Strong SA, et al. Safety and longterm efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn's disease. J Am Coll Surg. 2001;192:330-337.
15. Post S, Betzler M, von Ditfurth B, Schürmann G, Küppers P, Herfarth C. Risks of intestinal anastomoses in Crohn's disease. Ann Surg. 1991;213:37-42.
16. Yamamoto T, Keighley MR. Factors affecting the incidence of postoperative septic complications and recurrence after strictureplasty for jejunoileal Crohn's disease. Am J Surg. 1999;178:240-245.
17. Myrelid P, Olaison G, Sjödahl R, Nyström PO, Almer S, Andersson P. Thiopurine therapy is associated with postoperative intra-abdominal septic complications in abdominal surgery for Crohn's disease. Dis Colon Rectum. 2009;52:1387-1394.
18. Colombel JF, Loftus EV Jr, Tremaine WJ, et al. Early postoperative complications are not increased in patients with Crohn's disease treated perioperatively with infliximab or immunosuppressive therapy. Am J Gastroenterol. 2004;99:878-883.
19. Pennington L, Hamilton SR, Bayless TM, Cameron JL. Surgical management of Crohn's disease: Influence of disease at margin of resection. Ann Surg. 1980;192:311-318.
20. Simi M, Leardi S, Minervini S, Pietroletti R, Schietroma M, Speranza V. Early complications after surgery for Crohn's disease. Neth J Surg. 1990;42:105-109.
21. Hamilton SR, Reese J, Pennington L, Boitnott JK, Bayless TM, Cameron JL. The role of resection margin frozen section in the surgical management of Crohn's disease. Surg Gynecol Obstet. 1985;160:57-62.
22. Heuman R, Boeryd B, Bolin T, Sjödahl R. The influence of disease at the margin of resection on the outcome of Crohn's disease. Br J Surg. 1983;70:519-521.