Enamel matrix derivative in intrabony defects: Prognostic parameters of clinical and radiographic treatment outcomes

Journal of Periodontology

Volumn 83, Issue 11, 2012, Pages 1346-1352

  Parashis, Andreas O ^a,b   Polychronopoulou, Argy ^c   Tsiklakis, Konstantinos ^c   Tatakisi, Dimitris N ^d,e  

^a Private Practice   (Greece)

^b TUFTS UNIVERSITY SCHOOL OF DENTAL MEDICINE   (United States)

^c UNIVERSITY OF ATHENS   (Greece)

^d OHIO STATE UNIVERSITY   (United States)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Alveolar bone loss; Dental enamel proteins; Intrabony defects; Periodontal regeneration; Periodontal surgery; Periodontitis

Indexed keywords

EID: 84868364140     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2012.110551     Document Type: Article

References (43)

1. Vrotsos JA, Parashis AO, Theofanatos GD, Smulow JB. Prevalence and distribution of bone defects in moderate and advanced adult periodontitis. J Clin Periodontol 1999;26:44-48.
2. Papapanou PN, Wennstrom JL. The angular bony defect as indicator of further alveolar bone loss. J Clin Periodontol 1991;18:317-322.
3. CarnevaleG, CairoF,Nieri M, TonettiMS. Fibre retention osseous resective surgery: How deep is the infrabony component of the osseous-resected defects? J Clin Periodontol 2008;35:133-138.
4. Murphy KG, Gunsolley JC. Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review. Ann Periodontol 2003;8: 266-302.
5. Heijl L, Heden G, Svardstrom G, Ostgren A. Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol 1997; 24:705-714.
6. Parashis A, Tsiklakis K. Clinical and radiographic findings following application of enamel matrix derivative in the treatment of intrabony defects. A series of case reports. J Clin Periodontol 2000;27:705-713.
7. Trombelli L, Farina R. Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration. J Clin Periodontol 2008;35(Suppl. 8):117-135.
8. Esposito M, Grusovin MG, Papanikolaou N, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. Cochrane Database Syst Rev 2009;4:CD003875.
9. Aichelmann-Reidy ME, Reynolds MA. Predictability of clinical outcomes following regenerative therapy in intrabony defects. J Periodontol 2008;79:387-393.
10. Claffey N, Egelberg J. Clinical characteristics of periodontal sites with probing attachment loss following initial periodontal treatment. J Clin Periodontol 1994; 21:670-679.
11. Matuliene G, Pjetursson BE, Salvi GE, et al. Influence of residual pockets on progression of periodontitis and tooth loss: Results after 11 years of maintenance. J Clin Periodontol 2008;35:685-695.
12. Caton JG. Overview of clinical trials on periodontal regeneration. Ann Periodontol 1997;2:215-222.
13. Garrett S. Periodontal regeneration around natural teeth. Ann Periodontol 1996;1:621-666.
14. Kornman KS, Robertson PB. Fundamental principles affecting the outcomes of therapy for osseous lesions. Periodontol 2000 2000;22:22-43.
15. Laurell L, Gottlow J, Zybutz M, Persson R. Treatment of intrabony defects by different surgical procedures. A literature review. J Periodontol 1998;69:303-313.
16. Wang HL, Greenwell H, Fiorellini J, et al; Research, Science and Therapy Committee. Periodontal regeneration. J Periodontol 2005;76:1601-1622.
17. Tonetti MS, Lang NP, Cortellini P, et al. Enamel matrix proteins in the regenerative therapy of deep intrabony defects. J Clin Periodontol 2002;29:317-325.
18. Siciliano VI, Andreuccetti G, Siciliano AI, Blasi A, Sculean A, Salvi GE. Clinical outcomes after treatment of non-contained intrabony defects with enamel matrix derivative or guided tissue regeneration: A 12-month randomized controlled clinical trial. J Periodontol 2011; 82:62-71.
19. Tsitoura E, Tucker R, Suvan J, Laurell L, Cortellini P, Tonetti M. Baseline radiographic defect angle of the intrabony defect as a prognostic indicator in regenerative periodontal surgery with enamel matrix derivative. J Clin Periodontol 2004;31:643-647.
20. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
21. Silness J, Loe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-135.
22. Parashis AO, Tsiklakis K, Tatakis DN. EDTA gel root conditioning: Lack of effect on clinical and radiographic outcomes of intrabony defect treatment with enamel matrix derivative. J Periodontol 2006;77:103-110.
23. Sculean A, Berakdar M, Willershausen B, Arweiler NB, Becker J, Schwarz F. Effect of EDTA root conditioning on the healing of intrabony defects treated with an enamel matrix protein derivative. J Periodontol 2006; 77:1167-1172.
24. Loe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963; 21:533-551.
25. Van der Stelt PF. Modern radiographic methods in the diagnosis of periodontal disease. Adv Dent Res 1993; 7:158-162.
26. Tsiklakis K, van der Stelt PF, Parashis A. Projective reconstruction of non-standardized radiographs in digital subtraction radiography. Dentomaxillofac Radiol 1995;24:105-106.
27. Steffensen B, Webert HP. Relationship between the radiographic periodontal defect angle and healing after treatment. J Periodontol 1989;60:248-254.
28. Tonetti MS, Pini-Prato G, Cortellini P. Periodontal regeneration of human intrabony defects. IV. Determinants of healing response. J Periodontol 1993;64:934-940.
29. Schei O, Waerhaug J, Lovdal I, Arno A. Alveolar bone loss as related to oral hygiene and age. J Periodontol 1959;30:7-16.
30. Bjorn H, Halling A, Thyberg H. Radiographic assessment of marginal bone loss. Odontol Revy 1969;20: 165-179.
31. Waerhaug J. Healing of the dento-epithelial junction following subgingival plaque control. II: As observed on extracted teeth. J Periodontol 1978;49:119-134.
32. Rabbani GM, Ash MM Jr., Caffesse RG. The effectiveness of subgingival scaling and root planing in calculus removal. J Periodontol 1981;52:119-123.
33. Cortellini P, Prato GP, Tonetti MS. The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures. J Periodontol 1995;66:261-266.
34. Cortellini P, Prato GP, Tonetti MS. The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures. Int J Periodontics Restorative Dent 1999; 19:589-599.
35. Wachtel H, Schenk G, BohmS, Weng D, Zuhr O, Hurzeler MB. Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: A controlled clinical study. J Clin Periodontol 2003;30: 496-504.
36. Sculean A, Chiantella GC, Windisch P, Gera I, Reich E. Clinical evaluation of an enamel matrix protein derivative (Emdogain) combined with a bovine-derived xenograft (Bio-Oss) for the treatment of intrabony periodontal defects in humans. Int J Periodontics Restorative Dent 2002;22:259-267.
37. Cortellini P, Pini-Prato G, Nieri M, Tonetti MS. Minimally invasive surgical technique and enamel matrix derivative in intrabony defects: 2. Factors associated with healing outcomes. Int J Periodontics Restorative Dent 2009;29:257-265.
38. Heden G. A case report study of 72 consecutive Emdogain- treated intrabony periodontal defects: Clinical and radiographic findings after 1 year. Int J Periodontics Restorative Dent 2000;20:127-139.
39. Klein F, Kim TS, Hassfeld S, et al. Radiographic defect depth and width for prognosis and description of periodontal healing of infrabony defects. J Periodontol 2001; 72:1639-1646.
40. Heden G, Wennstrom J, Lindhe J. Periodontal tissue alterations following Emdogain treatment of periodontal sites with angular bone defects. A series of case reports. J Clin Periodontol 1999;26:855-860.
41. Cortellini P, Tonetti MS. Long-term tooth survival following regenerative treatment of intrabony defects. J Periodontol 2004;75:672-678.
42. Patel RA, Wilson RF, Palmer RM. The effect of smoking on periodontal bone regeneration: A systematic review and meta-analysis. J Periodontol 2012;83:143-155.
43. Sloan A, Hussain I, Maqsood M, Eremin O, El-Sheemy M. The effects of smoking on fracture healing. Surgeon 2010;8:111-116.