In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil

Journal of Pharmacy and Pharmacology

Volumn 60, Issue 5, 2008, Pages 615-623

  Rahman, Ziyaur ^a,b   Kohli, Kanchan ^a   Zhang, Shuang Qing ^b   Khar, Roop K ^a   Ali, Mushir ^a   Charoo, Naseem A ^a   Tauseef, Mohammad ^c   Shamsher, Areeg A A ^a   Mohammed, Noorullah N ^b   Repka, Michael A ^b  

^a HAMDARD UNIVERSITY   (India)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c UNIVERSITY OF DELHI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYLHYDRAZINE; ALANINE AMINOTRANSFERASE; ALBUMIN; ALGINIC ACID; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATININE; EUDRAGIT; FLUOROURACIL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; COLON; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG DISTRIBUTION; IC 50; LEUKOPENIA; MALE; MICROENCAPSULATION; NONHUMAN; RAT; THROMBOCYTOPENIA;

1,2-DIMETHYLHYDRAZINE; ALGINATES; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CECUM; COLON; COLONIC NEOPLASMS; FLUOROURACIL; GLUCURONIC ACID; HEXURONIC ACIDS; INTESTINE, SMALL; MALE; MICROSPHERES; POLYMETHACRYLIC ACIDS; RATS; RATS, WISTAR; STOMACH; TUMOR BURDEN;

EID: 42549125576     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.60.5.0007     Document Type: Article

References (38)

1. Ardalan, B., Cooney, D. A., Jayaram, H. N., Carrico, C. K., Glazar, R. I., Macdonald, J., Schein P. S. (1980) Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil. Cancer Res. 40: 1431-1437
2. Begemeyer, H. U., Scheibe, P., Wahlefeld, A. W. (1978) Optimization of methods for aspartate aminotransferase and alanine aminotransferase. Clin. Chem. 24: 58-73
3. Chabner, B. A., Allegra, C. J., Curt, G. A., Calabresi, P. (1996) Anti-neoplastic agents. In: Hardman, J. G., Limbird, L. E., Berry, P. M., Raymond, W. R. (eds), Goodman and Gilman's the pharmacological basis of therapeutics, 9th edn. Mcgraw-Hill, New Delhi, pp. 1233-1287
4. Copur, S., Aiba, K, Drake, J. C., Allegra, C. J., Chu, E. (1995) Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. Biochem. Pharmacol. 49: 1419-1426
5. Cortesi, E., Ashelter, A. M., Goacchini, N., Pellegrini, A., Frati, L., Ficorella, C., Mazzei, N., Marchetti, P. (1990) Efficacy and toxicity of 5-fluorouracil and folates in advanced colon cancer. J. Chemother. 2: 47-50
6. Djordjeuic, B., Lange, C. S., Allison, R. R., Rotman, M. (1993) Response of primary colon cancer cells in hybrid spheroids to fluorouracil. Cancer Invest. 11: 291-293
7. Fiala, E. S. (1977) Investigation into metabolism and mode of action of the colon carcinogen 1,2-dimethylhydrazine and azoxymethane. Cancer 40: 2436-2445
8. Fiala, E. S., Sohn, O. S., Hamilton, S. R. (1987) Effects of chronic dietary ethanol on the in vivo and in vitro metabolism of methylazoxymethanol and on methylazoxymethanol induced DNA methylation in the rat colon and liver. Cancer Res. 47: 5939-5943
9. Fischel, J. L., Etienne, M. C., Spector, T., Formento, P., Renee, N., Milano, G. (1995) Dihydropyrimidine dehydrogenase: a tumoral target for fluorouracil modulation. Clin. Cancer Res. 1: 991-996
10. Glazer, R. I., Peale, A. L. (1979) The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro. Mol. Pharmacol. 16: 270-277
11. Guijarro, C., Massay, Z. A., Wiederkehr, M. R., Ma, J. Z., Kasiske, B. L. (1996) Serum albumin and mortality after renal transplantation. Am. J. Kidney Dis. 27: 117-123
12. Hahn, R. G., Moertel, C. G., Schutt, A. J. (1975) A double blind comparison of intensive course 5-fluorouracil by oral versus intravenous route in the treatment of colorectal carcinoma. Cancer 35: 1031-1035
13. Herrmann, R. (1993) Systemic treatment of colorectal cancer. Eur. J. Cancer 29A: 583-586
14. Ishikawa, T., Utoh, M., Sawada, N., Nishida, M., Fukase, Y., Sekigochi, F., Ishitsuka, H. (1998) Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts. Biochem. Pharmacol. 55: 1091-1097
15. Jain, A., Gupta, Y., Jain, S. K. (2007) Potential of calcium pectinate beads for target specific drug release to colon. J. Drug Target. 15: 285-294
16. Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., Thun, M. J. (2007) Cancer statistics, 2007. CA Cancer J. Clin. 57: 43-66
17. Jung, M., Berger, G., Pohlen, U., Pauser, S., Reszka, R., Buhr, H. J. (1997) Simultaneous determination of 5-fluorouracil and its metabolites in serum and tissue by high performance liquid chromatography. J. Chromatogr. B 702: 193-202
18. Kufe, D. W., Major, P. P., Egan, E. M., Loh. E. (1981) 5-fluoro-2′-deoxyuridine incorporation in L1210 DNA. J. Biol. Chem. 256: 8885-8888
19. Labianca, R. F., Beretta, G. D., Pessi, M. A. (2001) Disease management considerations: disease management considerations. Drugs 61: 1751-1764
20. LaMont, J. T., O'Gorman, T. A. (1978) Experimental colon cancer. Gastroenterology 75: 1157-1169
21. Li, W., Li, C-B. (2003) lack of inhibitory effects of lactic acid bacteria on 1,2-dimethylhydrazine-induced colon tumors in rats. World J. Gastroenterol. 9: 2469-2473
22. Major, P. P., Egan, E., Derrick, D., Kufe, D. W. (1982) 5-fluorouracil incorporation in DNA of human breast carcinoma cells. Cancer Res. 42: 3005-3009
23. Meropol, N. J. (1998) Clinical oncology update, oral fluoropyrimidines in the treatment of colorectal cancer. Eur. J. Cancer 34: 1509-1513
24. Michael, L., Greggory, C. (2000) Effect of calcium and magnesium on urinary oxalate excretion after oxalate loads. J. Urol. 163: 1565-1569
25. Mundargi, R. C., Patil, S. A., Agnihotri, S. A., Aminabhavi, T. M. (2007) Development of polysaccharide-based colon targeted drug delivery systems for the treatment of amoebiasis. Drug Dev. Ind. Pharm. 3: 255-264
26. Nykänen, P., Sten, T., Jürjenson, H., Veski, P., Marvola, M. (2004) Citric acid as a pH-regulating additive in granules and the tablet matrix in enteric-coated formulations for colon-specific drug delivery. Pharmazie 59: 268-273
27. Orhanovic, S., Pavela-Vrancic, M. (2000) Alkaline phosphatase activity in sea waters, influence of reactive conditions on the kinetic parameters of ALP. Croatica Chem. Acta 73: 819-830
28. Preezel, N. C., Webling, D. D. A. (1971) The length and mucosal surface area of the small and large gut in young rat. J. Anat. 108: 295-296
29. Rahman, Z., Kohli, K., Khar, R. K., Ali, M., Charoo, N. A., Shamsher, A. A. A. (2006) Characterization of 5-fluorouracil microspheres for colon-specific delivery. AAPS Pharm Sci Tech 7(2), article 47, E1-E9
30. Sandle, G. I. (1998) Salt and water absorption in the human colon: a modern appraisal. Gut 43: 294-299
31. Tuǧcu-Demiröz, F., Acartürk, F., Takka, S. (2006) Investigation of colon-specific dosage forms of ondansetron prepared with natural polymers. Pharmazie 61: 916-919
32. Watts, P. J., Barrow L., Steed, K. P., Wilson, C. G, Spiller, R. C., Mellia C. D., Davies, M. C. (1992) The transit rate of different sized model dosage forms through the human colon and he effects of a lactulose-induced catharsis. Int. J. Pharm. 87: 215-221
33. Wei, H., Qing, D., De-Ying, C., Bai, X., Li-Fang, F. (2008) Study on colon-specific pectin/ethylcellulose film-coated 5-fluorouracil pellets in rats, Int. J. Pharm. 348: 35-45.
34. Wilkinson, D. S., Crumley, J. (1976) The mechanism of 5-fluorouridine toxicity in Novikoff hepatoma cells. Cancer Res. 36: 4032-4038
35. Wu, B., Deng, D., Lu, Y., Wu, W. (2007) Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: II. Influencing variables, stability and pharmacokinetics in dogs. Eur. J. Pharm. Biopharm. Oct 5 [Epub ahead of print].
36. Yang, L., Chu, J. S., Fix, J. A. (2002) Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation. Int. J. Pharm. 235: 1-15
37. Yoon, S. S., Eto, H., Lin, C. M., Nakamura, H., Pawlik, T. M., Song, S. U., Tanabe, K. K. (1999) Mouse endostatin inhibits the formation of lung and liver metastases. Cancer Res. 59: 6251-6256
38. Zambito, Y., Baggiani, A., Carelli, V., Serafini, M. F., Di., G. (2005) Matrices for site-specific controlled-delivery of 5-fluorouracil to descending colon. J. Control. Release 102: 669-677