Mild elevation of urinary biomarkers in prerenal acute kidney injury

Kidney International

Volumn 82, Issue 10, 2012, Pages 1114-1120

  Doi, Kent ^a   Katagiri, Daisuke ^a   Negishi, Kousuke ^a   Hasegawa, Sho ^a   Hamasaki, Yoshifumi ^a   Fujita, Toshiro ^a   Matsubara, Takehiro ^a   Ishii, Takeshi ^a   Yahagi, Naoki ^a   Sugaya, Takeshi ^b   Noiri, Eisei ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b Strategic and Regulatory Affairs Consulting Department   (Japan)

^c JAPAN INTERNATIONAL COOPERATION AGENCY   (Japan)

Author keywords

acute kidney injury; acute renal failure; L FABP; NGAL; volume depletion

Indexed keywords

ALBUMIN; BIOLOGICAL MARKER; CISPLATIN; FATTY ACID BINDING PROTEIN; INTERLEUKIN 18; N ACETYL BETA GLUCOSAMINIDASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PIMONIDAZOLE;

ACUTE KIDNEY FAILURE; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; HISTOPATHOLOGY; HUMAN; HYPOXIA; INTENSIVE CARE UNIT; KIDNEY ISCHEMIA; KIDNEY TUBULE DAMAGE; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REPERFUSION INJURY; SODIUM EXCRETION; URINARY EXCRETION;

ACETYLGLUCOSAMINIDASE; ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; AGED; ALBUMINURIA; ANIMALS; BIOLOGICAL MARKERS; CISPLATIN; DISEASE MODELS, ANIMAL; FATTY ACID-BINDING PROTEINS; FEMALE; HUMANS; INTENSIVE CARE UNITS; INTERLEUKIN-18; LIPOCALINS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, TRANSGENIC; MIDDLE AGED; ONCOGENE PROTEINS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS; REPERFUSION INJURY; UP-REGULATION;

EID: 84868537964     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.266     Document Type: Article

References (33)

1. Molitoris BA. Transitioning to therapy in ischemic acute renal failure. J Am Soc Nephrol 2003; 14: 265-267. (Pubitemid 36026318)
2. Murray PT, Devarajan P, Levey AS et al. A framework and key research questions in AKI diagnosis and staging in different environments. Clin J Am Soc Nephrol 2008; 3: 864-868.
3. Coca SG, Yalavarthy R, Concato J et al. Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. Kidney Int 2008; 73: 1008-1016. (Pubitemid 351543898)
4. Endre ZH, Pickering JW, Walker RJ. Clearance and beyond: the complementary roles of GFR measurement and injury biomarkers in acute kidney injury (AKI). Am J Physiol Renal Physiol 2011; 301: F697-F707.
5. Siew ED, Ware LB, Ikizler TA. Biological markers of acute kidney injury. J Am Soc Nephrol 2011; 22: 810-820.
6. Nguyen MT, Devarajan P. Biomarkers for the early detection of acute kidney injury. Pediatr Nephrol 2008; 23: 2151-2157.
7. Parikh CR, Devarajan P. New biomarkers of acute kidney injury. Crit Care Med 2008; 36: S159-S165. (Pubitemid 351483046)
8. Waikar SS, Bonventre JV. Biomarkers for the diagnosis of acute kidney injury. Curr Opin Nephrol Hypertens 2007; 16: 557-564. (Pubitemid 350293749)
9. Noiri E, Doi K, Negishi K et al. Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury. Am J Physiol Renal Physiol 2009; 296: F669-F679.
10. Perazella MA, Coca SG, Hall IE et al. Urine microscopy is associated with severity and worsening of acute kidney injury in hospitalized patients. Clin J Am Soc Nephrol 2011; 5: 402-408.
11. Himmelfarb J, Joannidis M, Molitoris B et al. Evaluation and initial management of acute kidney injury. Clin J Am Soc Nephrol 2008; 3: 962-967.
12. Prowle JR, Echeverri JE, Ligabo EV et al. Fluid balance and acute kidney injury. Nat Rev Nephrol 2010; 6: 107-115.
13. Bouchard J, Soroko SB, Chertow GM et al. Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int 2009; 76: 422-427.
14. Nejat M, Pickering JW, Devarajan P et al. Some biomarkers of acute kidney injury are increased in pre-renal injury. Kidney Int 2012; 81: 1254-1262.
15. Doi K, Negishi K, Ishizu T et al. Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit. Crit Care Med 2011; 39: 2464-2469.
16. Negishi K, Noiri E, Maeda R et al. Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney injury. Kidney Int 2008; 73: 1374-1384. (Pubitemid 351770480)
17. Negishi K, Noiri E, Doi K et al. Monitoring of urinary L-type fatty acidbinding protein predicts histological severity of acute kidney injury. Am J Pathol 2009; 174: 1154-1159.
18. Arteel GE, Thurman RG, Raleigh JA. Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. Eur J Biochem 1998; 253: 743-750. (Pubitemid 28223543)
19. Ralib AM, Pickering JW, Shaw GM et al. Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J Am Soc Nephrol 2012; 23: 322-333.
20. Nickolas TL, O'Rourke MJ, Yang J et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 2008; 148: 810-819. (Pubitemid 351786928)
21. Singer E, Elger A, Elitok S et al. Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney Int 2011; 80: 405-414.
22. Paragas N, Qiu A, Zhang Q et al. The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat Med 2011; 17: 216-222.
23. Gobe G, Zhang XJ, Willgoss DA et al. Relationship between expression of Bcl-2 genes and growth factors in ischemic acute renal failure in the rat. J Am Soc Nephrol 2000; 11: 454-467. (Pubitemid 30115075)
24. Han WK, Waikar SS, Johnson A et al. Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int 2008; 73: 863-869. (Pubitemid 351398278)
25. Ware LB, Johnson AC, Zager RA. Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury. Am J Physiol Renal Physiol 2011; 300: F628-F638.
26. Parikh CR, Jani A, Melnikov VY et al. Urinary interleukin-18 is a marker of human acute tubular necrosis. Am J Kidney Dis 2004; 43: 405-414. (Pubitemid 38298199)
27. Han WK, Wagener G, Zhu Y et al. Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol 2009; 4: 873-882.
28. Katagiri D, Doi K, Honda K et al. Combination of two urinary biomarkers predicts acute kidney injury after adult cardiac surgery. Ann Thorac Surg 2012; 93: 577-583.
29. Endre ZH, Pickering JW, Walker RJ et al. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int 2011; 79: 1119-1130.
30. Yamamoto T, Noiri E, Ono Y et al. Renal L-type fatty acid-binding protein in acute ischemic injury. J Am Soc Nephrol 2007; 18: 2894-2902. (Pubitemid 350058396)
31. Doi K, Noiri E, Maeda-Mamiya R et al. Urinary L-type fatty acid-binding protein as a new biomarker of sepsis complicated with acute kidney injury. Crit Care Med 2010; 38: 2037-2042.
32. Tanaka T, Doi K, Maeda-Mamiya R et al. Urinary L-type fatty acid-binding protein can reflect renal tubulointerstitial injury. Am J Pathol 2009; 174: 1203-1211.
33. Yasuda H, Yuen PS, Hu X et al. Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int 2006; 69: 1535-1542.