Anthrax toxin protective antigen integrates poly-γ-D-glutamate and pH signals to sense the optimal environment for channel formation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 45, 2012, Pages 18378-18383

  Kintzer, Alexander F ^a   Tang, Iok I ^a   Schawel, Adam K ^a   Brown, Michael J ^a   Krantz, Bryan A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

pH sensor; Planar bilayer electrophysiology; Translocation

Indexed keywords

ANTHRAX TOXIN; ANTIGEN; OLIGOMER; POLY(GAMMA DEXTRO GLUTAMIC ACID); PROTECTIVE ANTIGEN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; BINDING SITE; CHANNEL GATING; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYTOTOXICITY; ENDOCYTOSIS; ENZYME BINDING; HOST CELL; LETHAL GENE; MAMMAL CELL; OLIGOMERIZATION; PH; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL CAPSULES; BACTERIAL TOXINS; BINDING SITES; CELL DEATH; CELL LINE; HYDROGEN-ION CONCENTRATION; ION CHANNELS; MICE; MODELS, MOLECULAR; POLYGLUTAMIC ACID; PROTEIN BINDING; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

BACILLUS ANTHRACIS; MAMMALIA;

EID: 84868523318     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208280109     Document Type: Article

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