Papillary mucinous metaplasia of the endometrium as a possible precursor of endometrial mucinous adenocarcinoma

Modern Pathology

Volumn 25, Issue 11, 2012, Pages 1496-1507

  Yoo, Su Hyun ^a   Park, Bong Hee ^a   Choi, Jene ^a   Yoo, Jin ^a   Lee, Shin Wha ^a   Kim, Yong Man ^a   Kim, Kyu Rae ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

endometrium; mucinous; mucinous metaplasia; P16INK4A; papillary metaplasia; PAX2; senescence

Indexed keywords

BETA CATENIN; ESTROGEN RECEPTOR; K RAS PROTEIN; MKI67 PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE RECEPTOR; PROTEIN P16; PROTEIN P53; TRANSCRIPTION FACTOR PAX2; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTADENOCARCINOMA; DISEASE ASSOCIATION; ENDOMETRIAL MUCINOUS METAPLASIA; ENDOMETRIUM; ENDOMETRIUM CARCINOMA; FEMALE; GENE EXPRESSION PROFILING; GENE MUTATION; GENE OVEREXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METAPLASIA; PAPILLARY CARCINOMA; PATHOGENESIS; POSTMENOPAUSE; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA, MUCINOUS; BETA CATENIN; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; METAPLASIA; MIDDLE AGED; MUTATION; PAX2 TRANSCRIPTION FACTOR; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS; PTEN PHOSPHOHYDROLASE; RAS PROTEINS; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84868510074     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.113     Document Type: Article

References (28)

1. Fujiwara M, Longacre TA. Low-grade mucinous adenocarcinoma of the uterine corpus: a rare and deceptively bland form of endometrial carcinoma. Am J Surg Pathol 2011;35:537-544.
2. Young RH, Scully RE. Uterine carcinomas simulating microglandular hyperplasia. A report of six cases. Am J Surg Pathol 1992;16:1092-1097.
3. Qiu W, Mittal K. Comparison of morphologic and immunohistochemical features of cervical microglandular hyperplasia with low-grade mucinous adenocarcinoma of the endometrium. Int J Gynecol Pathol 2003;22:261-265. (Pubitemid 36750408)
4. Zaloudek C, Hayashi GM, Ryan IP, et al. Microglandular adenocarcinoma of the endometrium: a form of mucinous adenocarcinoma that may be confused with microglandular hyperplasia of the cervix. Int J Gynecol Pathol 1997;16:52-59. (Pubitemid 27199586)
5. Giordano G, D'Adda T, Gnetti L, et al. Endometrial mucinous microglandular adenocarcinoma: morphologic, immunohistochemical features, and emphasis in the human papillomavirus status. Int J Gynecol Pathol 2006;25:77-82. (Pubitemid 44638340)
6. Melhem MF, Tobon H. Mucinous adenocarcinoma of the endometrium: a clinico-pathological review of 18 cases. Int J Gynecol Pathol 1987;6:347-355.
7. Young R, Scully R. Uterine carcinomas simulating microglandular hyperplasia. A report of six cases. Am J Surg Pathol 1992;16:1092-1097.
8. Nucci MR, Prasad CJ, Crum CP, et al. Mucinous endometrial epithelial proliferations: a morphologic spectrum of changes with diverse clinical significance. Mod Pathol 1999;12:1137-1142. (Pubitemid 30033547)
9. Mount SL. Mucinous metaplasias of the endometrium: biologically meaningful subsets for the practicing surgical pathologist. Adv Anat Pathol 2000;7:197-200.
10. Nicolae A, Preda O, Nogales FF. Endometrial metaplasias and reactive changes: a spectrum of altered differentiation. J Clin Pathol 2011;64:97-106.
11. Lehman MB, Hart WR. Simple and complex hyperplastic papillary proliferations of the endometrium: a clinicopathologic study of nine cases of apparently localized papillary lesions with fibrovascular stromal cores and epithelial metaplasia. Am J Surg Pathol 2001;25:1347-1354. (Pubitemid 33022049)
12. Fukunaga M. Mucinous endometrial adenocarcinoma simulating microglandular hyperplasia of the cervix. Pathol Int 2000;50:541-545. (Pubitemid 30609862)
13. Hendrickson MR, Kempson RL. Endometrial epithelial metaplasias: proliferations frequently misdiagnosed as adenocarcinoma. Report of 89 cases and proposed classification. Am J Surg Pathol 1980;4: 525-542. (Pubitemid 11104410)
14. Vang R, Tavassoli FA. Proliferative mucinous lesions of the endometrium: analysis of existing criteria for diagnosing carcinoma in biopsies and curettings. Int J Surg Pathol 2003;11:261-270. (Pubitemid 37433285)
15. von Knebel Doeberitz M. New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections. Eur J Cancer 2002;38:2229-2242. (Pubitemid 35346464)
16. Gutierrez-Reyes G, del Carmen Garcia de Leon M, Varela-Fascinetto G, et al. Cellular senescence in livers from children with end stage liver disease. PLoS One 2010;5:e10231.
17. Dankort D, Filenova E, Collado M, et al. A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev 2007;21:379-384.
18. Bennecke M, Kriegl L, Bajbouj M, et al. Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis. Cancer Cell 2010;18:135-146.
19. Abe K, Suda K, Arakawa A, et al. Different patterns of p16INK4A and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia. Pancreas 2007;34:85-91. (Pubitemid 46045725)
20. Zhai QJ, Ozcan A, Hamilton C, et al. PAX-2 expression in non-neoplastic, primary neoplastic, and metastatic neoplastic tissue: a comprehensive immunohistochemical study. Appl Immunohistochem Mol Morphol 2010;18:323-332.
21. Dahl E, Koseki H, Balling R. Pax genes and organogenesis. Bioessays 1997;19:755-765. (Pubitemid 27383751)
22. Monte NM, Webster KA, Neuberg D, et al. Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer. Cancer Res 2010;70:6225-6232.
23. Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nat Rev Cancer 2003;3:459-465. (Pubitemid 37328850)
24. Bos JL. ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-4689. (Pubitemid 19213607)
25. Enomoto T, Weghorst CM, Inoue M, et al. K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary. Am J Pathol 1991;139:777-785.
26. Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006;24: 4783-4791. (Pubitemid 46630943)
27. Lax SF, Kendall B, Tashiro H, et al. The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer 2000;88:814-824. (Pubitemid 30091101)
28. Jarboe EA, Mutter GL. Endometrial intraepithelial neoplasia. Semin Diagn Pathol 2010;27:215-225.