In vivo corrosion, tumor outcome, and microarray gene expression for two types of muscle-implanted tungsten alloys

Toxicology and Applied Pharmacology

Volumn 265, Issue 1, 2012, Pages 128-138

  Schuster, B E ^a   Roszell, L E ^b   Murr, L E ^c   Ramirez, D A ^c   Demaree, J D ^a   Klotz, B R ^d   Rosencrance, A B ^e   Dennis, W E ^e   Bao, W ^f   Perkins, E J ^g   Dillman, J F ^h   Bannon, D I ^b  

^a U S ARMY RESEARCH LABORATORY   (United States)

^b US Army Institute of Public Health   (United States)

^c 500 W University Avenue   (United States)

^d Dynamic Science Inc   (United States)

^e US Army Center for Environmental Health Research Ft Detrick   (United States)

^f SAS INSTITUTE INC   (United States)

^g US ARMY ENGINEER RESEARCH AND DEVELOPMENT CENTER   (United States)

^h US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Cobalt; MDM2; Microarray; Nickel; Rhabdomyosarcoma; Tungsten alloy

Indexed keywords

ALLOY; COBALT; CYCLIN DEPENDENT KINASE 4; IRON; NICKEL; PROTEIN MDM2; TANTALUM; TUNGSTEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CHROMOSOME 7P; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CORROSION; ELECTRON MICROSCOPY; GENE EXPRESSION; IN VIVO STUDY; MALE; MICROARRAY ANALYSIS; MUSCLE; NONHUMAN; RAT; RHABDOMYOSARCOMA; URINALYSIS;

ALLOYS; ANIMALS; CARCINOGENS; COBALT; CYCLIN-DEPENDENT KINASE 4; DRUG IMPLANTS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDICATORS AND REAGENTS; INJECTIONS, INTRAMUSCULAR; MALE; METALS; MICE; MICROARRAY ANALYSIS; MUSCLE NEOPLASMS; NEOPLASMS, EXPERIMENTAL; NICKEL; PROTO-ONCOGENE PROTEINS C-MDM2; RATS; RATS, INBRED F344; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; TUNGSTEN;

ANIMALIA; RATTUS;

EID: 84868304188     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.08.025     Document Type: Article

References (49)

1. Agency for Toxic Substances, Disease Registry (ATSDR) Toxicological Profile for Nickel 2005, US Department of Health and Human Services, Public Health Service, Atlanta, GA.
2. Arita A., Costa M. Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium. Metallomics 2009, 1:222-228.
3. Arrouijal F.Z., Hildebrand H.F., Vophi H., Marzin D. Genotoxic activity of nickel subsulphide alpha-Ni3S2. Mutagenesis 1990, 5:583-589.
4. Bannon D.I., Drexler J.W., Fent G.M., Casteel S.W., Hunter P.J., Brattin W.J., Major M.A. Evaluation of small arms range soils for metal contamination and lead bioavailability. Environ. Sci. Technol. 2009, 43:9071-9076.
5. Chen H., Giri N.C., Zhang R., Yamane K., Zhang Y., Maroney M., Costa M. Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. J. Biol. Chem. 2010, 285:7374-7383.
6. Costa M., Salnikow K., Cosentino S., Klein C.B., Huang X., Zhuang Z. Molecular mechanisms of nickel carcinogenesis. Environ. Health Perspect. 1994, 102(3):127-130.
7. Damjanov I., Sunderman F.W., Mitchell J.M., Allpass P.R. Induction of testicular sarcomas in Fischer rats by intratesticular injection of nickel subsulfide. Cancer Res. 1978, 38:268-276.
8. Davidson T.L., Chen H., Di Toro D.M., D'Angelo G., Costa M. Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol. Carcinog. 2006, 45:479-489.
9. Dillman J.F., Phillips C.S., Kniffin D.M., Tompkins C.P., Hamilton T.A., Kan R.K. Gene expression profiling of rat hippocampus following exposure to the acetylcholinesterase inhibitor soman. Chem. Res. Toxicol. 2009, 22:633-638.
10. German R.M. Sintering Theory and Practice 1996, Wiley, New York.
11. Goodman J.E., Prueitt R.L., Thakali S., Oller A.R. The nickel ion bioavailability model of the carcinogenic potential of nickel-containing substances in the lung. Crit. Rev. Toxicol. 2010, 41:142-174.
12. Grimsrud T.K., Berge S.R., Haldorsen T., Andersen A. Exposure to different forms of nickel and risk of lung cancer. Am. J. Epidemiol. 2002, 156:1123-1132.
13. Harris R.M., Williams T.D., Hodges N.J., Waring R.H. Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloys in vitro. Toxicol. Appl. Pharmacol. 2011, 250:19-28.
14. Heath J.C. The histogenesis of malignant tumours induced by cobalt in the rat. Br. J. Cancer 1960, 14:478-482.
15. Hodgson J.G., Yeh R.F., Ray A., Wang N.J., Smirnov I., Yu M., Hariono S., Silber J., Feiler H.S., Gray J.W., Spellman P.T., Vandenberg S.R., Berger M.S., James C.D. Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts. Neuro Oncol. 2009, 11:477-487.
16. Hoots E.A., Renberg W.C., Patton K.M., Roush J.K. Evaluation of local and systemic effects after intramuscular implantation of lead shot alternatives in rats. Am. J. Vet. Res. 2007, 68:446-452.
17. Huang D., Sherman B.T., Lempciki R.A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009, 37:1-13.
18. Huang D., Sherman B.T., Lempciki R.A. Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nat. Protoc. 2009, 4:44-57.
19. Hunt C.R., Sim J.E., Sullivan S.J., Featherstone T., Golden W., Von Kapp-Herr C., Hock R.A., Gomez R.A., Parsian A.J., Spitz D.R. Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Res. 1998, 58:3986-3992.
20. Italiano A., Cardot N., Dupre F., Monticelli I., Keslair F., Piche M., Mainguene C., Coindre J.M., Pedeutour F. Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the "missing link" between lipomas and liposarcomas?. Int. J. Cancer 2007, 121:308-315.
21. Kalinich J.F., Emond C.A., Dalton T.K., Mog S.R., Coleman G.D., Kordell J.E., Miller A.C., McClain D.E. Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats. Environ. Health Perspect. 2005, 113:729-734.
22. Kappler R., Bauer R., Calzada-Wack J., Rosemann M., Hemmerlein B., Hahn H. Profiling the molecular difference between patched- and p53-dependent rhabdomyosarcoma. Oncogene 2004, 23:8785-8795.
23. Kawanishi S., Inoue S., Oikawa S., Yamashita N., Toyokuni S., Kawanishi M., Nishino K. Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds. Free Radic. Biol. Med. 2001, 31:108-116.
24. Kimura Y., Nakazawa M., Yamada M. Cloning and characterization of three isoforms of OS-9 cDNA and expression of the OS-9 gene in various human tumor cell lines. J. Biochem. 1998, 123:876-882.
25. Krueger I., Mullenders L.H., Hartwig A. Nickel(II) increases the sensitivity of V79 Chinese hamster cells towards cisplatin and transplatin by interference with distinct steps of DNA repair. Carcinogenesis 1999, 20:1177-1184.
26. Ladanyi M., Lewis R., Jhanwar S.C., Gerald W., Huvos A.G., Healey J.H. MDM2 and CDK4 gene amplification in Ewing's sarcoma. J. Pathol. 1995, 175:211-217.
27. Lassner E., Schubert W.D. Tungsten: Properties, Chemistry, Technology of the Element, Alloays, and Chemical Compounds 1999, Kluwer Academic/Plenum Publishers, New York.
28. Leach F.S., Tokino T., Meltzer P., Burrell M., Oliner J.D., Smith S., Hill D.E., Sidransky D., Kinzler K.W., Vogelstein B. p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 1993, 53:2231-2234.
29. Limoli C.L., Giedzinski E. Induction of chromosomal instability by chronic oxidative stress. Neoplasia 2003, 5:339-346.
30. Lopes M.A., Nikitakis N.G., Ord R.A., Sauk J. Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws. Oral Oncol. 2001, 37:566-571.
31. Lu H., Shi X., Costa M., Huang C. Carcinogenic effect of nickel compounds. Mol. Cell. Biochem. 2005, 279:45-67.
32. Lumb G., Sunderman F.W. The mechanism of malignant tumor induction by nickel subsulfide. Annals Clin. Lab. Sci. 1988, 18:353-366.
33. Malmlof M., Paajarvi G., Hogberg J., Stenius U. Mdm2 as a sensitive and mechanistically informative marker for genotoxicity induced by benzo[a]pyrene and dibenzo[a]pyrene. Toxicol. Sci. 2008, 102:232-240.
34. Mejia-Guerrero S., Quejada M., Gokgoz N., Gill M., Parkes R.K., Wunder J.S., Andrulis I.L. Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Genes Chromosom. Cancer 2010, 49:518-525.
35. Miller A.C., Mog S., McKinney L., Luo L., Allen J., Xu J., Page N. Neoplastic transformation of human osteoblast cells to the tumorigenic phenotype by heavy metal-tungsten alloy particles: induction of genotoxic effects. Carcinogenesis 2001, 22:115-125.
36. Miller A.C., Brooks K., Smith J., Page N. Effect of the militarily-relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2). Mol. Cell. Biochem. 2004, 255:247-256.
37. Muthusamy V., Hobbs C., Nogueira C., Cordon-Cardo C., McKee P.H., Chin L., Bosenberg M.W. Amplification of CDK4 and MDM2 in malignant melanoma. Genes Chromosom Cancer 2006, 45:447-454.
38. Ogundipe A., Greenberg B., Braida W., Christodoulatos C., Dermatas D. Morphological characterisation and spectroscopic studies of the corrosion behaviour of tungsten heavy alloys. Corros Sci 2006, 48:3281-3297.
39. Oliner J.D., Kinzler K.W., Meltzer P.S., George D.L., Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992, 358:80-83.
40. Roch-Lefevre S., Daino K., Altmeyer-Morel S., Guilly M.N., Chevillard S. Cytogenetic and molecular characterization of plutonium-induced rat osteosarcomas. J. Radiat. Res. (Tokyo) 2010, 51:243-250.
41. Roszell L. Toxicological and Carcinogenic Potential of Tungsten and Tungsten/Nickel/Iron Alloy Implanted in the Leg Muscle of Rischer-344 Rats. Army Institute of Public Health Technical Report 2011, Volumes I-1V.
42. Seoane A.I., Dulout F.N. Genotoxic ability of cadmium, chromium and nickel salts studied by kinetochore staining in the cytokinesis-blocked micronucleus assay. Mutat Res 2001, 490:99-106.
43. Somers G.R., Ho M., Pienkowska M., Shlien A., Malkin D., Ackerley C., Zielenska M. IGF2 is highly expressed in pediatric undifferentiated sarcomas and reveals two distinct cytoplasmic trafficking patterns. Pediatr. Dev. Pathol. 2010, 13:169-177.
44. Syrett B.C., Acharya A. Corrosion and Degradation of Implant Materials 1979, ASTM.
45. Vander Voort G.F. Metallography: Principles and Practices 1999, ASM International.
46. Vander Voort G.F. ASM Handbook. Metallography and Microstructures 2004, vol. 9. ASM, Materials Park, Ohio, 44073-0002.
47. Verma R., Xu X., Jaiswal M.K., Olsen C., Mears D., Caretti G., Galdzicki Z. In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components. Toxicol. Appl. Pharmacol. 2011, 253:178-187.
48. Williams L.R., Cheng J. Cao, Lent E.M., Crouse L.C.B., Bazar M.A., Johnson M.S. Toxicologic charactarization of a novel explosve, triaminoguanidinium-1-methyl-5-nitrominotetrazolate (TAG-MNT), in female rats and in vitro assays. J Toxicol Environ Health Sci 2011, 3:80-94.
49. Young J.J.J. Memorandum for Chariman of Joint Chiefs of Staff 2007, US Department of Defense.