Inflammation-induced shift in spinal GABAA signaling is associated with a tyrosine kinase-dependent increase in GABAA current density in nociceptive afferents

Journal of Neurophysiology

Volumn 108, Issue 9, 2012, Pages 2581-2593

  Zhu, Yi ^a,b   Dua, Shiv ^b   Gold, Michael S ^b,c  

^a UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Dorsal root ganglion; Nociceptor; Patch clamp; Persistent pain

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; CALCIUM ION; GENISTEIN; INHIBITOR PROTEIN; MESSENGER RNA; MUSCIMOL; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; GABAERGIC TRANSMISSION; INFLAMMATION; INFLAMMATORY PAIN; MALE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PERIKARYON; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SENSORY NERVE; SIGNAL TRANSDUCTION; SKIN NERVE; SPINAL CORD NERVE CELL; SPINAL GANGLION;

ACTION POTENTIALS; ANIMALS; CALCIUM; FREUND'S ADJUVANT; GABA-A RECEPTOR AGONISTS; GABA-A RECEPTOR ANTAGONISTS; GABAERGIC NEURONS; GANGLIA, SPINAL; GENISTEIN; INFLAMMATION; MALE; MUSCIMOL; NOCICEPTORS; OLIGOPEPTIDES; PROTEIN-TYROSINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SENSORY THRESHOLDS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84868334118     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00590.2012     Document Type: Article

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