Mechanism and regulation of vitamin B2 (riboflavin) uptake by mouse and human pancreatic β-cells/islets: Physiological and molecular aspects

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 303, Issue 9, 2012, Pages

  Ghosal, Abhisek ^a,b   Said, Hamid M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Pancreatic cells; Riboflavin; Uptake mechanism; Uptake regulation

Indexed keywords

CALCIUM; CALMODULIN; RIBOFLAVIN; SMALL INTERFERING RNA; SODIUM; TRITIUM;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG UPTAKE; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; BIOLOGICAL TRANSPORT; CALMODULIN; CELL LINE; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MEMBRANE TRANSPORT PROTEINS; MICE; NERVE TISSUE PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RIBOFLAVIN; RIBOFLAVIN DEFICIENCY; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VITAMIN B COMPLEX;

EID: 84868381584     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00314.2012     Document Type: Article

References (37)

1. Betz AL, Ren XD, Ennis SR, Hultquist DE. Riboflavin reduces edema in focal cerebral ischemia. Acta Neurochir Suppl (Wien) 60: 314-317, 1994.
2. Bonjour JP. Vitamins and alcoholism. V. Riboflavin, VI. Niacin, VII. Pantothenic acid, and VIII. Biotin. Int J Vitam Nutr Res 50: 425-440, 1980.
3. Brandsch M, Miyamoto Y, Ganapathy V, Leibach FH. Regulation of taurine transport in human colon carcinoma cell lines (HT-29 and Caco-2) by protein kinase C. Am J Physiol Gastrointest Liver Physiol 264: G939-G946, 1993.
4. Cai F, Li CR, Wu JL, Chen JG, Liu C, Min Q, Yu W, Ouyang CH, Chen JH. Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. Mediators Inflamm 2006: 30490, 2006.
5. Cobianchi L, Fornoni A, Pileggi A, Molano RD, Sanabria NY, Gonzalez-Quintana J, Bocca N, Marzorati S, Zahr E, Hogan AR, Ricordi C, Inverardi L. Riboflavin inhibits IL-6 expression and p38 activation in islet cells. Cell Transplant 17: 559-566, 2008.
6. 2+/calmodulin-dependent protein kinase II, a brush border membrane protein. Proc Natl Acad Sci U S A 87: 8990-8994, 1990.
7. Cooperman JM, Lopez R. (Editors). Riboflavin. In: Handbook of Vitamins: Nutrional, Biochemical and Clinical Aspects. New York: Dekker, 1984, p. 299-327.
8. + exchange. Am J Physiol Gastrointest Liver Physiol 266: G647-G656, 1994.
9. Elferink CJ, Reiners JJ Jr. Quantitative RT-PCR on CYP1A1 heterogeneous nuclear RNA: a surrogate for the in vitro transcription run-on assay. Biotechniques 20: 470-477, 1996.
10. Fennelly J, Frank O, Baker H, Leevy CM. Peripheral neuropathy of the alcoholic. I. Aetiological role of aneurin and other B-complex vitamins. Br Med J 2: 1290-1292, 1964.
11. Fernandez-Banares F, Abad-Lacruz A, Xiol X, Gine JJ, Dolz C, Cabre E, Esteve M, Gonzalez-Huix F, Gassull MA. Vitamin status in patients with inflammatory bowel disease. Am J Gastroenterol 84: 744-748, 1989.
12. Goldsmith GA. Riboflavin deficiency. In: Riboflavin. New York: Plenum, 1975, p. 221-244.
13. Iwanaga K, Hasegawa T, Hultquist DE, Harada H, Yoshikawa Y, Yanamadala S, Liao H, Visovatti SH, Pinsky DJ. Riboflavin-mediated reduction of oxidant injury, rejection, and vasculopathy after cardiac allotransplantation. Transplantation 83: 747-753, 2007.
14. Kodentsova VM, Vrzhesinskaia OA, Sokol'nikov AA, Alekseeva IA, Spirichev VB. [Metabolism of riboflavin and B group vitamins functionally bound to it in insulin-dependent diabetes mellitus]. Vopr Med Khim 39: 33-36, 1993.
15. Kodentsova VM, Vrzhesinskaia OA, Trofimenko EV, Sokol'nikov AA, Beketova NA, Blazheevich NV, Isaeva VA, Aleinik SI, Trofimenko LS, Dronova VI, et al. [Vitamin status of children with diabetes mellitus]. Vopr Med Khim 40: 45-48, 1994.
16. Kumar CK, Yanagawa N, Ortiz A, Said HM. Mechanism and regulation of riboflavin uptake by human renal proximal tubule epithelial cell line HK-2. Am J Physiol Renal Physiol 274: F104-F110, 1998.
17. Law LK, Tang NL, Hui J, Fung SL, Ruiter J, Wanders RJ, Fok TF, Lam CW. Novel mutations in ETFDH gene in Chinese patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency. Clin Chim Acta 404: 95-99, 2009.
18. Liang WC, Ohkuma A, Hayashi YK, Lopez LC, Hirano M, Nonaka I, Noguchi S, Chen LH, Jong YJ, Nishino I. ETFDH mutations, CoQ10 levels, and respiratory chain activities in patients with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency. Neuromuscul Disord 19: 212-216, 2009.
19. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2[-delta delta C(T)] method. Methods 25: 402-408, 2001.
20. Mack CP, Hultquist DE, Shlafer M. Myocardial flavin reductase and riboflavin: a potential role in decreasing reoxygenation injury. Biochem Biophys Res Commun 212: 35-40, 1995.
21. Majumdar SK, Shaw GK, Thomson AD. Vitamin utilization status in chronic alcoholics. Int J Vitam Nutr Res 51: 54-58, 1981.
22. Mee L, Nabokina SM, Sekar VT, Subramanian VS, Maedler K, Said HM. Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations. Am J Physiol Gastrointest Liver Physiol 297: G197-G206, 2009.
23. Piper RC, James DE, Slot JW, Puri C, Lawrence JC Jr. GLUT4 phosphorylation and inhibition of glucose transport by dibutyryl cAMP. J Biol Chem 268: 16557-16563, 1993.
24. +/calmodulin-mediated process. J Clin Invest 82: 1091-1097, 1988.
25. Rosenthal WS, Adham NF, Lopez R, Cooperman JM. Riboflavin deficiency in complicated chronic alcoholism. Am J Clin Nutr 26: 858-860, 1973.
26. Ryu DY, Levi PE, Fernandez-Salguero P, Gonzalez FJ, Hodgson E. Piperonyl butoxide and acenaphthylene induce cytochrome P450 1A2 and 1B1 mRNA in aromatic hydrocarbon-responsive receptor knock-out mouse liver. Mol Pharmacol 50: 443-446, 1996.
27. Said HM, Ma TY, Grant K. Regulation of riboflavin intestinal uptake by protein kinase A: studies with Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 267: G955-G959, 1994.
28. Said HM, Ortiz A, Ma TY, McCloud E. Riboflavin uptake by the human-derived liver cells Hep G2: mechanism and regulation. J Cell Physiol 176: 588-594, 1998.
29. Said HM, Ortiz A, Moyer MP, Yanagawa N. Riboflavin uptake by human-derived colonic epithelial NCM460 cells. Am J Physiol Cell Physiol 278: C270-C276, 2000.
30. Seekamp A, Hultquist DE, Till GO. Protection by vitamin B2 against oxidant-mediated acute lung injury. Inflammation 23: 449-460, 1999.
31. Subramanian VS, Subramanya SB, Said HM. Chronic alcohol exposure negatively impacts the physiological and molecular parameters of the renal biotin reabsorption process. Am J Physiol Renal Physiol 300: F611-F617, 2011.
32. Subramanian VS, Subramanya SB, Tsukamoto H, Said HM. Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport. Am J Physiol Renal Physiol 299: F28-F34, 2010.
33. Toyosawa T, Suzuki M, Kodama K, Araki S. Highly purified vitamin B2 presents a promising therapeutic strategy for sepsis and septic shock. Infect Immun 72: 1820-1823, 2004.
34. Tu BP, Ho-Schleyer SC, Travers KJ, Weissman JS. Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science 290: 1571-1574, 2000.
35. Yamamoto S, Inoue K, Ohta KY, Fukatsu R, Maeda JY, Yoshida Y, Yuasa H. Identification and functional characterization of rat riboflavin transporter 2. J Biochem 145: 437-443, 2009.
36. Yao Y, Yonezawa A, Yoshimatsu H, Masuda S, Katsura T, Inui K. Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain. J Nutr 140: 1220-1226, 2010.
37. Yonezawa A, Masuda S, Katsura T, Inui K. Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1. Am J Physiol Cell Physiol 295: C632-C641, 2008.