Endometrial intraepithelial neoplasia

Seminars in Diagnostic Pathology

Volumn 27, Issue 4, 2010, Pages 215-225

  Jarboe, Elke A ^a   Mutter, George L ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Endometrial adenocarcinoma; Endometrial hyperplasia; Endometrial intraepithelial neoplasia; Premalignant

Indexed keywords

ESTROGEN; GESTAGEN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TRANSCRIPTION FACTOR PAX2;

ARTICLE; CANCER DIAGNOSIS; CANCER GROWTH; CANCER RISK; CARCINOGENESIS; CYTOLOGY; DIFFERENTIAL DIAGNOSIS; DRUG MEGADOSE; ENDOMETRIAL INTRAEPITHELIAL NEOPLASIA; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CARCINOMA; GENE ACTIVATION; GENE MUTATION; GENETIC DAMAGE; HUMAN; PATHOPHYSIOLOGY; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROUS ENDOMETRIAL INTRAEPITHELIAL CARCINOMA; TUMOR SUPPRESSOR GENE;

CARCINOMA IN SITU; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; PRECANCEROUS CONDITIONS;

EID: 78650128277     PISSN: 07402570     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semdp.2010.09.007     Document Type: Article

References (27)

1. Jemal A., Siegel R., Xu J. Cancer statistics. CA Cancer J Clin 2010, 60:277-300.
2. Kendall B.S., Ronnett B.M., Isacson C., et al. Reproducibility of the diagnosis of endometrial hyperplasia, atypical hyperplasia, and well-differentiated carcinoma. Am J Surg Pathol 1998, 22:1012-1019.
3. Bergeron C., Nogales F.F., Masseroli M., et al. A multicentric European study testing the reproducibility of the WHO classification of endometrial hyperplasia with a proposal of a simplified working classification for biopsy and curettage specimens. Am J Surg Pathol 1999, 23:1102-1108.
4. Zaino R.J. Endometrial hyperplasia: Is it time for a quantum leap to a new classification?. Int J Gynecol Pathol 2000, 19:314-321.
5. Baak J.P., Mutter G.L., Robboy S., et al. The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system. Cancer 2005, 103:2304-2312.
6. Mutter G.L., Kauderer J., Baak J.P. Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: a Gynecologic Oncology Group study. Hum Pathol 2008, 39:866-874. Gynecologic Oncology Group.
7. Kurman R.J., Kaminski P.F., Norris H.J. The behavior of endometrial hyperplasia. a long-term study of "untreated" hyperplasia in 170 patients. Cancer 1985, 56:403-412.
8. Orbo A., Rise C.E., Mutter G.L. Regression of latent endometrial precancers by progestin infiltrated intrauterine device. Cancer Res 2006, 66:5613-5617.
9. Zheng W., Baker H.E., Mutter G.L. Involution of PTEN-null endometrial glands with progestin therapy. Gynecol Oncol 2004, 92:1008-1013.
10. Signorelli M., Caspani G., Bonazzi C., et al. Fertility-sparing treatment in young women with endometrial cancer or atypical complex hyperplasia: a prospective single-institution experience of 21 cases. Br J Obstet Gynaecol 2009, 116:114-118.
11. Wheeler D.T., Bristow R.E., Kurman R.J. Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol 2007, 31:988-998.
12. Mutter G.L., Lin M.C., Fitzgerald J.T., et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 2000, 92:924-930.
13. Mutter G.L., Ince T.A., Baak J.P., et al. Molecular identification of latent precancers in histologically normal endometrium. Cancer Res 2001, 61:4311-4314.
14. Monte N.M., Webster K.A., Neuberg D. Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer. Cancer Res 2010, 170:6225-6232.
15. Mutter G.L., Baak J.P., Crum C.P., et al. Endometrial precancer diagnosis by histopathology, clonal analysis, and computerized morphometry. J Pathol 2000, 190:462-469.
16. Mutter G.L., Wada H., Faquin W.C. K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis. Mol Pathol 1999, 52:257-262.
17. Lin M.C., Lomo L., Baak J.P., et al. Squamous morules are functionally inert elements of premalignant endometrial neoplasia. Mod Pathol 2009, 22:167-174.
18. Mutter G.L., Lin M.C., Fitzgerald J.T. Changes in endometrial PTEN expression throughout the human menstrual cycle. J Clin Endocrinol Metab 2000, 85:2334-2338.
19. Mutter G.L. Endometrial intraepithelial neoplasia (EIN): will it bring order to chaos?. The Endometrial Collaborative Group. Gynecol Oncol 2000, 76:287-290.
20. Hopfer H., Rinehart C.A., Vollmer G. In vitro interactions of endometrial stromal and epithelial cells in matrigel: reorganization of the extracellular matrix. Pathobiology 1994, 62:104-108.
21. Osteen K.G., Rodgers W.H., Gaire M., et al. Stromal-epithelial interaction mediates steroidal regulation of metalloproteinase expression in human endometrium. Proc Natl Acad Sci U S A 1994, 91:10129-10133.
22. Carlson J.W., Mutter G.L. Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change. Histopathology 2008, 53:325-332.
23. Mutter G.L., Zaino R.J., Baak J.P. Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol 2007, 26:103-114.
24. Huang E.C., Mutter G.L., Crum C.P., et al. Clinical outcome in diagnostically ambiguous foci of "gland crowding" in the endometrium. Mod Pathol 30 July 2010, Epub ahead of print.
25. Zheng W., Khurana R., Farahmand S., et al. p53 immunostaining as a significant adjunct diagnostic method for uterine surface carcinoma: precursor of uterine papillary serous carcinoma. Am J Surg Pathol 1998, 22:1463-1473.
26. Yan Z., Parkash V., Zheng W., et al. Minimal uterine serous carcinoma with extrauterine tumor of identical morphology: a study of 13 cases. Lab Invest 2003, 83:216A.
27. Zheng W., Liang S.X., Yu H., et al. Endometrial glandular dysplasia: a newly defined precursor lesion of uterine papillary serous carcinoma. part I: Morphologic features. Int J Surg Pathol 2004, 12:207-223.