A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen

BMC Systems Biology

Volumn 6, Issue , 2012, Pages

  Lebedeva, Galina ^a   Yamaguchi, Azusa ^a   Langdon, Simon P ^a   Macleod, Kenneth ^a   Harrison, David J ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Cancer; Estrogen receptor; Global sensitivity analysis; Mathematical model; SERM; Tamoxifen

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TRANSCRIPTOME;

ARTICLE; BIOLOGICAL MODEL; CELL STRAIN HEK293; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; NONLINEAR SYSTEM; REPRODUCIBILITY;

ESTROGEN RECEPTOR ALPHA; ESTROGENS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; REPRODUCIBILITY OF RESULTS; RESPONSE ELEMENTS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

MLCS; MLOWN;

EID: 84868513344     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-6-138     Document Type: Article

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