The effects of smoking on fracture healing

Surgeon

Volumn 8, Issue 2, 2010, Pages 111-116

  Sloan, A ^a   Hussain, I ^a   Maqsood, M ^b   Eremin, O ^b   El Sheemy, M ^a,b  

^a UNIVERSITY OF LINCOLN   (United Kingdom)

^b LINCOLN COUNTY HOSPITAL   (United Kingdom)

Author keywords

Acute phase proteins tobacco smoking; Delayed union; Fracture healing; Mesenchymal stem cells

Indexed keywords

NICOTINE; NICOTINIC AGENT;

ANIMAL; FIBROBLAST; FRACTURE HEALING; HUMAN; MICROTUBULE; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SMOKE; SMOKING;

ANIMALS; FIBROBLASTS; FRACTURE HEALING; HUMANS; MICROTUBULES; NICOTINE; NICOTINIC AGONISTS; SMOKE; SMOKING;

EID: 77649234571     PISSN: 1479666X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surge.2009.10.014     Document Type: Review

References (74)

1. Wipfli H., and Samet J.M. Global economic and health benefits of tobacco control: part 1. Clin Pharmacol Ther (2009 Jun 17)
2. Gruer L., Hart C.L., Gordon D.S., and Watt G.C. Effect of tobacco smoking on survival of men and women by social position: a 28 year cohort study. BMJ 338 (2009) b480
3. Porter S.E., and Hanley Jr. E.N. The musculoskeletal effects of smoking. J Am Acad Orthop Surg 9 1 (2001 Jan-Feb) 9-17
4. Bartecchi C.E., MacKenzie T.D., and Schrier R.W. The human costs of tobacco use (1). N Engl J Med 330 13 (1994 Mar 31) 907-912
5. Capewell S., Hayes D.K., Ford E.S., Critchley J.A., Croft J.B., Greenlund K.J., et al. Life-years gained among US adults from modern treatments and changes in the prevalence of 6 coronary heart disease risk factors between 1980 and 2000. Am J Epidemiol (2009 Jun 18)
6. Rees T.D., Liverett D.M., and Guy C.L. The effect of cigarette smoking on skin-flap survival in the face lift patient. Plast Reconstr Surg 73 6 (1984 Jun) 911-915
7. Riefkohl R., Wolfe J.A., Cox E.B., and McCarty Jr. K.S. Association between cutaneous occlusive vascular disease, cigarette smoking, and skin slough after rhytidectomy. Plast Reconstr Surg 77 4 (1986 Apr) 592-595
8. Kroll S.S. Necrosis of abdominoplasty and other secondary flaps after TRAM flap breast reconstruction. Plast Reconstr Surg 94 5 (1994 Oct) 637-643
9. Bailey M.H., Smith J.W., Casas L., Johnson P., Serra E., de la Fuente R., et al. Immediate breast reconstruction: reducing the risks. Plast Reconstr Surg 83 5 (1989 May) 845-851
10. Hartrampf Jr. C.R., and Bennett G.K. Autogenous tissue reconstruction in the mastectomy patient. A critical review of 300 patients. Ann Surg 205 5 (1987 May) 508-519
11. Mosely L.H., and Finseth F. Cigarette smoking: impairment of digital blood flow and wound healing in the hand. Hand 9 2 (1977 Jun) 97-101
12. Pitts K.R., Yoon Y., Krueger E.W., and McNiven M.A. The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Mol Biol Cell 10 12 (1999 Dec) 4403-4417
13. Netscher D.T., and Clamon J. Smoking: adverse effects on outcomes for plastic surgical patients. Plast Surg Nurs 14 4 (1994 Winter) 205-210
14. Nolan J., Jenkins R.A., Kurihara K., and Schultz R.C. The acute effects of cigarette smoke exposure on experimental skin flaps. Plast Reconstr Surg 75 4 (1985 Apr) 544-551
15. Czernin J., and Waldherr C. Cigarette smoking and coronary blood flow. Prog Cardiovasc Dis 45 5 (2003 Mar-Apr) 395-404
16. Frances C., Boisnic S., Hartmann D.J., Dautzenberg B., Branchet M.C., Charpentier Y.L., et al. Changes in the elastic tissue of the non-sun-exposed skin of cigarette smokers. Br J Dermatol 125 1 (1991 Jul) 43-47
17. Akoz T., Akan M., and Yildirim S. If you continue to smoke, we may have a problem: smoking's effects on plastic surgery. Aesthetic Plast Surg 26 6 (2002 Nov-Dec) 477-482
18. Sorensen L.T., Friis E., Jorgensen T., Vennits B., Andersen B.R., Rasmussen G.I., et al. Smoking is a risk factor for recurrence of groin hernia. World J Surg 26 4 (2002 Apr) 397-400
19. Siana J.E., Rex S., and Gottrup F. The effect of cigarette smoking on wound healing. Scand J Plast Reconstr Surg Hand Surg 23 3 (1989) 207-209
20. Wong L.S., and Martins-Green M. Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing. Wound Repair Regen 12 4 (2004 Jul-Aug) 471-484
21. Oe K., Miwa M., Sakai Y., Lee S.Y., Kuroda R., and Kurosaka M. An in vitro study demonstrating that haematomas found at the site of human fractures contain progenitor cells with multilineage capacity. J Bone Joint Surg Br 89 1 (2007 Jan) 133-138
22. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol 200 4 (2003 Jul) 500-503
23. Pryor W.A. Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity. Environ Health Perspect 105 Suppl. 4 (1997 Jun) 875-882
24. Comhair S.A., and Erzurum S.C. Antioxidant responses to oxidant-mediated lung diseases. Am J Physiol Lung Cell Mol Physiol 283 2 (2002 Aug) L246-L255
25. Sherwin M.A., and Gastwirth C.M. Detrimental effects of cigarette smoking on lower extremity wound healing. J Foot Surg 29 1 (1990 Jan-Feb) 84-87
26. Toyooka T., and Ibuki Y. Cigarette sidestream smoke induces phosphorylated histone H2AX. Mutat Res 676 1-2 (2009 May 31) 34-40
27. Hoffmann D., and Hoffmann I. The changing cigarette, 1950-1995. J Toxicol Environ Health 50 4 (1997 Mar) 307-364
28. Zevin S., Gourlay S.G., and Benowitz N.L. Clinical pharmacology of nicotine. Clin Dermatol 16 5 (1998 Sep-Oct) 557-564
29. Hukkanen J., Jacob III P., and Benowitz N.L. Metabolism and disposition kinetics of nicotine. Pharmacol Rev 57 1 (2005 Mar) 79-115
30. Cobb T.K., Gabrielsen T.A., Campbell II D.C., Wallrichs S.L., and Ilstrup D.M. Cigarette smoking and nonunion after ankle arthrodesis. Foot Ankle Int 15 2 (1994 Feb) 64-67
31. Lefkowitz R.J. Editorial: smoking, catecholamines, and the heart. N Engl J Med 295 11 (1976 Sep 9) 615-616
32. Waeber B., Schaller M.D., Nussberger J., Bussien J.P., Hofbauer K.G., and Brunner H.R. Skin blood flow reduction induced by cigarette smoking: role of vasopressin. Am J Phys 247 6 Pt 2 (1984 Dec) H895-H901
33. Winniford M.D., Wheelan K.R., Kremers M.S., Ugolini V., van den Berg Jr. E., Niggemann E.H., et al. Smoking-induced coronary vasoconstriction in patients with atherosclerotic coronary artery disease: evidence for adrenergically mediated alterations in coronary artery tone. Circulation 73 4 (1986 Apr) 662-667
34. Bornmyr S., and Svensson H. Thermography and laser-Doppler flowmetry for monitoring changes in finger skin blood flow upon cigarette smoking. Clin Physiol 11 2 (1991 Mar) 135-141
35. van Adrichem L.N., Hovius S.E., van Strik R., and van der Meulen J.C. Acute effects of cigarette smoking on microcirculation of the thumb. Br J Plast Surg 45 1 (1992 Jan) 9-11
36. Folsom A.R. Epidemiology of fibrinogen. Eur Heart J 16 Suppl. A (1995 Mar) 21-23 discussion 3-4
37. El-Zayadi A.R., Selim O., Hamdy H., El-Tawil A., and Moustafa H. Heavy cigarette smoking induces hypoxic polycythemia (erythrocytosis) and hyperuricemia in chronic hepatitis C patients with reversal of clinical symptoms and laboratory parameters with therapeutic phlebotomy. Am J Gastroenterol 97 5 (2002 May) 1264-1265
38. Seyler Jr. L.E., Pomerleau O.F., Fertig J.B., Hunt D., and Parker K. Pituitary hormone response to cigarette smoking. Pharmacol Biochem Behav 24 1 (1986 Jan) 159-162
39. Seyler Jr. L.E., Fertig J., Pomerleau O., Hunt D., and Parker K. The effects of smoking on ACTH and cortisol secretion. Life Sci 34 1 (1984 Jan 2) 57-65
40. de Vernejoul M.C., Bielakoff J., Herve M., Gueris J., Hott M., Modrowski D., et al. Evidence for defective osteoblastic function. A role for alcohol and tobacco consumption in osteoporosis in middle-aged men. Clin Orthop Relat Res 179 (1983 Oct) 107-115
41. Fang M.A., Frost P.J., Iida-Klein A., and Hahn T.J. Effects of nicotine on cellular function in UMR 106-01 osteoblast-like cells. Bone 12 4 (1991) 283-286
42. Krupski W.C. The peripheral vascular consequences of smoking. Ann Vasc Surg 5 3 (1991 May) 291-304
43. Jorgensen L.N., Kallehave F., Christensen E., Siana J.E., and Gottrup F. Less collagen production in smokers. Surgery 123 4 (1998 Apr) 450-455
44. Leow Y.H., and Maibach H.I. Cigarette smoking, cutaneous vasculature, and tissue oxygen. Clin Dermatol 16 5 (1998 Sep-Oct) 579-584
45. Barnoya J., and Glantz S.A. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation 111 20 (2005 May 24) 2684-2698
46. Sorensen L.T., Jorgensen S., Petersen L.J., Hemmingsen U., Bulow J., Loft S., et al. Acute effects of nicotine and smoking on blood flow, tissue oxygen, and aerobe metabolism of the skin and subcutis. J Surg Res 152 2 (2009 Apr) 224-230
47. Smirnova E., Shurland D.L., Ryazantsev S.N., and van der Bliek A.M. A human dynamin-related protein controls the distribution of mitochondria. J Cell Biol 143 2 (1998 Oct 19) 351-358
48. Frank S., Gaume B., Bergmann-Leitner E.S., Leitner W.W., Robert E.G., Catez F., et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 1 4 (2001 Oct) 515-525
49. Li Y., Dowbenko D., and Lasky L.A. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 277 13 (2002 Mar 29) 11352-11361
50. Helt C.E., Rancourt R.C., Staversky R.J., and O'Reilly M.A. p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity. Toxicol Sci 63 2 (2001 Oct) 214-222
51. Whyte D.A., Broton C.E., and Shillitoe E.J. The unexplained survival of cells in oral cancer: what is the role of p53?. J Oral Pathol Med 31 3 (2002 Mar) 125-133
52. Hollenbeck P.J. The pattern and mechanism of mitochondrial transport in axons. Front Biosci 1 (1996 Jul 1) d91-102
53. Nicotine W.L. CO and HCN: the detrimental effects of smoking on wound healing. Br J Community Nurs 8 12 (2003 Dec) S22-S26
54. Gaston M.S., and Simpson A.H. Inhibition of fracture healing. J Bone Joint Surg Br 89 12 (2007 Dec) 1553-1560
55. Wright V.J. Osteoporosis in men. J Am Acad Orthop Surg 14 6 (2006 Jun) 347-353
56. Baron J.A. Smoking and estrogen-related disease. Am J Epidemiol 119 1 (1984 Jan) 9-22
57. Lam L.T. Distractions and the risk of car crash injury: the effect of drivers' age. J Safety Res 33 3 (2002 Fall) 411-419
58. Wen C.P., Tsai S.P., Cheng T.Y., Chan H.T., Chung W.S., and Chen C.J. Excess injury mortality among smokers: a neglected tobacco hazard. Tob Control 14 Suppl. 1 (2005 Jun) i28-i32
59. Nelson H.D., Nevitt M.C., Scott J.C., Stone K.L., and Cummings S.R. Smoking, alcohol, and neuromuscular and physical function of older women. Study of Osteoporotic Fractures Research Group. JAMA 272 23 (1994 Dec 21) 1825-1831
60. Sacks J.J., and Nelson D.E. Smoking and injuries: an overview. Prev Med 23 4 (1994 Jul) 515-520
61. Kyro A., Usenius J.P., Aarnio M., Kunnamo I., and Avikainen V. Are smokers a risk group for delayed healing of tibial shaft fractures?. Ann Chir Gynaecol 82 4 (1993) 254-262
62. Brown C.W., Orme T.J., and Richardson H.D. The rate of pseudarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study. Spine 11 9 (1986 Nov) 942-943
63. Silcox III D.H., Daftari T., Boden S.D., Schimandle J.H., Hutton W.C., and Whitesides Jr. T.E. The effect of nicotine on spinal fusion. Spine 20 14 (1995 Jul 15) 1549-1553
64. Whitesides Jr. T.E., Hanley Jr. E.N., and Fellrath Jr. R.F. Smoking abstinence. Is it necessary before spinal fusion?. Spine 19 17 (1994 Sep 1) 2012-2014
65. Carpenter C.T., Dietz J.W., Leung K.Y., Hanscom D.A., and Wagner T.A. Repair of a pseudarthrosis of the lumbar spine. A functional outcome study. J Bone Joint Surg Am 78 5 (1996 May) 712-720
66. Adams C.I., Keating J.F., and Court-Brown C.M. Cigarette smoking and open tibial fractures. Injury 32 1 (2001 Jan) 61-65
67. van Adrichem L.N., Hovius S.E., van Strik R., and van der Meulen J.C. The acute effect of cigarette smoking on the microcirculation of a replanted digit. J Hand Surg [Am] 17 2 (1992 Mar) 230-234
68. Gullihorn L., Karpman R., and Lippiello L. Differential effects of nicotine and smoke condensate on bone cell metabolic activity. J Orthop Trauma 19 1 (2005 Jan) 17-22
69. Skott M., Andreassen T.T., Ulrich-Vinther M., Chen X., Keyler D.E., LeSage M.G., et al. Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats. J Orthop Res 24 7 (2006 Jul) 1472-1479
70. Raikin S.M., Landsman J.C., Alexander V.A., Froimson M.I., and Plaxton N.A. Effect of nicotine on the rate and strength of long bone fracture healing. Clin Orthop Relat Res 353 (1998 Aug) 231-237
71. Shapiro F. Bone development and its relation to fracture repair. The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cell Mater 15 (2008) 53-76
72. Campanile G., Hautmann G., and Lotti T. Cigarette smoking, wound healing, and face-lift. Clin Dermatol 16 5 (1998 Sep-Oct) 575-578
73. Abidi N.A., Dhawan S., Gruen G.S., Vogt M.T., and Conti S.F. Wound-healing risk factors after open reduction and internal fixation of calcaneal fractures. Foot Ankle Int 19 12 (1998 Dec) 856-861
74. Lind J., Kramhoft M., and Bodtker S. The influence of smoking on complications after primary amputations of the lower extremity. Clin Orthop Relat Res 267 (1991 Jun) 211-217