Metabolic profiling: Are we en route to better diagnostic tests for cancer?

Future Oncology

Volumn 8, Issue 10, 2012, Pages 1207-1210

  Gu, Haiwei ^a   Gowda, G A Nagana ^a   Raftery, Daniel ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

biomarker; cancer; diagnostic; metabolic profiling; metabolomics

Indexed keywords

ALPHA FETOPROTEIN; CARCINOEMBRYONIC ANTIGEN; PROSTATE SPECIFIC ANTIGEN; TUMOR MARKER;

ADVANCED CANCER; CANCER DIAGNOSIS; CANCER PATIENT; COMPUTER ASSISTED TOMOGRAPHY; EARLY DIAGNOSIS; ECHOGRAPHY; HUMAN; MASS SPECTROMETRY; METABOLOMICS; NEOPLASM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW;

DIAGNOSTIC TESTS, ROUTINE; HUMANS; METABOLOME; METABOLOMICS; NEOPLASMS;

EID: 84868537255     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.12.113     Document Type: Review

References (20)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012 CA Cancer J. Clin. 62(1), 10-29 (2012
2. Sell S. Detection of cancer by tumor-markers in the blood - a view to the future. Crit. Rev. Oncog. 4(4), 419-433 (1993
3. Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11), 1181-1189 (1999
4. Gowda GAN, Zhang SC, Gu HW, Asiago V, Shanaiah N, Raftery D. Metabolomics-based methods for early disease diagnostics. Expert Rev. Mol. Diagn. 8(5), 617-633 (2008
5. Fiehn O. Metabolomics - the link between genotypes and phenotypes. Plant. Mol. Biol. 48(1-2), 155-171 (2002 (Pubitemid 34128498)
6. Raftery D, Gowda GAN. An approaching new wave of multicomponent biomarker diagnostics? J. Urol. 179(6), 2089-2090 (2008
7. Warburg O. On the origin of cancer cells. Science 123(3191), 309-314 (1956
8. DeBerardinis RJ, Mancuso A, Daikhin E et al. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl Acad. Sci. USA 104(49), 19345-19350 (2007
9. Johnson RA, Wichern DW
10. Kim YS, Maruvada P. Frontiers in metabolomics for cancer research: Proceedings of a National Cancer Institute workshop. Metabolomics 4(2), 105-113 (2008
11. Wishart DS, Tzur D, Knox C et al. HMDB: The human metabolome database. Nucleic Acids Res. 35, D521-D526 (2007 (Pubitemid 46056263)
12. Ye T, Mo HP, Shanaiah N, Gowda GAN, Zhang SC, Raftery D. Chemoselective (15)N tag for sensitive and high-resolution nuclear magnetic resonance profiling of the carboxyl-containing metabolome. Anal. Chem. 81(12), 4882-4888 (2009
13. Gu HW, Pan ZZ, Xi BW, Asiago V, Musselman B, Raftery D. Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics: Application to the detection of breast cancer. Anal. Chim. Acta 686(1-2), 57-63 (2011
14. Issaq HJ, Fox SD, Chan KC, Veenstra TD. Global proteomics and metabolomics in cancer biomarker discovery. J. Sep. Sci. 34(24), 3484-3492 (2011
15. Spratlin JL, Serkova NJ, Eckhardt SG. Clinical applications of metabolomics in oncology: A review. Clin. Cancer Res. 15(2), 431-440 (2009
16. Giskeodegard GF, Grinde MT, Sitter B et al. Multivariate modeling and prediction of breast cancer prognostic factors using MR metabolomics. J. Proteome Res. 9(2), 972-979 (2010
17. Asiago VM, Alvarado LZ, Shanaiah N et al. Early detection of recurrent breast cancer using metabolite profiling. Cancer Res. 70(21), 8309-8318 (2010
18. DeFeo EM, Wu CL, McDougal WS, Cheng LL. A decade in prostate cancer: from NMR to metabolomics. Nat. Rev. Urol. 8(6), 301-311 (2011
19. Kline EE, Treat EG, Averna TA, Davis MS, Smith AY, Sillerud LO. Citrate concentrations in human seminal fluid and expressed prostatic fluid determined via H-1 nuclear magnetic resonance spectroscopy outperform prostate specific antigen in prostate cancer detection. J. Urol. 176(5), 2274-2279 (2006 (Pubitemid 44633142)
20. Sreekumar A, Poisson LM, Rajendiran TM et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457(7231), 910-914 (2009