Angiotensin II type 1 receptor (AT-1R) expression correlates with VEGF-A and VEGF-D expression in invasive ductal breast cancer

Pathology and Oncology Research

Volumn 18, Issue 4, 2012, Pages 867-873

  Jethon, Aleksandra ^a   Pula, Bartosz ^a   Piotrowska, Aleksandra ^a   Wojnar, Andrzej ^b   Rys, Janusz ^c   Dziegiel, Piotr ^a,b,d   Podhorska Okolow, Marzena ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b Silesian Oncological Centre   (Poland)

^c INSTITUTE OF ONCOLOGY   (Poland)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Angiogenesis; Angiotensin receptors; Breast cancer; Lymphangiogenesis; VEGF

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CD31 ANTIGEN; VASCULOTROPIN A; VASCULOTROPIN C; VASCULOTROPIN D;

ADULT; ARTICLE; BREAST CARCINOMA; CANCER LOCALIZATION; CANCER SURVIVAL; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPHANGIOGENESIS; MOLECULAR PATHOLOGY; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; TUMOR VASCULARIZATION; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPHANGIOGENESIS; MIDDLE AGED; RECEPTOR, ANGIOTENSIN, TYPE 1; STATISTICS, NONPARAMETRIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

EID: 84868456855     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-012-9516-x     Document Type: Article

References (45)

1. Ferlay J, Shin H-R, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893-2917
2. Cuzick J (2010) Breast cancer prevention in the developing world. Breast Cancer Res 12:S9
3. Chappell M (2010) Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin-angiotensin system in inflammation. Arthritis Res Ther 12:128
4. De Paepe B, Verstraeten VL, De Potter CR, Vakaet LA, Bullock GR (2001) Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma. Histochem Cell Biol 116:247-254
5. De Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T (2000) International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 52:415-472
6. Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, Rose JC, Diz DI, Chappell MC (2009) Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol 296:1484-1493
7. Muscella A, Greco S, Elia MG, Storelli C, Marsigliante S (2002) Angiotensin II stimulation of Na+/K + ATPase activity and cell growth by calcium-independent pathway in MCF-7 breast cancer cells. J Endocrinol 173:315-323
8. Tahmasebi M, Barker S, Puddefoot JR, Vinson GP (2006) Localisation of renin-angiotensin system (RAS) components in breast. Br J Cancer 95:67-74
9. Steckelings UM, Kaschina E, Unger T (2005) The AT2 receptor - a matter of love and hate. Peptides 26:1401-1409
10. Bonnet F, Cao Z, Cooper ME (2001) Apoptosis and angiotensin II: yet another renal regulatory system? Exp Nephrol 9:295-300
11. Deshayes F, Nahmias C (2005) Angiotensin receptors: a new role in cancer? Trends Endocrinol Metabol 16:293-299
12. Fujimoto Y, Sasaki T, Tsuchida A, Chayama K (2001) Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist. FEBS Letters 495:197-200
13. Goldfarb DA, Diz DI, Tubbs RR, Ferrario CM, Novick AC (1994) Angiotensin II receptor subtypes in the human renal cortex and renal cell carcinoma. J Urol 151:208-213
14. Batra VK, Gopalakrishnan V, McNeill JR, Hickie RA (1994) Angiotensin II elevates cytosolic free calcium in human lung adenocarcinoma cells via activation of AT1 receptors. Cancer Lett 76:19-24
15. Inwang ER, Puddefoot JR, Brown CL, Goode AW, Marsigliante S, Ho MM, Payne JG, Vinson GP (1997) Angiotensin II type 1 receptor expression in human breast tissues. Br J Cancer 75:1279-1283
16. Greco S, Elia MG, Muscella A, Storelli C, Marsigliante S (2002) AT1 angiotensin II receptor mediates intracellular calcium mobilization in normal and cancerous breast cells in primary culture. Cell Calcium 32:1-10
17. Suzuki Y, Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Egido J (2003) Inflammation and angiotensin II. Int J Biochem Cell Biol 35:881-900
18. Puddefoot JR, Udeozo UK, Barker S, Vinson GP (2006) The role of angiotensin II in the regulation of breast cancer cell adhesion and invasion. Endocr Relat Cancer 13:895-903
19. Herr D, Rodewald M, Fraser HM, Hack G, Konrad R, Kreienberg R, Wulff C (2008) Potential role of Renin-Angiotensin-system for tumor angiogenesis in receptor negative breast cancer. Gynecol Oncol 109:418-425
20. Suganuma T, Ino K, Shibata K, Kajiyama H, Nagasaka T, Mizutani S, Kikkawa F (2005) Functional expression of the angiotensin II type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination. Clin Cancer Res 11:2686-2694
21. Khakoo AY, Sidman RL, Pasqualini R, Arap W (2008) Does the renin-angiotensin system participate in regulation of human vasculogenesis and angiogenesis? Cancer Res 68:9112-9115
22. Fox SB, Gasparini G, Harris AL (2001) Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs. Lancet Oncol 2:278-289
23. Imanishi T, Hano T, Nishio I (2004) Angiotensin II potentiates vascular endothelial growth factor-induced proliferation and network formation of endothelial progenitor cells. Hypertens Res 27:101-108
24. Wasa J, Sugiura H, Kozawa E, Kohyama K, Yamada K, Taguchi O (2011) The tumor suppressive effect of angiotensin II type 1 receptor antagonist in a murine osteosarcoma model. Anticancer Res 31:123-127
25. Gomulkiewicz A, Podhorska-Okolow M, Szulc R, Smorag Z, Wojnar A, Zabel M, Dziegiel P (2010) Correlation between metallothionein (MT) expression and selected prognostic factors in ductal breast cancers. Folia Histochem Cytobiol 48:242-248
26. Remmele W, Stegner HE (1987) Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe 8:138-40
27. Willis LM, El-Remessy AB, Somanath PR, Deremer DL, Fagan SC (2011) Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence. Clin Sci 120:307-319
28. Greco S,Muscella A, EliaMG, Salvatore P, Storelli C, Marsigliante S (2002) Activation of angiotensin II type I receptor promotes protein kinase C translocation and cell proliferation in human cultured breast epithelial cells. J Endocrinol 174:205-214
29. Rhodes DR, Ateeq B, Cao Q, Tomlins SA, Mehra R, Laxman B, Kalyana-Sundaram S, Lonigro RJ, Helgeson BE, Bhojani MS, Rehemtulla A, Kleer CG, Hayes DF, Lucas PC, Varambally S, Chinnaiyan AM (2009) AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist. Proc Natl Acad Sci U S A 106:10284-10289
30. Kosugi M, Miyajima A, Kikuchi E, Kosaka T, Horiguchi Y, Murai M (2007) Effect of angiotensin II type 1 receptor antagonist on tumor growth and angiogenesis in a xenograft model of human bladder cancer. Human Cell 20:1-9
31. Imai N, Hashimoto T, Kihara M, Yoshida S, Kawana I, Yazawa T, Kitamura H, Umemura S (2006) Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis. Lab Invest 87:189-198
32. Fujita M, Hayashi I, Yamashina S, Fukamizu A, Itoman M, Majima M (2005) Angiotensin type 1a receptor signalingdependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth. Carcinogenesis 26:271-279
33. Noguchi R, Yoshiji H, Ikenaka Y, Namisaki T, Kitade M, Kaji K, Yoshii J, Yanase K, Yamazaki M, Tsujimoto T, Kawaratani H, Fukui H (2009) Synergistic inhibitory effect of gemcitabine and angiotensin type-1 receptor blocker, losartan, on murine pancreatic tumor growth via anti-angiogenic activities. Oncol Rep 22:355-360
34. Gu Y, Qi X, Guo S (2008) Lymphangiogenesis induced by VEGFC and VEGF-D promotes metastasis and a poor outcome in breast carcinoma: a retrospective study of 61 cases. Clin Exp Metastasis 25:717-725
35. Mohammed RAA, Green A, El-Shikh S, Paish EC, Ellis IO, Martin SG (2007) Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis. Br J Cancer 96:1092-1100
36. Mylona E, Nomikos A, Alexandrou P, Giannopoulou I, Keramopoulos A, Nakopoulou L (2007) Lymphatic and blood vessel morphometry in invasive breast carcinomas: relation with proliferation and VEGF-C and -D proteins expression. Histol Histopathol 22:825-835
37. Gisterek I, Matkowski R, Koźlak J, Duś D, Łacko A, Szelachowska J, Kornafel J (2007) Evaluation of prognostic value of VEGF-C and VEGF-D in breast cancer - 10 years follow-up analysis. Anticancer Res 27:2797-2802
38. Mylona E, Alexandrou P, Mpakali A, Giannopoulou I, Liapis G, Markaki S, Keramopoulos A, Nakopoulou L (2007) Clinicopathological and prognostic significance of vascular endothelial growth factors (VEGF)-C and -D and VEGF receptor 3 in invasive breast carcinoma. Eur J Surg Oncol 33:294-300
39. van der Schaft DWJ, Pauwels P, Hulsmans S, Zimmermann M, van de Poll-Franse LV, Griffioen AW (2007) Absence of lymphangiogenesis in ductal breast cancer at the primary tumor site. Cancer Lett 254:128-136
40. Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-348
41. Eubank TD, Roberts RD, Khan M, Curry JM, Nuovo GJ, Kuppusamy P, Marsh CB (2009) Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages. Cancer Res 69:2133-2140
42. Joimel U, Gest C, Soria J, Pritchard LL, Alexandre J, Laurent M, Blot E, Cazin L, Vannier JP, Varin R, Li H, Soria C (2010) Stimulation of angiogenesis resulting from cooperation between macrophages and MDA-MB-231 breast cancer cells: proposed molecular mechanism and effect of tetrathiomolybdate. BMC Cancer 10:375
43. Lambert DW, Clarke NE, Turner AJ (2010) Not just angiotensinases: new roles for the angiotensin-converting enzymes. Cell Mol Life Sci 67:89-98
44. González-Zuloeta Ladd AM, Arias Vásquez A, Sayed-Tabatabaei FA, Coebergh JW, Hofman A, Njajou O, Stricker B, van Duijn C (2005) Angiotensin-converting enzyme gene insertion/deletion polymorphism and breast cancer risk. Cancer Epidemiol Biomarkers Prev 14:2143-2146
45. González-Zuloeta Ladd AM, Arias Vásquez A, Siemes C, Yazdanpanah M, Coebergh JW, Hofman A, Stricker BH, van Duijn CM (2007) Differential roles of angiotensinogen and angiotensin receptor type 1 polymorphisms in breast cancer risk. Breast Cancer Res Treat 10:299-304