Assam bora rice starch based biocompatible mucoadhesive microsphere for targeted delivery of 5-fluorouracil in colorectal cancer

Molecular Pharmaceutics

Volumn 9, Issue 11, 2012, Pages 2986-2994

  Ahmad, Mohammad Zaki ^a   Akhter, Sohail ^b   Anwar, Mohammed ^b   Ahmad, Farhan Jalees ^b  

^a Dreamz College of Pharmacy   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

5 fluorouracil; Assam Bora rice starch; colon specific; drug absorption and organ distribution; mucoadhesion

Indexed keywords

ALBUMIN; ASSAM BORA RICE STARCH; CREATININE; FLUOROURACIL; LIVER ENZYME; MICROSPHERE; MUCOADHESIVE MICROSPHERE; POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; COLORECTAL CANCER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; EVAPORATION; IN VIVO STUDY; LEUKOPENIA; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SMALL INTESTINE; STOMACH; THROMBOCYTOPENIA; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADHESIVENESS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; COATED MATERIALS, BIOCOMPATIBLE; COLORECTAL NEOPLASMS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FLUOROURACIL; GASTROINTESTINAL TRACT; GOATS; MALE; MICROSPHERES; ORYZA SATIVA; PARTICLE SIZE; RATS; STARCH; TISSUE DISTRIBUTION;

EID: 84868521946     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300289y     Document Type: Article

References (42)

1. Paharia, A.; Yadav, A. K.; Rai, G.; Jain, S. K.; Pancholi, S. S.; Agrawal, G. P. Eudragit-coated pectin microspheres of 5-fluorouracil for colon targeting AAPS PharmSciTech 2007, 8 (1) E87-E93
2. National cancer institute, US national institute of health. www.cancer.gov, accessed on 22nd February 2011.
3. Labianca, R. F.; Beretta, G.; D, Pessi, M. A. Disease management considerations: disease management considerations Drugs 2001, 61, 1751-1764
4. http://www.cancer.gov/aboutnci/ncicancerbulletin/archive/2009/011309, accessed on 22nd February 2011.
5. Wilkinson, D. S.; Crumley, J. The mechanism of 5-fluorouridine toxicity in Novikoff hepatoma cells Cancer Res. 1976, 36, 4032-4038
6. Glazer, R. I.; Peale, A. L. The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro Mol. Pharmacol. 1979, 16, 270-277
7. Ardalan, B.; Cooney, D. A.; Jayaram, H. N.; Carrico, C. K.; Glazar, R. I.; Macdonald, J.; Schein, P. S. Mechanisms of sensitivity and resistance of murine tumours to 5-fluorouracil Cancer Res. 1980, 40, 1431-1437
8. Kufe, D. W.; Major., P. P.; Egan, E. M.; Loh, E. 5-Fluoro-2′- deoxyuridine incorporation in L1210 DNA J. Biol. Chem. 1981, 256, 8885-8888
9. Major, P. P.; Egan, E.; Derrick, D.; Kufe, D. W. 5-fluorouracil incorporation in DNA of human breast carcinoma cells Cancer Res. 1982, 42, 3005-3009
10. Hahn, R. G.; Moertel, C. G.; Schutt, A. J. A double blind comparison of intensive course 5-fluorouracil by oral versus intravenous route in the treatment of colorectal carcinoma Cancer 1975, 35, 1031-1035
11. Djordjeuic, B.; Lange, C. S.; Allison, R. R.; Rotman, M. Response of primary colon cancer cells in hybrid spheroids to fluorouracil Cancer Invest. 1993, 11, 291-293
12. Herrmann, R. Systemic treatment of colorectal cancer Eur. J. Cancer 1993, 30A, 404-409
13. Rahman, Z.; Kohli, K.; Zhang, S. Q.; Khar, R. K.; Ali, M.; Charoo, N. A.; Tauseef, M.; Shamsher, A. A.; Mohammed, N. N.; Repka, M. A. In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil J. Pharm. Pharmacol. 2008, 60 (5) 615-623
14. Krishnaiah, Y. S.; Satyanarayana, V.; Dinesh Kumar, B.; Karthikeyan, R. S. In vitro drug release studies on guar gum-based colon targeted oral drug delivery systems of 5-fluorouracil Eur. J. Pharm. Sci. 2002, 16 (3) 185-192
15. Jain, A.; Gupta, Y.; Jain, S. K. Potential of calcium pectinate beads for target specific drug release to colon J. Drug Targeting 2007, 15 (4) 285-294
16. Cortesi, E.; Ashelter, A. M.; Goacchini, N.; Pellegrini, A.; Frati., L.; Ficorella, C.; Mazzei, N.; Marchetti., P. Efficacy and toxicity of 5-fluorouracil and folates in advanced colon cancer J. Chemother. 1990, 2, 47-50
17. Watts, P. J.; Barrow, L.; Steed, K. P.; Wilson, C. G.; Spiller, R. C.; Mellia, C. D.; Davies, M. C. The transit rate of different sized model dosage forms through the human colon and the effects of a lactulose-induced catharsis Int. J. Pharm. 1992, 87, 215-221
18. Yang, L.; Chu, J. S.; Fix, J. A. Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation Int. J. Pharm. 2002, 235, 1-15
19. Krishnaiah, Y. S.; Bhaskar Reddy, P. R.; Satyanarayana, V; Karthikeyan, R. S. Studies on the development of oral colon targeted drug delivery systems for metronidazole in the treatment of amoebiasis Int. J. Pharm. 2002, 236 (1-2) 43-55
20. Sinha, V. R.; Kumaria, R.l. Polysaccharides in colon-specific drug delivery Int. J. Pharm. 2001, 224 (1-2) 19-38
21. Scheline, R. R. Metabolism of foreign compounds by gastrointestinal microorganisms Pharmacol Rev. 1973, 25, 451-523
22. Park, K.; Shalaby, S. W. W.; Park, H. Biodegradation. In Biodegradable hydrogels for drug delivery; Technomic publishing company: USA, 1993; pp 13-34.
23. Tugcu-Demiroz, F.; Acarturk, F.; Takka, S. Investigation of colon-specific dosage forms of ondansetron prepared with natural polymers Pharmazie 2006, 61, 916-919
24. Wu, B.; Deng, D.; Lu, Y.; Wu, W. Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: II. Influencing variables, stability and pharmacokinetics in dogs Eur. J. Pharm. Biopharm. 2008, 69 (1) 294-302
25. Sharma, S. D.; Vellanki, J. M. R.; Hakim, K. I.; Singh, R. K. Primitive and current cultivars of rice in Assam a rich source of valuable genes Curr. Sci. 1971, 40, 126-128
26. Ahmad, M. Z.; Bhattacharya, A. Isolation and physicochemical characterization of Assam Bora rice starch for use as a plasma volume expander Curr. Drug Delivery 2010, 7 (2) 162-167
27. Ahmad, M. Z.; Akhter, S.; Rahman, M.; Ahmad, I.; Anwar, M.; Jain, G. K.; Ahmad, F. J.; Khar, R. K. Development of polysaccharide based colon targeted drug delivery system: design and evaluation of Assam Bora rice starch based matrix tablet Curr. Drug Delivery 2011, 8 (5) 575-581
28. Ahmad, M. Z.; Akhter, S.; Ahmad, I.; Singh, A.; Anwar, M; Shamim, M.; Ahmad, F. J. In vitro and in vivo evaluation of Assam Bora rice starch based bioadhesive microsphere as drug carrier for colon targeting Expert Opin. Drug Delivery 2012, 9 (2) 141-149
29. Bhattacharya, A.; Akhter, S.; Shahnawaz, S.; Siddiqui, A. W.; Ahamad, M. Z. Evaluation of Assam Bora rice starch as plasma volume expander by polymer analysis Curr. Drug Delivery 2010, 7 (5) 436-441
30. Ahmad, M. Z.; Akhter, S.; Anwar, M.; Rahman, M.; Siddiqui, M. A.; Ahmad, F. J. Compactibility and compressibility studies of Assam Bora rice starch Powder Technol. 2012, 224, 281-286
31. Sandra, K.; Gareth, D. R.; John, T.; Smart, J. D. Mucoadhesive triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics Eur. J. Pharm. Biopharm. 2005, 59 (1) 207-216
32. Thirawong, N.; Nunthanid, J.; Puttipipatkhachorn, S.; Sriamornsak, P. Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer Eur. J. Pharm. Biopharm. 2007, 67 (1) 132-140
33. Jain, S.; Chourasia, M.; Jain, A.; Jain, R. Development and Characterization of mucoadhesive microspheres bearing salbutamol for nasal Delivery Drug Delivery 2004, 1, 113-122
34. Begemeyer, H. U.; Scheibe, P.; Wahlefeld, A. W. Optimization of methods for aspartate aminotransferase and alanine aminotransferase Clin. Chem. 1978, 24, 58-73
35. Orhanovic, S.; Pavela-Vrancic, M. Alkaline phosphatase activity in sea waters, influence of reactive conditions on the kinetic parameters of ALP Croat. Chem. Acta 2000, 73, 819-830
36. Michael, L.; Greggory, C. Effect of calcium and magnesium on urinary oxalate excretion after oxalate loads J. Urol. 2000, 163, 1565-1569
37. Guijarro, C.; Massay, Z. A.; Wiederkehr, M. R.; Ma, J. Z.; Kasiske, B. L. Serum albumin and mortality after renal transplantation Am. J. Kidney Dis. 1996, 27, 117-123
38. Lehr, C. M.; Bouwstra, J. A.; Tukker, J. J.; Junginger, H. E. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat - A comparative study with copolymers and blends based on poly(acrylic acid) J. Controlled Release 1990, 13, 51-62
39. Mortazavi, S. A.; Smart, J. D. An investigation into the role of water movement and mucus gel dehydration in mucoadhesion J. Controlled Release 1993, 25, 197-203
40. Duchene, D.; Ponchel, G. Principle and investigation of bioadhesion mechanism of solid dosage forms Biomaterials 1992, 13, 709-714
41. Laurence, L.; Brunton, K.; Parker, L. Chemotherapy of neoplastic disease. In Goodman & Gilmans: Manual of pharmacology and Therapeutics; McGraw Hill Medical: New York, 2006; pp 853-908.
42. Wei, H.; Qing, D.; De-Ying, C.; Bai, X.; Li-Fang, F. Study on colon-specific pectin/ethylcellulose film-coated 5-fluorouracil pellets in rats Int. J. Pharm. 2008, 348, 35-45