Identification of the Functional Domains of the Telomere Protein Rap1 in Schizosaccharomyces pombe

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Fujita, Ikumi ^a   Tanaka, Makiko ^a   Kanoh, Junko ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; PROTEIN BQT1; PROTEIN BQT2; PROTEIN POZL; PROTEIN TAZL; RAP1 PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DELETION MUTANT; GENE SILENCING; MEIOSIS; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SCHIZOSACCHAROMYCES POMBE; TELOMERE; TELOMERE HOMEOSTASIS;

BINDING SITES; CHROMATIN; DNA; G1 PHASE; GENE SILENCING; GENETIC VARIATION; MEIOSIS; MUTATION; PROTEIN STRUCTURE, TERTIARY; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TELOMERE; TELOMERE-BINDING PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

EID: 84868329026     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049151     Document Type: Article

References (40)

1. Meyne J, Ratliff RL, Moyzis RK, (1989) Conservation of the human telomere sequence (TTAGGG)n among vertebrates. Proc Nat Acad Sci USA 86: 7049-7053.
2. Hiraoka Y, Henderson E, Blackburn E, (1998) Not so peculiar: fission yeast telomere repeats. Trends Biochem Sci 23: 126.
3. Kanoh J, Ishikawa F, (2003) Composition and conservation of the telomeric complex. Cell Mol Life Sci 60: 2295-2302.
4. Smogorzewska A, de Lange T, (2004) Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73: 177-208.
5. Ferreira MG, Miller KM, Cooper JP, (2004) Indecent exposure: when telomeres become uncapped. Mol Cell 13: 7-18.
6. Stewart JA, Chaiken MF, Wang F, Price CM, (2012) Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation. Mut Res 730: 12-19.
7. de La Roche Saint-Andre C, (2008) Alternative ends: telomeres and meiosis. Biochimie 90: 181-189.
8. Cooper JP, Nimmo ER, Allshire RC, Cech TR, (1997) Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature 385: 744-747.
9. Cooper JP, Watanabe Y, Nurse P, (1998) Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination. Nature 392: 828-831.
10. Chikashige Y, Hiraoka Y, (2001) Telomere binding of the Rap1 protein is required for meiosis in fission yeast. Curr Biol 11: 1618-1623.
11. Ferreira MG, Cooper JP, (2001) The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions. Mol Cell 7: 55-63.
12. Kanoh J, Ishikawa F, (2001) spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr Biol 11: 1624-1630.
13. Kanoh J, Sadaie M, Urano T, Ishikawa F, (2005) Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres. Curr Biol 15: 1808-1819.
14. Miller KM, Ferreira MG, Cooper JP, (2005) Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres. EMBO J 24: 3128-3135.
15. Chikashige Y, Yamane M, Okamasa K, Tsutsumi C, Kojidani T, et al. (2009) Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation. J Cell Biol 187: 413-427.
16. Bianchi A, Shore D, (2008) How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex. Mol Cell 31: 153-165.
17. Chikashige Y, Tsutsumi C, Yamane M, Okamasa K, Haraguchi T, et al. (2006) Meiotic proteins Bqt1 and Bqt2 tether telomeres to form the bouquet arrangement of chromosomes. Cell 125: 59-69.
18. Miyoshi T, Kanoh J, Saito M, Ishikawa F, (2008) Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length. Science 320: 1341-1344.
19. Chen Y, Rai R, Zhou ZR, Kanoh J, Ribeyre C, et al. (2011) A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol 18: 213-221.
20. Konig P, Giraldo R, Chapman L, Rhodes D, (1996) The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA. Cell 85: 125-136.
21. Hardy CF, Sussel L, Shore D, (1992) A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6: 801-814.
22. Moretti P, Freeman K, Coodly L, Shore D, (1994) Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev 8: 2257-2269.
23. Cockell M, Palladino F, Laroche T, Kyrion G, Liu C, et al. (1995) The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J Cell Biol 129: 909-924.
24. Wotton D, Shore D, (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11: 748-760.
25. Fujita I, Nishihara Y, Tanaka M, Tsujii H, Chikashige Y, et al. (2012) Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation. Curr Biol. Available: http://dx.doi.org/10.1016/j.cub.2012.1008.1019.
26. Hansen KR, Ibarra PT, Thon G, (2006) Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. Nucleic Acids Res 34: 78-88.
27. Kyrion G, Boakye KA, Lustig AJ, (1992) C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell Biol 12: 5159-5173.
28. Kyrion G, Liu K, Liu C, Lustig AJ, (1993) RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev 7: 1146-1159.
29. Martinez P, Thanasoula M, Carlos AR, Gomez-Lopez G, Tejera AM, et al. (2010) Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol 12: 768-780.
30. Dehe PM, Rog O, Ferreira MG, Greenwood J, Cooper JP, (2012) Taz1 enforces cell-cycle regulation of telomere synthesis. Mol Cell 46: 797-808.
31. Chikashige Y, Haraguchi T, Hiraoka Y, (2007) Another way to move chromosomes. Chromosoma 116: 497-505.
32. Scherthan H, Sfeir A, de Lange T, (2011) Rap1-independent telomere attachment and bouquet formation in mammalian meiosis. Chromosoma 120: 151-157.
33. Miller KM, Cooper JP, (2003) The telomere protein Taz1 is required to prevent and repair genomic DNA breaks. Mol Cell 11: 303-313.
34. Tazumi A, Fukuura M, Nakato R, Kishimoto A, Takenaka T, et al. (2012) Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast. Genes & development 26: 2050-2062.
35. Li B, de Lange T, (2003) Rap1 affects the length and heterogeneity of human telomeres. Mol Biol Cell 14: 5060-5068.
36. Leung CC, Glover JN, (2011) BRCT domains: easy as one, two, three. Cell Cycle 10: 2461-2470.
37. Moreno S, Klar A, Nurse P, (1991) Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol 194: 795-823.
38. Forsburg SL, Rhind N, (2006) Basic methods for fission yeast. Yeast 23: 173-183.
39. Bahler J, Wu JQ, Longtine MS, Shah NG, McKenzie A 3rd, et al (1998) Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast 14: 943-951.
40. Matsuura A, Naito T, Ishikawa F, (1999) Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3+ and tel1+ are parts of two regulatory networks independent of the downstream protein kinases chk1+ and cds1+. Genetics 152: 1501-1512.