Absence of lymphangiogenesis in ductal breast cancer at the primary tumor site

Cancer Letters

Volumn 254, Issue 1, 2007, Pages 128-136

  van der Schaft, Daisy W J ^a   Pauwels, Patrick ^b   Hulsmans, Sarah ^a   Zimmermann, Miriam ^a   van de Poll Franse, Lonneke V ^c   Griffioen, Arjan W ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c The Netherlands   (Netherlands)

Author keywords

Ductal breast cancer; Lymphangiogenesis; Lymphatic vessel invaded tumor cells; Prognosis; VEGF C and D

Indexed keywords

KI 67 ANTIGEN; PODOPLANIN; VASCULOTROPIN C; VASCULOTROPIN D;

ADULT; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPHANGIOGENESIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR LOCALIZATION;

AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; KI-67 ANTIGEN; LYMPHANGIOGENESIS; LYMPHATIC VESSELS; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROGNOSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

ANIMALIA;

EID: 34447324656     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.03.001     Document Type: Article

References (30)

1. Folkman J. Angiogenesis. Annu. Rev. Med. 57 (2006) 1-18
2. Griffioen A.W., and Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 52 2 (2000) 237-268
3. van der Schaft D.W., Dings R.P., de Lussanet Q.G., van Eijk L.I., Nap A.W., Beets-Tan R.G., Bouma-Ter Steege J.C., Wagstaff J., Mayo K.H., and Griffioen A.W. The designer anti-angiogenic peptide anginex targets tumor endothelial cells and inhibits tumor growth in animal models. FASEB J. 16 14 (2002) 1991-1993
4. Hurwitz H., Fehrenbacher L., Novotny W., Cartwright T., Hainsworth J., Heim W., Berlin J., Baron A., Griffing S., Holmgren E., Ferrara N., Fyfe G., Rogers B., Ross R., and Kabbinavar F. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350 23 (2004) 2335-2342
5. Skobe M., Hawighorst T., Jackson D.G., Prevo R., Janes L., Velasco P., Riccardi L., Alitalo K., Claffey K., and Detmar M. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat. Med. 7 2 (2001) 192-198
6. Mattila M.M., Ruohola J.K., Karpanen T., Jackson D.G., Alitalo K., and Harkonen P.L. VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int. J. Cancer 98 6 (2002) 946-951
7. Stacker S.A., Caesar C., Baldwin M.E., Thornton G.E., Williams R.A., Prevo R., Jackson D.G., Nishikawa S., Kubo H., and Achen M.G. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat. Med. 7 2 (2001) 186-191
8. Williams C.S., Leek R.D., Robson A.M., Banerji S., Prevo R., Harris A.L., and Jackson D.G. Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer. J. Pathol. 200 2 (2003) 195-206
9. Clarijs R., Ruiter D.J., and de Waal R.M. Lymphangiogenesis in malignant tumours: does it occur?. J. Pathol. 193 2 (2001) 143-146
10. Saharinen P., Tammela T., Karkkainen M.J., and Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol. 25 7 (2004) 387-395
11. Kaipainen A., Korhonen J., Mustonen T., van Hinsbergh V.W., Fang G.H., Dumont D., Breitman M., and Alitalo K. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Natl. Acad. Sci. USA 92 8 (1995) 3566-3570
12. Rodriguez-Niedenfuhr M., Papoutsi M., Christ B., Nicolaides K.H., von Kaisenberg C.S., Tomarev S.I., and Wilting J. Prox1 is a marker of ectodermal placodes, endodermal compartments, lymphatic endothelium and lymphangioblasts. Anat. Embryol. (Berl.) 204 5 (2001) 399-406
13. Banerji S., Ni J., Wang S.X., Clasper S., Su J., Tammi R., Jones M., and Jackson D.G. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol. 144 4 (1999) 789-801
14. Breiteneder-Geleff S., Soleiman A., Kowalski H., Horvat R., Amann G., Kriehuber E., Diem K., Weninger W., Tschachler E., Alitalo K., and Kerjaschki D. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am. J. Pathol. 154 2 (1999) 385-394
15. Vleugel M.M., Bos R., van der Groep P., Greijer A.E., Shvarts A., Stel H.V., van der Wall E., and van Diest P.J. Lack of lymphangiogenesis during breast carcinogenesis. J. Clin. Pathol. 57 7 (2004) 746-751
16. Schoppmann S.F., Bayer G., Aumayr K., Taucher S., Geleff S., Rudas M., Kubista E., Hausmaninger H., Samonigg H., Gnant M., Jakesz R., and Horvat R. Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Ann. Surg. 240 2 (2004) 306-312
17. Bono P., Wasenius V.M., Heikkila P., Lundin J., Jackson D.G., and Joensuu H. High LYVE-1-positive lymphatic vessel numbers are associated with poor outcome in breast cancer. Clin. Cancer Res. 10 21 (2004) 7144-7149
18. Agarwal B., Saxena R., Morimiya A., Mehrotra S., and Badve S. Lymphangiogenesis does not occur in breast cancer. Am. J. Surg. Pathol. 29 11 (2005) 1449-1455
19. Nakamura Y., Yasuoka H., Tsujimoto M., Imabun S., Nakahara M., Nakao K., Nakamura M., Mori I., and Kakudo K. Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer. Breast Cancer Res. Treat. 91 2 (2005) 125-132
20. Choi W.W., Lewis M.M., Lawson D., Yin-Goen Q., Birdsong G.G., Cotsonis G.A., Cohen C., and Young A.N. Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression. Mod. Pathol. 18 1 (2005) 143-152
21. Bando H., Weich H.A., Horiguchi S., Funata N., Ogawa T., and Toi M. The association between vascular endothelial growth factor-C, its corresponding receptor, VEGFR-3, and prognosis in primary breast cancer: a study with 193 cases. Oncol. Rep. 15 3 (2006) 653-659
22. Longatto Filho A., Martins A., Costa S.M., and Schmitt F.C. VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels. Pathol. Res. Pract. 201 2 (2005) 93-99
23. Nakamura Y., Yasuoka H., Tsujimoto M., Yang Q., Imabun S., Nakahara M., Nakao K., Nakamura M., Mori I., and Kakudo K. Flt-4-positive vessel density correlates with vascular endothelial growth factor-d expression, nodal status, and prognosis in breast cancer. Clin. Cancer Res. 9 14 (2003) 5313-5317
24. Al-Rawi M.A., Watkins G., Mansel R.E., and Jiang W.G. Interleukin 7 upregulates vascular endothelial growth factor D in breast cancer cells and induces lymphangiogenesis in vivo. Br. J. Surg. 92 3 (2005) 305-310
25. Vleugel M.M., Bos R., Buerger H., van der Groep P., Saramaki O.R., Visakorpi T., van der Wall E., and van Diest P.J. No amplifications of hypoxia-inducible factor-1alpha gene in invasive breast cancer: a tissue microarray study. Cell Oncol. 26 5-6 (2004) 347-351
26. Van den Eynden G.G., Van der Auwera I., Van Laere S.J., Huygelen V., Colpaert C.G., van Dam P., Dirix L.Y., Vermeulen P.B., and Van Marck E.A. Induction of lymphangiogenesis in and around axillary lymph node metastases of patients with breast cancer. Br. J. Cancer 95 10 (2006) 1362-1366
27. Akahane M., Akahane T., Matheny S.L., Shah A., Okajima E., and Thorgeirsson U.P. Vascular endothelial growth factor-D is a survival factor for human breast carcinoma cells. Int. J. Cancer 118 4 (2006) 841-849
28. Akahane M., Akahane T., Shah A., Okajima E., and Thorgeirsson U.P. A potential role for vascular endothelial growth factor-D as an autocrine growth factor for human breast carcinoma cells. Anticancer Res. 25 2A (2005) 701-707
29. Bouma-ter Steege J.C., Baeten C.I., Thijssen V.L., Satijn S.A., Verhoeven I.C., Hillen H.F., Wagstaff J., and Griffioen A.W. Angiogenic profile of breast carcinoma determines leukocyte infiltration. Clin. Cancer Res. 10 21 (2004) 7171-7178
30. Currie M.J., Hanrahan V., Gunningham S.P., Morrin H.R., Frampton C., Han C., Robinson B.A., and Fox S.B. Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1alpha) and the HIF-1alpha target gene DEC1, but not lymph node metastasis in primary human breast carcinomas. J. Clin. Pathol. 57 8 (2004) 829-834